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Showing 1–4 of 4 results
Advanced filters: Author: Sohyon Lee Clear advanced filters

  • A single-cell ex vivo screening of repurposable drugs in glioblastoma and machine learning of drug–target networks show that anti-tumor neuroactive drugs converge on the AP-1/BTG pathway, based on which prediction models and experimental in vivo and in silico validation identify the anti-depressant vortioxetine as a potential therapeutic agent.

    • Sohyon Lee
    • Tobias Weiss
    • Berend Snijder
    ResearchOpen Access
    Nature Medicine
    Volume: 30, P: 3196-3208

  • A screen in which combinatorial pairs of transcription factors are exogenously expressed in fibroblasts identifies different combinations that reprogram these cells into induced neuronal cells with diverse functional properties.

    • Rachel Tsunemoto
    • Sohyon Lee
    • Kristin K. Baldwin
    Research
    Nature
    Volume: 557, P: 375-380

  • Personalized treatment for cancer patients relies on the deep characterization of tumor cells from patient biopsies. In this study, functional multi-omics profiling of a pan-cancer cohort of malignant serous effusions (MSE) finds strong coherence between MSE and matched solid tumors, underlining the feasibility and utility of multi-modal MSE-based precision oncology.

    • Rebekka Wegmann
    • Lorenz Bankel
    • Berend Snijder
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21