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Showing 1–10 of 10 results

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Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation

Merlin et al. find that non-canonical glutamine transamination is required for macrophage efferocytosis in atherosclerotic plaques by sustaining redox buffering and fueling energy production for cytoskeletal rearrangements.

Johanna Merlin
Stoyan Ivanov
Laurent Yvan-Charvet
Research14 Oct 2021
Nature Metabolism

Volume: 3, P: 1313-1326
Topographical representations of mental images in primary visual cortex

Stephen M. Kosslyn
William L. Thompson
Nathaniel M. Alpert
Research30 Nov 1995
Nature

Volume: 378, P: 496-498
Dopamine promotes aggression in mice via ventral tegmental area to lateral septum projections

The authors show that terminal activity of dopaminergic neurons selectively projecting from the ventral tegmental area to the lateral septum is sufficient for promoting aggression and necessary for establishing baseline aggression in mice.

Darshini Mahadevia
Rinki Saha
Mark S. Ansorge
ResearchOpen Access23 Nov 2021
Nature Communications

Volume: 12, P: 1-12
Identifying strategies to target the metabolic flexibility of tumours

Metabolic compensation equips tumours with the plasticity to circumvent individual nutrient pathway perturbation. Méndez-Lucas et al. demonstrate the power of synergistic targeting of multiple metabolic pathways to stymie liver tumourigenesis.

Andrés Méndez-Lucas
Wei Lin
Mariia Yuneva
Research21 Apr 2020
Nature Metabolism

Volume: 2, P: 335-350
Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia

In NOTCH-induced T cell acute lymphoblastic leukemia, the resistance to anti-NOTCH therapy conferred by loss of the Pten tumor suppressor is linked to reversal of the effects of NOTCH inhibition on leukemic cell metabolism.

Daniel Herranz
Alberto Ambesi-Impiombato
Adolfo A Ferrando
Research21 Sept 2015
Nature Medicine

Volume: 21, P: 1182-1189
Glutaminase-Deficient Mice Display Hippocampal Hypoactivity, Insensitivity to Pro-Psychotic Drugs and Potentiated Latent Inhibition: Relevance to Schizophrenia

Inna Gaisler-Salomon
Gretchen M Miller
Stephen Rayport
Research10 Jun 2009
Neuropsychopharmacology

Volume: 34, P: 2305-2322
Dopamine transporter blockade during adolescence increases adult dopamine function, impulsivity, and aggression

Deepika Suri
Giulia Zanni
Mark S. Ansorge
ResearchOpen Access02 Aug 2023
Molecular Psychiatry

Volume: 28, P: 3512-3523
Perinatal interference with the serotonergic system affects VTA function in the adult via glutamate co-transmission

Catarina Cunha
John F. Smiley
Catia M. Teixeira
Research12 May 2020
Molecular Psychiatry

Volume: 26, P: 4795-4812
5-HT2C receptor blockade reverses SSRI-associated basal ganglia dysfunction and potentiates therapeutic efficacy

Elena Y. Demireva
Deepika Suri
Mark S. Ansorge
Research17 Aug 2018
Molecular Psychiatry

Volume: 25, P: 3304-3321
Impact of D2 Receptor Internalization on Binding Affinity of Neuroimaging Radiotracers

Ningning Guo
Wen Guo
Stephen Rayport
Research02 Dec 2009
Neuropsychopharmacology

Volume: 35, P: 806-817