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Public concern about anthropogenic global warming has been declining despite the scientific consensus on the issue. It is still unknown whether experts’ consensus determines people’s beliefs, and it is not clear if public perception of consensus overrides worldviews known to foster rejection of anthropogenic climate change. New research shows that information about scientific consensus increases acceptance of anthropogenic global warming and neutralizes the effect of worldviews.

Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.

Gene therapy is a rapidly growing field, but is hindered by efficacy and safety concerns, including those related to delivery methods. Here, inspired by the use of foam in the delivery of pharmaceuticals, Dr. Stephan and colleagues formulated foam as a safe and effective delivery platform for gene therapy.

RETICULATA1 is a plastid membrane transporter in Arabidopsis that enables basic amino acid exchange across the plastid inner envelope. Loss-of-function mutants reveal its essential role in amino acid homeostasis, plant development and seed production.

This research explores the linguistic traces of evidence-based reasoning and intuitive decision-making in congressional speeches from 1879 to 2022. The analysis suggests that evidence-based language has continued to decline since the mid-1970s, together with a decline in legislative productivity.

Here, the authors sample air and surfaces in hospital rooms of COVID-19 patients, detect SARS-CoV-2 RNA in air samples of two of three tested airborne infection isolation rooms, and find surface contamination in 66.7% of tested rooms during the first week of illness and 20% beyond the first week of illness.

The shape and energy of frontier orbitals determine the reactivity of molecular systems. Combining orbital tomography based on photoelectron spectroscopy with electron diffraction and DFT, the authors investigate a complex multi-configurational adsorbate system revealing adsorptions geometries and hierarchy and geometry of molecular orbitals.

The role of peroxisomes in skeletal muscle remains largely unexplored. Here, the authors show that peroxisomal dysfunction and disrupted crosstalk with mitochondria drive age-related muscle decline, underscoring the need to preserve peroxisomes for muscle health.

The authors identify pathogenic variants in the SMARCA1 gene as the cause of a variable neurodevelopmental disorder. Mouse studies suggest diverse genetic mechanisms related to NURF complex composition mediate the phenotype.

This flagship study from the European Solve-Rare Diseases Consortium presents a diagnostic framework including bioinformatic analysis of clinical, pedigree and genomic data coupled with expert panel review, leading to 500 new diagnoses in a cohort of 6,000 families with suspected rare diseases.

Anaplastic large cell lymphoma (ALCL) is an aggressive T-cell lymphoma often with poor prognosis. To identify genes defining ALCL cell state and dependencies, the authors here characterize ALCL-specific super-enhancers and describe the BATF3/IL-2R−module as a therapeutic opportunity for ALCL.

Bharathan et al. discover that the endoplasmic reticulum associates with keratin intermediate filaments and desmosomal cell–cell junctions, and that desmosomes and the keratin cytoskeleton regulate the distribution, dynamics and function of the endoplasmic reticulum network.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

The poor correlation between brain Aβ deposition and clinical symptoms in Alzheimer´s disease remains puzzling. Here, the authors show a temporal dissociation of Aβ deposition and neurodegeneration.

Extensive oxidative potential measurements from across Europe analysed with the two most common assays, dithiothreitol and ascorbic acid, using a standardized protocol show the strong influence of site type and suggest pathways for mitigation strategies.

Swarte, Zhang and colleagues review the microbiome in solid-organ transplantation and allogeneic haematopoietic-stem-cell transplantation recipients, considering the effects of the intestinal environment, interactions between the microbiota and immunosuppressive drugs, and effects of dysbiosis on transplantation outcomes. The potential of microbiome-targeted interventions to improve transplantation outcomes is also discussed.

How musical expertise impacts the brain’s processing of complex musical information remains unclear. Using generative music models, this study reveals that musicians display enhanced disentangled and contextual neural encoding of music.

Material that accreted to Earth after its core formed largely comprised carbonaceous, volatile-rich meteorites, according to analysis of the selenium isotopic composition of terrestrial mantle rocks.

The L protein of segmented, negative strand RNA viruses contains the RNA-dependent RNA polymerase essential for virus amplification. Here, the authors report cryoEM structures of the Lassa virus L protein in active, RNA-bound states, and provide mechanistic insights.

Using single-cell and spatial transcriptomics on muscle samples from non-ischemic patients and patients with peripheral artery disease (PAD), Turiel et al. identify cellular and molecular changes in the muscle microenvironment during PAD, focusing on endothelial cell–macrophage interactions.

