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Macrophage-T cell interactions promote SLAMF1 expression for enhanced TB defense

CD4⁺ T cells promote immunity to tuberculosis infection via macrophages. Here the authors show upregulation of SLAMF1/CD150 on infected macrophages after interaction with CD4⁺ T cells and that the presence of SLAMF1 promotes ROS production by macrophages and the absence of Slamf1 in macrophages results in higher mycobacterial loads in infected mice.

G. V. R. Krishna Prasad
Steven J. Grigsby
Jennifer A. Philips
ResearchOpen Access23 Jul 2025
Nature Communications

Volume: 16, P: 1-17
Rapid selection of complement-inhibiting protein variants in group A Streptococcus epidemic waves

Nancy P. Hoe
Kazumitsu Nakashima
James M. Musser
Research01 Aug 1999
Nature Medicine

Volume: 5, P: 924-929
Immune evasion and provocation by Mycobacterium tuberculosis

In this Review, Chandra, Grigsby and Philips discuss how Mycobacterium tuberculosis evades immune-mediated clearance while capitalizing on the host inflammatory response at different phases of its life cycle. They focus on recent studies, highlight gaps in knowledge and consider how our current understanding will inform new therapies, vaccines and diagnostics.

Pallavi Chandra
Steven J. Grigsby
Jennifer A. Philips
Reviews25 Jul 2022
Nature Reviews Microbiology

Volume: 20, P: 750-766
Integrated genomic and molecular characterization of cervical cancer

This paper describes molecular subtypes of cervical cancers, including squamous cell carcinoma and adenocarcinoma clusters defined by HPV status and molecular features, and distinct molecular pathways that are activated in cervical carcinomas caused by different somatic alterations and HPV types.

Robert D. Burk
Zigui Chen
David Mutch
ResearchOpen Access23 Jan 2017
Nature

Volume: 543, P: 378-384
Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection

The response to infectious and inflammatory challenges differs among people but the reasons for this are poorly understood. Here the authors explore the impact of variables such as age, sex, and the capacity for controlling inflammation and maintaining immunocompetence, linking this capacity to favourable health outcomes and lifespan.

Sunil K. Ahuja
Muthu Saravanan Manoharan
Weijing He
ResearchOpen Access13 Jun 2023
Nature Communications

Volume: 14, P: 1-31
Cannabis use and measurement of cannabinoids in plasma and breast milk of breastfeeding mothers

Michael J. Moss
Ittai Bushlin
Tamara M. Grigsby
Research19 Jan 2021
Pediatric Research

Volume: 90, P: 861-868

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Macrophage-T cell interactions promote SLAMF1 expression for enhanced TB defense

Rapid selection of complement-inhibiting protein variants in group A Streptococcus epidemic waves

Immune evasion and provocation by Mycobacterium tuberculosis

Integrated genomic and molecular characterization of cervical cancer

Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection

Cannabis use and measurement of cannabinoids in plasma and breast milk of breastfeeding mothers

Search

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Macrophage-T cell interactions promote SLAMF1 expression for enhanced TB defense

Rapid selection of complement-inhibiting protein variants in group A Streptococcus epidemic waves

Immune evasion and provocation by Mycobacterium tuberculosis

Integrated genomic and molecular characterization of cervical cancer

Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection

Cannabis use and measurement of cannabinoids in plasma and breast milk of breastfeeding mothers

Search

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