Nature Search

The development of aperiodic neural activity in the human brain

This study establishes how aperiodic activity, a ubiquitous signal linked to neural noise, develops in localized brain regions and illuminates the development of prefrontal control during adolescence in the development of attention and memory.

Zachariah R. Cross
Samantha M. Gray
Elizabeth L. Johnson
Research21 Jul 2025
Nature Human Behaviour

P: 1-16
Genomic reanalysis of a pan-European rare-disease resource yields new diagnoses

This flagship study from the European Solve-Rare Diseases Consortium presents a diagnostic framework including bioinformatic analysis of clinical, pedigree and genomic data coupled with expert panel review, leading to 500 new diagnoses in a cohort of 6,000 families with suspected rare diseases.

Steven Laurie
Wouter Steyaert
Alexander Hoischen
ResearchOpen Access17 Jan 2025
Nature Medicine

Volume: 31, P: 478-489
Structures of native SV2A reveal the binding mode for tetanus neurotoxin and anti-epileptic racetams

SV2A, an essential membrane protein in neurotransmission, is known as the receptor of clostridial neurotoxins and target of anti-epileptic drugs. Here the authors show details of the binding site for the drug Levetiracetam and the recognition of Tetanus Neurotoxin.

Stephan Schenck
Toon Laeremans
Janine D. Brunner
ResearchOpen Access05 May 2025
Nature Communications

Volume: 16, P: 1-14
Publisher Correction: Genomic reanalysis of a pan-European rare-disease resource yields new diagnoses

Steven Laurie
Wouter Steyaert
Alexander Hoischen
Amendments and CorrectionsOpen Access19 Jun 2025
Nature Medicine

Volume: 31, P: 2819-2820
Assembly and function of a quaternary signal transduction complex monitored by surface plasmon resonance

Stephan C. Schuster
Ronald V. Swanson
Melvin I. Simon
Research23 Sept 1993
Nature

Volume: 365, P: 343-347
X-ray structure of a calcium-activated TMEM16 lipid scramblase

The authors describe the structure of a Ca²⁺-activated lipid scramblase which catalyses the passive movement of lipids between the two leaflets of a lipid bilayer; the structure reveals the location of a regulatory calcium-binding site embedded within the membrane and the presence of a hydrophilic membrane-traversing cavity that is exposed to the lipid bilayer, where catalysis is likely to occur.

Janine D. Brunner
Novandy K. Lim
Raimund Dutzler
Research12 Nov 2014
Nature

Volume: 516, P: 207-212
Reciprocal regulation of carbon monoxide metabolism and the circadian clock

Genetic and biochemical assays reveal that carbon monoxide produced by heme catabolism influences circadian rhythm in mammals by altering the activity of transcription factor CLOCK–BMAL1 at clock-gene targets.

Roman Klemz
Silke Reischl
Achim Kramer
Research28 Nov 2016
Nature Structural & Molecular Biology

Volume: 24, P: 15-22
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

Barbara Franke
Jason L Stein
Patrick F Sullivan
Research01 Feb 2016
Nature Neuroscience

Volume: 19, P: 420-431
Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation

Lateral opening of the LptDE transporter in the outer membrane of Gram-negative bacteria is necessary for insertion of lipopolysaccharides. Here, Botte et al. report a cryo-EM structure of a partially opened LptDE transporter, in complex with rigid chaperones derived from nanobodies.

Mathieu Botte
Dongchun Ni
Michael Hennig
ResearchOpen Access05 Apr 2022
Nature Communications

Volume: 13, P: 1-10
MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation

The circadian clock and the cell cycle systems coordinate global physiology. Here the authors show that MYC represses the clock genes, together with MIZ1, and induces proliferation, suggesting that MYC inversely modulates cell cycle and circadian clock genes.

Anton Shostak
Bianca Ruppert
Michael Brunner
ResearchOpen Access24 Jun 2016
Nature Communications

Volume: 7, P: 1-11
Environmental arginine controls multinuclear giant cell metabolism and formation

Multinucleated giant cells (MGCs) are important in the pathogenesis of various diseases. Here, the authors demonstrate that extracellular presence of the amino acid arginine is required for MGC formation and metabolism, suggesting a translational impact for strategies utilizing systemic arginine depletion in MGC-mediated diseases.