Liver neuroendocrine neoplasms (NEN) without clinically known primary tumor are often classified as primary hepatic NEN. Here, the authors build a classifier accurately predicting the origin sites for NEN based on DNA methylation patterns and show that hepatic NEN with unknown primary tumor are predicted to display a non-hepatic origin.

Gonzalez-Gallego et al. developed a fully iPS-cell-based human three-dimensional blood–brain barrier (BBB) model and used it to study roles of the stroke risk gene FOXF2 in BBB dysregulation, demonstrating its applicability for mechanistic research and drug development.

Anomalous aortic origin of the coronary artery (AAOCA) is a rare cardiac condition that is often falsely classified in routine coronary CT angiography (CCTA). Here the authors developed an AI-based tool was developed to detect and classify AAOCA in CT images with high accuracy to improve management of this condition.

This study explores the use of quantum computing to address multi-objective optimization challenges. By using a low-depth quantum approximate optimization algorithm to approximate the optimal Pareto front of multi-objective weighted max-cut problems, the authors demonstrate promising results—both in simulation and on IBM Quantum hardware—surpassing classical approaches.

One carbon compounds such as CO₂, methanol and formate are cost-effective and environmentally friendly microbial feedstocks for biomanufacturing. Here, the authors report the oxygen tolerant reductive glycine pathway in Komagataella phaffii can co-assimilate CO₂, methanol and formate.

Here, the authors explore the blue photoluminescence signal arising from the interface between graphene and h-BN arranged in in-plane heterostructures, and fabricate a blue light emitting device utilizing the heterojunction as the emitting layer.

The LKB1/AMPK is crucial for maintaining cellular homeostasis and is often deregulated in tumours. Here, the authors show that the ribosylation of LKB1 by tankyrase-RNF146 axis results in attenuation of LKB1 pathway activation.

A connectome of the right optic lobe from a male fruitfly is presented together with an extensive collection of genetic drivers matched to a comprehensive neuron-type catalogue.

Current widely used viral and electroporation methods for creating therapeutic cell-based products are complex and expensive. Here, the authors develop targeted mRNA nanocarriers that can transiently program gene expression by simply mixing them with cells, to improve their therapeutic potential.

The conserved eukaryotic heterotrimeric NatC complex co-translationally acetylates the N-termini of numerous target proteins. Here, the authors provide insights into the catalytic mechanism of NatC by determining the crystal structures of Saccharomyces cerevisiae NatC in the absence and presence of cofactors and peptide substrates and reveal the molecular basis of substrate binding by further biochemical analyses.

The authors present μeV electron spectromicroscopy, a technique that combines free-space light and electron beams to achieve unmatched spatial and spectral resolution. This approach enables detailed investigation of photonic structures, promising advancements in microscopy and quantum optics.

Citric and oxalic acids can enhance the dissolution of chromium(III) under strongly reducing conditions where relatively high levels of ferrous iron are present, according to laboratory-controlled batch dissolution and flow-through column experiments on soils and sediments.

The authors integrate artificial intelligence with laboratory automation to create a widely applicable autonomous platform for efficient and scalable enzyme engineering.

There are currently no licensed vaccines to prevent Group A Streptococcus (GAS) infections. In this study, the authors evaluate the immune response and preclinical efficacy of a multicomponent mRNA lipid-nanoparticle vaccine against GAS.

The shape of biological matter is central to their function and interaction with other cellular components. A combination of DNA origami nanorafts with biogenic pores reversibly controls the shape and permeability of lipid vesicles at the microscale.

The authors evaluate heritable genetic variation in thermal tolerance in a common reef-building coral. They show widespread heritable genetic variation, which is strongly associated with marine heatwave-imposed selective pressure, suggesting adaptation to climate warming.

Using a new computational pipeline for identification of drug-selective transcriptomic responses and FAERS data, the authors identified potential pathways and genomic variants indicative of cancer drug cardiotoxicity in iPSC-derived cardiomyocytes.

Avocado fatty alcohols/acetates (AFAs) are effective against parasitic nematodes, including drug resistant strains, and show safety in mammalian cells. AFAs target lipid metabolism, offering the potential for new anthelmintic treatment pathways.

In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.

Near-field body area wearable sensing networks are limited in application due to the low spectral stability against external interference. Here, the authors demonstrate a robust metamaterial-enabled near-field body area network that maintains spectral stability even under lossy and conductive loadings.