Nature Search

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries

Genome-wide association analyses of intracranial and nine subcortical brain volumes in 74,898 participants of European ancestry identify 254 independent loci and yield polygenic scores accounting for brain variation across ancestries.

Luis M. García-Marín
Adrian I. Campos
Miguel E. Rentería
Research21 Oct 2024
Nature Genetics

Volume: 56, P: 2333-2344
Novel genetic loci underlying human intracranial volume identified through genome-wide association

In a GWAS study of 32,438 adults, the authors discovered five novel loci for intracranial volume and confirmed two known signals. Variants for intracranial volume were also related to childhood and adult cognitive function and to Parkinson's disease, and enriched near genes involved in growth pathways, including PI3K-AKT signaling.

Hieab H H Adams
Derrek P Hibar
Paul M Thompson
Research03 Oct 2016
Nature Neuroscience

Volume: 19, P: 1569-1582
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Cognitive function is associated with health and important life outcomes. Here, the authors perform a genome-wide association study for general cognitive function in 300,486 individuals and identify genetic loci that implicate neural and cell developmental pathways in this trait.

Gail Davies
Max Lam
Ian J. Deary
ResearchOpen Access29 May 2018
Nature Communications

Volume: 9, P: 1-16
Genetic architecture of subcortical brain structures in 38,851 individuals

Genome-wide analysis identifies variants associated with the volume of seven different subcortical brain regions defined by magnetic resonance imaging. Implicated genes are involved in neurodevelopmental and synaptic signaling pathways.

Claudia L. Satizabal
Hieab H. H. Adams
M. Arfan Ikram
Research21 Oct 2019
Nature Genetics

Volume: 51, P: 1624-1636
Novel genetic loci associated with hippocampal volume

The hippocampus in mammalian brain varies in size across individuals. Here, Hibar and colleagues perform a genome-wide association meta-analysis to find six genetic loci with significant association to hippocampus volume.

Derrek P. Hibar
Hieab H. H. Adams
M. Arfan Ikram
ResearchOpen Access18 Jan 2017
Nature Communications

Volume: 8, P: 1-12
Suicide and self-harm in older adults

Older adults have the highest suicide rates of any age group, but the mechanisms leading to this behaviour remain understudied. In this Review, Connors et al. integrate epidemiological research with psychological theories and interventions to better understand and prevent suicide and self-harm in older adults.

Michael H. Connors
Brian Draper
Simone Reppermund
Reviews20 May 2025
Nature Reviews Psychology

Volume: 4, P: 440-456
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

Barbara Franke
Jason L Stein
Patrick F Sullivan
Research01 Feb 2016
Nature Neuroscience

Volume: 19, P: 420-431
Longitudinal associations between fruit and vegetable intakes and depressive symptoms in middle-aged and older adults from four international twin cohorts

Annabel P. Matison
Anbupalam Thalamuthu
Karen A. Mather
ResearchOpen Access29 Nov 2024
Scientific Reports

Volume: 14, P: 1-10
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.

Edith Hofer
Gennady V. Roshchupkin
Sudha Seshadri
ResearchOpen Access22 Sept 2020
Nature Communications

Volume: 11, P: 1-16
Updating risk and protective factors for dementia in older adults

Researchers have identified several environmental and personal characteristics that might accelerate cognitive decline in older adults but that are not yet listed as established risk factors for dementia. In this Review, Rodriguez et. al. explore the potential of these less well-established factors to prevent dementia and foster healthy cognitive ageing.

Francisca S. Rodriguez
Lena M. Hofbauer
Susanne Röhr
Reviews28 Mar 2025
Nature Reviews Psychology

Volume: 4, P: 322-335
Common genetic variants influence human subcortical brain structures

Genome-wide association studies are used to identify common genetic variants that affect the structure of selected subcortical regions of the human brain; their identification provides insight into the causes of variability in brain development and may help to determine mechanisms of neuropsychiatric dysfunction.

Derrek P. Hibar
Jason L. Stein
Sarah E. Medland
Research21 Jan 2015
Nature

Volume: 520, P: 224-229
Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Gail Davies
Max Lam
Ian J. Deary
Amendments and CorrectionsOpen Access01 May 2019
Nature Communications

Volume: 10, P: 1-5
Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Jari Lahti
Samuli Tuominen
Katri Räikkönen
ResearchOpen Access16 Aug 2022
Molecular Psychiatry

Volume: 27, P: 4419-4431
Genome-wide significant results identified for plasma apolipoprotein H levels in middle-aged and older adults

Karen A. Mather
Anbupalam Thalamuthu
Perminder S. Sachdev
ResearchOpen Access31 Mar 2016
Scientific Reports

Volume: 6, P: 1-9

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