Nature Search

Cognitive reserve against Alzheimer’s pathology is linked to brain activity during memory formation

Here, the authors identify a cognitive reserve-related activity pattern underlying successful memory encoding. They further derive individual reserve scores that predict the maintenance of cognitive performance in the face of Alzheimer’s disease pathology.

Niklas Vockert
Judith Machts
Gabriel Ziegler
ResearchOpen Access13 Nov 2024
Nature Communications

Volume: 15, P: 1-16
Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS

Plasma extracellular vesicles contain quantifiable amounts of TDP-43 and full-length tau, allowing the accurate assessment of pathology in frontotemporal dementia, frontotemporal dementia spectrum disorders and amyotrophic lateral sclerosis.

Madhurima Chatterjee
Selcuk Özdemir
Anja Schneider
ResearchOpen Access18 Jun 2024
Nature Medicine

Volume: 30, P: 1771-1783
The role of cognitive and brain reserve in the clinical presentation and progression of amyotrophic lateral sclerosis

Anna G. M. Temp
Gaël Nils Tarakdjian
Andreas Hermann
ResearchOpen Access20 Jun 2025
Scientific Reports

Volume: 15, P: 1-10
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives

Advances in therapeutic strategies for Alzheimer's disease depend on the identification and qualification of biomarkers. Here, the authors review the current status of candidate biomarkers for Alzheimer's disease and provide the perspectives of different stakeholders on biomarker discovery and development.

Harald Hampel
Richard Frank
Kaj Blennow
Reviews01 Jul 2010
Nature Reviews Drug Discovery

Volume: 9, P: 560-574
Tau plasma levels in subjective cognitive decline: Results from the DELCODE study

Stephan Müller
Oliver Preische
Christoph Laske
ResearchOpen Access25 Aug 2017
Scientific Reports

Volume: 7, P: 1-6
Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease

David Mengel
Ester Soter
Matthis Synofzik
ResearchOpen Access18 Apr 2025
Molecular Psychiatry

Volume: 30, P: 3150-3159
Unveiling the power of high-dimensional cytometry data with cyCONDOR

High-dimensional cytometry is a powerful technology for studying single-cell phenotypes in complex biological systems. Here, the authors develop cyCONDOR, a computational framework for high-dimensional cytometry data analysis, covering a comprehensive suite of features in an easy-to-use format.

Charlotte Kröger
Sophie Müller
Lorenzo Bonaguro
ResearchOpen Access19 Dec 2024
Nature Communications

Volume: 15, P: 1-16
Application of IVDr NMR spectroscopy to stratify Parkinson’s disease with absolute quantitation of blood serum metabolites and lipoproteins

Georgy Berezhnoy
Gyuntae Bae
Christoph Trautwein
ResearchOpen Access22 May 2025
Scientific Reports

Volume: 15, P: 1-20
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.

Itziar de Rojas
Sonia Moreno-Grau
Agustín Ruiz
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-16
Practicality of a patient self-assessment checklist to manage dementia risk factors in GP practices

Francisca S. Rodriguez
Hanna L. Knecht
Marina Boccardi
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-10
Basal forebrain volume and metabolism in carriers of the Colombian mutation for autosomal dominant Alzheimer’s disease

Stefan Teipel
Alice Grazia
Nunzio Pomara
ResearchOpen Access17 May 2024
Scientific Reports

Volume: 14, P: 1-11
MiRNA-15b and miRNA-125b are associated with regional Aβ-PET and FDG-PET uptake in cognitively normal individuals with subjective memory complaints

Andrea Vergallo
Simone Lista
José L. Zugaza
ResearchOpen Access27 Jan 2021
Translational Psychiatry

Volume: 11, P: 1-11
Different inflammatory signatures based on CSF biomarkers relate to preserved or diminished brain structure and cognition

Dayana Hayek
Gabriel Ziegler
Anne Maass
ResearchOpen Access12 Jan 2024
Molecular Psychiatry

Volume: 29, P: 992-1004
Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects

Bloemeke et al. develop a method for measuring Aβ oligomers in plasma to diagnose Alzheimer’s Disease. Correlation analysis between cerebral spinal fluid and plasma oligomer concentrations indicates an impaired clearance of Aβ oligomers that is dependent on ApoE ε4 status.

Lara Blömeke
Fabian Rehn
Dieter Willbold
ResearchOpen Access10 Dec 2024
Communications Medicine

Volume: 4, P: 1-13
Designing the next-generation clinical care pathway for Alzheimer’s disease

This Perspective describes the blueprint, challenges and potential solutions for the transformation of Alzheimer’s disease clinical care pathway with biomarker-guided and digitally facilitated detection and intervention at early disease stages.