Julia S. Brunner
Loan Vulliard
Gernot Schabbauer
ResearchOpen Access22 Jan 2020
Nature Communications

Volume: 11, P: 1-15
Microbial network disturbances in relapsing refractory Crohn’s disease

A disturbed microbial network characterizes relapsing refractory Crohn’s disease and antedates disease recurrence after surgical removal of the active disease segment.

Bahtiyar Yilmaz
Pascal Juillerat
Andrew J. Macpherson
Research21 Jan 2019
Nature Medicine

Volume: 25, P: 323-336
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.

Edith Hofer
Gennady V. Roshchupkin
Sudha Seshadri
ResearchOpen Access22 Sept 2020
Nature Communications

Volume: 11, P: 1-16
Effect of Antipsychotic Withdrawal on Extrapyramidal Symptoms: Statistical Methods for Analyzing Single-Sample Repeated-Measures Data

Stephan Arndt
Charles S. Davis
Nancy C. Andreasen
Research01 Jan 1993
Neuropsychopharmacology

Volume: 8, P: 67-75
Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca²⁺ channel–vesicle coupling

Coupling distances between synaptic vesicles and Ca²⁺ channels determine the efficacy of neurotransmission. Böhme et al. find that presynaptic scaffold complexes spatiotemporally control Unc13 isoforms to establish two independent release pathways at subsynaptic active zones: Unc13B defines nascent, loosely coupled synapses whereas Unc13A facilitates release at mature synapses by tight coupling between Ca²⁺ channels and synaptic vesicles.

Mathias A Böhme
Christina Beis
Stephan J Sigrist
Research15 Aug 2016
Nature Neuroscience

Volume: 19, P: 1311-1320
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Adult forms of inflammatory bowel disease (IBD) are of a polygenic nature, but paediatric and very early onset (VEO) IBD also occur as monogenic forms. Here, using whole exome sequencing, the authors explore both the monogenic and polygenic contribution to VEO-IBD and characterize a rare somatic mosaic VEO-IBD patient.

Eva Gonçalves Serra
Tobias Schwerd
Carl A. Anderson
ResearchOpen Access21 Feb 2020
Nature Communications

Volume: 11, P: 1-15
Publisher Correction: Microbial network disturbances in relapsing refractory Crohn’s disease

Bahtiyar Yilmaz
Pascal Juillerat
Andrew J. Macpherson
Amendments and Corrections07 Mar 2019
Nature Medicine

Volume: 25, P: 701
Gli family members are differentially expressed during the mitotic phase of spermatogenesis

Stephan P Persengiev
Ivanela I Kondova
Daniel L Kilpatrick
Research15 May 1997
Oncogene

Volume: 14, P: 2259-2264
Annealing-inspired training of an optical neural network with ternary weights

Optical neural networks (ONNs) offer a promising alternative to traditional substrates, with improvements in speed and energy efficiency. This work presents a ternary weight semiconductor laserbased ONN, trained with an in-situ optimization algorithm that enhances convergence and performance, demonstrating long-term inference stability above 99%.

Anas Skalli
Mirko Goldmann
Daniel Brunner
ResearchOpen Access13 Feb 2025
Communications Physics

Volume: 8, P: 1-10
Author Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Eva Gonçalves Serra
Tobias Schwerd
Carl A. Anderson
Amendments and CorrectionsOpen Access22 Jun 2022
Nature Communications

Volume: 13, P: 1
Common genetic variants influence human subcortical brain structures

Genome-wide association studies are used to identify common genetic variants that affect the structure of selected subcortical regions of the human brain; their identification provides insight into the causes of variability in brain development and may help to determine mechanisms of neuropsychiatric dysfunction.

Derrek P. Hibar
Jason L. Stein
Sarah E. Medland
Research21 Jan 2015
Nature

Volume: 520, P: 224-229
Gene duplication and exon shuffling by helitron-like transposons generate intraspecies diversity in maize

Michele Morgante
Stephan Brunner
Antoni Rafalski
Research31 Jul 2005
Nature Genetics

Volume: 37, P: 997-1002
Correction to: Solve-RD: systematic pan-European data sharing and collaborative analysis to solve rare diseases

Birte Zurek
Kornelia Ellwanger
Andreas Rump
Amendments and Corrections13 Aug 2021
European Journal of Human Genetics

Volume: 29, P: 1459-1461
Comprehensive reanalysis for CNVs in ES data from unsolved rare disease cases results in new diagnoses

