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Showing 1–3 of 3 results
Advanced filters: Author: Steffen Pabel Clear advanced filters

  • Yamazoe et al. show that B cell-derived autoantibodies contribute to the development of atrial fibrillation, suggesting that targeting the humoral immune response may represent a viable therapeutic approach.

    • Masahiro Yamazoe
    • Kenneth K. Y. Ting
    • Matthias Nahrendorf
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 4, P: 1381-1396

  • Khetarpal et al. show that the metabolic regulator PGC-1α is essential in heart muscle cells for exercise-driven cardiac growth, and that suppression of the stress-induced myokine GDF15 is required to enable cardiomyocyte adaptations to training.

    • Sumeet A. Khetarpal
    • Haobo Li
    • Anthony Rosenzweig
    Research
    Nature Cardiovascular Research
    Volume: 4, P: 1277-1294

  • In heart failure, increased CaMKII activity is decisively involved in arrhythmia formation. Here, the authors introduce the neuronal sodium channel NaV1.8 as a CaMKII downstream target as its specific knock-out reduces arrhythmias and improves survival in a CaMKII-overexpressing mouse model.

    • Philipp Bengel
    • Nataliya Dybkova
    • Samuel Sossalla
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13