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Protein-responsive gut hormone tachykinin directs food choice and impacts lifespan

The gut hormone tachykinin (Tk) is found to be regulated by protein intake in flies and mice. In flies, Tk is shown to impact food choices, sleep and lifespan.

Nadja Ahrentløv
Olga Kubrak
Kim Rewitz
ResearchOpen Access14 Apr 2025
Nature Metabolism

Volume: 7, P: 1223-1245
LGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin resistance

Obesity induces insulin resistance and impairs insulin signaling, causing diabetes. Here, the authors show that BMP and LGR signaling mediate communication between muscle, neuronal, and adipose tissues to enhance insulin signaling, identifying LGR as key in protecting against insulin resistance.

Olga Kubrak
Anne F. Jørgensen
Kim Rewitz
ResearchOpen Access20 Jul 2024
Nature Communications

Volume: 15, P: 1-22
The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress

Intestinal nutrient-sensing is important in metabolic control. Here the authors show that the gut-derived hormone Allatostatin C, a somatostatin homolog in fruit flies, links enteric nutrient sensing to behavioral and metabolic adaptations that maintain energetic homeostasis in Drosophila melanogaster.

Olga Kubrak
Takashi Koyama
Kim Rewitz
ResearchOpen Access04 Feb 2022
Nature Communications

Volume: 13, P: 1-17
A gut-derived hormone suppresses sugar appetite and regulates food choice in Drosophila

Malita, Kubrak et al. show that the gut-derived hormone neuropeptide F suppresses sugar intake and increases the consumption of protein-rich food in Drosophila. This gives insight into the regulation of nutrient-specific appetite that ensures appropriate food choices to meet nutritional demands.

Alina Malita
Olga Kubrak
Kim Rewitz
ResearchOpen Access07 Nov 2022
Nature Metabolism

Volume: 4, P: 1532-1550
A nutrient-responsive hormonal circuit mediates an inter-tissue program regulating metabolic homeostasis in adult Drosophila

Maintaining metabolic homeostasis during feeding and fasting states is critical to animal survival. Here the authors show that Capa hormone signaling, homologs to mammalian Neuromedin U, helps control homeostasis via regulation of nutrient uptake and energy storage in Drosophila.

Takashi Koyama
Selim Terhzaz
Kenneth V. Halberg
ResearchOpen Access30 Aug 2021
Nature Communications

Volume: 12, P: 1-19
The genomic history of southeastern Europe

Genome-wide ancient DNA data from 225 individuals who lived in southeastern Europe between 12000 and 500 bc reveals that the region acted as a genetic crossroads before and after the arrival of farming.

Iain Mathieson
Songül Alpaslan-Roodenberg
David Reich
Research21 Feb 2018
Nature

Volume: 555, P: 197-203
Long-term carbon sink in Borneo’s forests halted by drought and vulnerable to edge effects

The existence of a pan-tropical forest carbon sink remains uncertain due to the lack of data from Asia. Here, using direct on-the-ground observations, the authors confirm remaining intact forests in Borneo have provided a long-term carbon sink, but carbon net gains are vulnerable to drought and edge effects.

Lan Qie
Simon L. Lewis
Oliver L. Phillips
ResearchOpen Access19 Dec 2017
Nature Communications

Volume: 8, P: 1-11
Author Correction: Long-term carbon sink in Borneo’s forests halted by drought and vulnerable to edge effects

Lan Qie
Simon L. Lewis
Oliver L. Phillips
Amendments and CorrectionsOpen Access19 Jan 2018
Nature Communications

Volume: 9, P: 1-2
Large range sizes link fast life histories with high species richness across wet tropical tree floras

Timothy R. Baker
Stephen Adu-Bredu
Lise Zemagho
ResearchOpen Access08 Feb 2025
Scientific Reports

Volume: 15, P: 1-15
Caenorhabditis elegans exhibit a coupling between the defecation motor program and directed locomotion

Stanislav Nagy
Yung-Chi Huang
David Biron
ResearchOpen Access24 Nov 2015
Scientific Reports

Volume: 5, P: 1-13

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Protein-responsive gut hormone tachykinin directs food choice and impacts lifespan

LGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin resistance

The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress

A gut-derived hormone suppresses sugar appetite and regulates food choice in Drosophila

A nutrient-responsive hormonal circuit mediates an inter-tissue program regulating metabolic homeostasis in adult Drosophila

The genomic history of southeastern Europe

Long-term carbon sink in Borneo’s forests halted by drought and vulnerable to edge effects

Author Correction: Long-term carbon sink in Borneo’s forests halted by drought and vulnerable to edge effects

Large range sizes link fast life histories with high species richness across wet tropical tree floras

Caenorhabditis elegans exhibit a coupling between the defecation motor program and directed locomotion

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