German Demidov
Burcu Yaldiz
Steven Laurie
ResearchOpen Access26 Oct 2024
npj Genomic Medicine

Volume: 9, P: 1-24
Correction: Solving unsolved rare neurological diseases—a Solve-RD viewpoint

Rebecca Schüle
Dagmar Timmann
Andreas Rump
Amendments and Corrections25 Aug 2021
European Journal of Human Genetics

Volume: 29, P: 1462-1465
Bacillamide D produced by Bacillus cereus from the mouse intestinal bacterial collection (miBC) is a potent cytotoxin in vitro

A biosynthetic gene cluster from a Bacillus strain from the mouse gut produces bacillamide D, a selective cytotoxin, inhibiting growth and motility of human cell lines and murine organoids in vitro.

Maximilian Hohmann
Valentina Brunner
Tobias A. M. Gulder
ResearchOpen Access28 May 2024
Communications Biology

Volume: 7, P: 1-11
Oscillatory electroencephalographic patterns of arithmetic problem solving in fourth graders

Clemens Brunner
Nikolaus A. Koren
Stephan E. Vogel
ResearchOpen Access02 Dec 2021
Scientific Reports

Volume: 11, P: 1-13
Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt
Markus Hufnagel
Ulrich Zügge
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-15
Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice

CD98hc in macrophages attenuates the severity of colitis. This change in the macrophage development is associated with increased expression of apoptotic genes, suggesting that CD98hc maintains the gut homeostasis by ensuring the development of gut macrophages.

Philipp Wuggenig
Berna Kaya
Jan Hendrik Niess
ResearchOpen Access18 Mar 2020
Communications Biology

Volume: 3, P: 1-19
Correction to: Solving patients with rare diseases through programmatic reanalysis of genome-phenome data

Leslie Matalonga
Carles Hernández-Ferrer
Andreas Rump
Amendments and Corrections16 Aug 2021
European Journal of Human Genetics

Volume: 29, P: 1466-1469
Solving patients with rare diseases through programmatic reanalysis of genome-phenome data

Leslie Matalonga
Carles Hernández-Ferrer
Andreas Rump
ResearchOpen Access01 Jun 2021
European Journal of Human Genetics

Volume: 29, P: 1337-1347
A novel FRET peptide assay reveals efficient Helicobacter pylori HtrA inhibition through zinc and copper binding

Sabine Bernegger
Cyrill Brunner
Silja Wessler
ResearchOpen Access29 Jun 2020
Scientific Reports

Volume: 10, P: 1-13
Smart, programmable and responsive injectable hydrogels for controlled release of cargo osteoporosis drugs

Konstantinos E. Papathanasiou
Petri Turhanen
Konstantinos D. Demadis
ResearchOpen Access06 Jul 2017
Scientific Reports

Volume: 7, P: 1-9
A comparison of pediatric inflammatory multisystem syndrome temporarily-associated with SARS-CoV-2 and Kawasaki disease

Markus Hufnagel
Jakob Armann
Ulrich Zügge
ResearchOpen Access20 Jan 2023
Scientific Reports

Volume: 13, P: 1-14
Implementation of safe infant sleep recommendations during night-time sleep in the first year of life in a German birth cohort

Vincent D. Gaertner
Sara Fill Malfertheiner
Sebastian Kerzel
ResearchOpen Access17 Jan 2023
Scientific Reports

Volume: 13, P: 1-10
Solve-RD: systematic pan-European data sharing and collaborative analysis to solve rare diseases

Birte Zurek
Kornelia Ellwanger
Andreas Rump
ReviewsOpen Access01 Jun 2021
European Journal of Human Genetics

Volume: 29, P: 1325-1331
Differential centrifugation–based biochemical fractionation of the Drosophila adult CNS

Biochemical methods have typically been underused in Drosophila research owing to technical challenges. Here Depner et al. describe a simple CNS fractionation method that yields ∼4 mg of synaptic membrane protein per 1 g of adult fly heads.

Harald Depner
Janine Lützkendorf
Matthew G Holt
Protocols13 Nov 2014
Nature Protocols

Volume: 9, P: 2796-2808
Solving unsolved rare neurological diseases—a Solve-RD viewpoint

Rebecca Schüle
Dagmar Timmann
Andreas Rump
ReviewsOpen Access10 May 2021
European Journal of Human Genetics

Volume: 29, P: 1332-1336

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