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Showing 1–9 of 9 results
Advanced filters: Author: Stephen McAdoo Clear advanced filters

  • This Review discusses the advances and challenges of managing antineutrophil cytoplasmic antibody-associated vasculitis. The authors discuss current treatment options, emerging therapies and unmet needs in the management of this disease.

    • Giorgio Trivioli
    • Marta Casal Moura
    • David R. W. Jayne
    Reviews
    Nature Reviews Rheumatology
    Volume: 21, P: 396-413

  • End-stage kidney disease confers a high risk for severe COVID-19 infection. Using an at-risk group (end-stage kidney disease patients with COVID-19), authors using RNA-sequencing of immune cells and plasma proteomic profiling to investigate the host response to viral infection.

    • Jack S. Gisby
    • Norzawani B. Buang
    • James E. Peters
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21

  • Serological analysis and infection outcomes of participants in the multi-center, prospectively enrolled OCTAVE cohort, comprising 2,686 participants with immune-suppressive diseases who recieved two COVID-19 vaccines, reveals specific clinical phenotypes that might benefit from specific COVID-19 therapeutic strategies.

    • Eleanor Barnes
    • Carl S. Goodyear
    • Deborah Richardson
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 1760-1774

  • BCATs catabolize leucine and other BCAAs. Here the authors show that BCAA metabolism affects the broken Krebs cycle, reprogramming macrophages to be less proinflammatory, and show that BCAT1 inhibitor ERG240 can treat arthritis in mice and glomerulonephritis in rats.

    • Adonia E. Papathanassiu
    • Jeong-Hun Ko
    • Jacques Behmoaras
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • Glucocorticoids have, for decades, been an enduring component of treatment regimens for anti-neutrophil cytoplasm autoantibody (ANCA)-associated vasculitis. However, a growing number of studies have encouraged a move towards reduced glucocorticoid usage. Findings of the ADVOCATE trial suggest that complement blockade may pave the way for complete glucocorticoid avoidance.

    • Maria Prendecki
    • Stephen P. McAdoo
    News & Views
    Nature Reviews Nephrology
    Volume: 17, P: 439-440

  • Vaccination against SARS-CoV-2 seems to be safe in patients with immunity-mediated kidney disease, although their immunological responses to vaccination are impaired. Further strategies, including the administration of additional vaccine doses and passive immunization with long-acting monoclonal antibodies, might increase protection in this vulnerable patient group.

    • Maria Prendecki
    • Michelle Willicombe
    • Stephen P. McAdoo
    Comments & Opinion
    Nature Reviews Nephrology
    Volume: 17, P: 790-791

  • Large-vessel vasculitis is the most common primary vasculitis in adults, manifesting as inflammation of the aorta and its major branches. This Primer reviews the epidemiology, pathophysiology, diagnosis and management of this disease, highlights its effects on patient quality of life, and discusses future research questions.

    • Dan Pugh
    • Maira Karabayas
    • Neeraj Dhaun
    Reviews
    Nature Reviews Disease Primers
    Volume: 7, P: 1-23