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Showing 1–8 of 8 results
Advanced filters: Author: Steven M. Gilbertson Clear advanced filters

  • Medulloblastomas are the most common malignant childhood brain tumours and are thought to arise from the cerebellum. There is substantial heterogeneity among medulloblastomas and some are thought to arise following aberrant Sonic Hedgehog pathway activation. It is now shown that a distinct subtype of medulloblastoma arises from the dorsal brainstem and is associated with altered WNT signalling. Distinct molecular and clinical profiles of the subtypes have implications for future treatment.

    • Paul Gibson
    • Yiai Tong
    • Richard J. Gilbertson
    Research
    Nature
    Volume: 468, P: 1095-1099

  • Whole-genome sequencing of medulloblastoma samples reveals several recurrent mutations in genes not previously implicated in the disease, many of which affect components of the epigenetic machinery in different disease subgroups.

    • Giles Robinson
    • Matthew Parker
    • Richard J. Gilbertson
    ResearchOpen Access
    Nature
    Volume: 488, P: 43-48

  • A combination of secondary structure probing and RNA crosslinking sequencing approaches sheds lights on the RNA conformations and the intra- and intersegment interactions of the genome inside influenza A virions.

    • Bernadeta Dadonaite
    • Brad Gilbertson
    • David L. V. Bauer
    Research
    Nature Microbiology
    Volume: 4, P: 1781-1789

  • Turnip mosaic virusinfection increases the performance of aphid vectors on host plants. Here the authors show that this phenomenon requires relocalization of a viral protease to host cell vacuoles and that this only occurs when aphids are present, suggesting a viral protein responds dynamically to a vector.

    • Aurélie Bak
    • Andrea L. Cheung
    • Clare L. Casteel
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • Brain cancer encompasses a diverse range of complex malignancies, many of which are associated with a poor prognosis and require more effective treatments. In this Position Paper, an international panel of clinicians and laboratory-based scientists convened by Cancer Research UK identify and discuss seven challenges that must be overcome if we are to cure all patients with a brain tumour.

    • Kenneth Aldape
    • Kevin M. Brindle
    • Richard J. Gilbertson
    ReviewsOpen Access
    Nature Reviews Clinical Oncology
    Volume: 16, P: 509-520