Harald Hampel
Rhoda Au
Jeffrey Cummings
Reviews19 Aug 2022
Nature Aging

Volume: 2, P: 692-703
Reduced basal forebrain atrophy progression in a randomized Donepezil trial in prodromal Alzheimer’s disease

Enrica Cavedo
Michel J. Grothe
Marie Sarazin
ResearchOpen Access15 Sept 2017
Scientific Reports

Volume: 7, P: 1-10
Associations of cholinergic system integrity with cognitive decline in GBA1 and LRRK2 mutation carriers

Julia Schumacher
Nicola Ray
Alexander Storch
ResearchOpen Access29 Jun 2024
npj Parkinson's Disease

Volume: 10, P: 1-13
A remote digital memory composite to detect cognitive impairment in memory clinic samples in unsupervised settings using mobile devices

David Berron
Wenzel Glanz
Emrah Düzel
ResearchOpen Access26 Mar 2024
npj Digital Medicine

Volume: 7, P: 1-10
Daratumumab after allogeneic hematopoietic cell transplantation for multiple myeloma is safe and synergies with pre-existing chronic graft versus host disease. A retrospective study from the CMWP EBMT

Laure Vincent
Luuk Gras
Meral Beksac
Correspondence10 Jan 2022
Bone Marrow Transplantation

Volume: 57, P: 499-501
Whole-body metabolic modelling reveals microbiome and genomic interactions on reduced urine formate levels in Alzheimer’s disease

Filippo Martinelli
Almut Heinken
Ines Thiele
ResearchOpen Access13 Mar 2024
Scientific Reports

Volume: 14, P: 1-14
Author Correction: Whole-body metabolic modelling reveals microbiome and genomic interactions on reduced urine formate levels in Alzheimer’s disease

Filippo Martinelli
Almut Heinken
Ines Thiele
Amendments and CorrectionsOpen Access12 Nov 2024
Scientific Reports

Volume: 14, P: 1
FDG-PET underscores the key role of the thalamus in frontotemporal lobar degeneration caused by C9ORF72 mutations

Janine Diehl-Schmid
Abigail Licata
Timo Grimmer
ResearchOpen Access31 Jan 2019
Translational Psychiatry

Volume: 9, P: 1-11
The BDNF_Val66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer’s disease

Nicolai Franzmeier
Jinyi Ren
Michael Ewers
Research21 Mar 2019
Molecular Psychiatry

Volume: 26, P: 614-628
Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Itziar de Rojas
Sonia Moreno-Grau
Agustín Ruiz
Amendments and CorrectionsOpen Access09 Feb 2023
Nature Communications

Volume: 14, P: 1-2

Search

Cognitive reserve against Alzheimer’s pathology is linked to brain activity during memory formation

Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS

The role of cognitive and brain reserve in the clinical presentation and progression of amyotrophic lateral sclerosis

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives

Tau plasma levels in subjective cognitive decline: Results from the DELCODE study

Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease

Unveiling the power of high-dimensional cytometry data with cyCONDOR

Application of IVDr NMR spectroscopy to stratify Parkinson’s disease with absolute quantitation of blood serum metabolites and lipoproteins

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Practicality of a patient self-assessment checklist to manage dementia risk factors in GP practices

Basal forebrain volume and metabolism in carriers of the Colombian mutation for autosomal dominant Alzheimer’s disease

MiRNA-15b and miRNA-125b are associated with regional Aβ-PET and FDG-PET uptake in cognitively normal individuals with subjective memory complaints

Different inflammatory signatures based on CSF biomarkers relate to preserved or diminished brain structure and cognition

Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects

Designing the next-generation clinical care pathway for Alzheimer’s disease

Reduced basal forebrain atrophy progression in a randomized Donepezil trial in prodromal Alzheimer’s disease

Associations of cholinergic system integrity with cognitive decline in GBA1 and LRRK2 mutation carriers

A remote digital memory composite to detect cognitive impairment in memory clinic samples in unsupervised settings using mobile devices

Daratumumab after allogeneic hematopoietic cell transplantation for multiple myeloma is safe and synergies with pre-existing chronic graft versus host disease. A retrospective study from the CMWP EBMT

Whole-body metabolic modelling reveals microbiome and genomic interactions on reduced urine formate levels in Alzheimer’s disease

Author Correction: Whole-body metabolic modelling reveals microbiome and genomic interactions on reduced urine formate levels in Alzheimer’s disease

FDG-PET underscores the key role of the thalamus in frontotemporal lobar degeneration caused by C9ORF72 mutations

The BDNF_Val66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer’s disease

Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

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