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Correction: Corrigendum: RNA m⁶A methylation regulates the ultraviolet-induced DNA damage response

Yang Xiang
Benoit Laurent
Yang Shi
Amendments and Corrections29 Nov 2017
Nature

Volume: 552, P: 430
Publisher Correction: Recognition of RNA N⁶-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huilin Huang
Hengyou Weng
Jianjun Chen
Amendments and Corrections27 Aug 2020
Nature Cell Biology

Volume: 22, P: 1288
Author Correction: Recognition of RNA N⁶-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huilin Huang
Hengyou Weng
Jianjun Chen
Amendments and Corrections07 Jun 2018
Nature Cell Biology

Volume: 20, P: 1098
The dynamic N¹-methyladenosine methylome in eukaryotic messenger RNA

Here the m¹A modification is discovered in messenger RNA and mapped at the transcriptome-wide level; the modification is conserved, dynamic, accumulates in structured regions around translation initiation sites upstream of the first splice site, and correlates with higher protein expression.

Dan Dominissini
Sigrid Nachtergaele
Chuan He
Research10 Feb 2016
Nature

Volume: 530, P: 441-446
Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation

TET mediated RNA-hydroxymethylation (5hmC) has been detected in mammals, but its physiological role remains unclear. Here the authors map 5hmC during embryonic stem cell (ESC) differentiation and find that Tet-mediated RNA hydroxymethylation reduces the stability of crucial pluripotency related transcripts.

Jie Lan
Nicholas Rajan
François Fuks
ResearchOpen Access02 Oct 2020
Nature Communications

Volume: 11, P: 1-15
Oxysterols are allosteric activators of the oncoprotein Smoothened

20(S)-hydroxycholesterol binds to Smo at a site distinct from cyclopamine and activates signaling via an allosteric mechanism. A new alkyne oxysterol analog selectively captures Smo from membrane extracts and provides a new method for detecting protein-sterol interactions.

Sigrid Nachtergaele
Laurel K Mydock
Rajat Rohatgi
Research08 Jan 2012
Nature Chemical Biology

Volume: 8, P: 211-220
Evolution of a reverse transcriptase to map N¹-methyladenosine in human messenger RNA

Robust m¹A mapping of the human transcriptome is enabled by directed evolution of an HIV-1 reverse transcriptase with efficient read-through and high mutation rates at m¹A sites along with development of new tools for data analysis.

Huiqing Zhou
Simone Rauch
Bryan C. Dickinson
Research23 Sept 2019
Nature Methods

Volume: 16, P: 1281-1288
Structural basis of Smoothened regulation by its extracellular domains

Structural studies show that the activity of the G-protein-coupled receptor Smoothened is modulated by ligand-regulated interactions between its extracellular and transmembrane domains.

Eamon F. X. Byrne
Ria Sircar
Christian Siebold
Research20 Jul 2016
Nature

Volume: 535, P: 517-522
Recognition of RNA N⁶-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huang et al. identify IGF2BPs as an additional class of N⁶-methyladenosine (m⁶A) reader proteins. They find that IGF2BPs selectively bind to m⁶A-containing mRNAs and promote their stability.

Huilin Huang
Hengyou Weng
Jianjun Chen
Research23 Feb 2018
Nature Cell Biology

Volume: 20, P: 285-295
RNA m⁶A methylation regulates the ultraviolet-induced DNA damage response

Methylation at the 6 position of adenosine (m⁶A) in RNA is rapidly and transiently induced at DNA damage sites in response to ultraviolet irradiation.

Yang Xiang
Benoit Laurent
Yang Shi
Research15 Mar 2017
Nature

Volume: 543, P: 573-576

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