Nature Search

Molecular damage in aging

In this Review, the authors discuss the concept of molecular damage in aging, from theoretical models to experimental approaches and how to test interventions targeting aging that reduce its burden.

Vadim N. Gladyshev
Stephen B. Kritchevsky
Steven R. Cummings
Reviews20 Dec 2021
Nature Aging

Volume: 1, P: 1096-1106
miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β

Colorectal cancer (CRC), like many solid tumours, progresses from adenomas to carcinomas in a sequence that leads to metastasis. Here the authors show that miR1269 plays a role in CRC relapse and metastasis by regulating TGF-β activity.

Pengcheng Bu
Lihua Wang
Xiling Shen
Research15 Apr 2015
Nature Communications

Volume: 6, P: 1-12
The role of polygenic risk and susceptibility genes in breast cancer over the course of life

Identifying women at high risk of breast cancer has important implications for screening. Here, the authors demonstrate that polygenic risk scores improve breast cancer risk prediction in the population, in women with mutations in high-risk genes and in women with close relatives with the disease.

Nina Mars
Elisabeth Widén
Samuli Ripatti
ResearchOpen Access14 Dec 2020
Nature Communications

Volume: 11, P: 1-9
Genome sequence of the human malaria parasite Plasmodium falciparum

Malcolm J. Gardner
Neil Hall
Bart Barrell
Research03 Oct 2002
Nature

Volume: 419, P: 498-511
Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

M. Carola Zillikens
Serkalem Demissie
Douglas P. Kiel
Amendments and CorrectionsOpen Access07 Nov 2017
Nature Communications

Volume: 8, P: 1-4
Erratum: A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis

Manuel A. Rivas
Daniel Graham
Mark J. Daly
Amendments and CorrectionsOpen Access13 Sept 2016
Nature Communications

Volume: 7, P: 1
Dynamic landscape and regulation of RNA editing in mammals

Using the GTEx data and others, a comprehensive analysis of adenosine-to-inosine RNA editing in mammals is presented; targets of the various ADAR enzymes are identified, as are several potential regulators of editing, such as AIMP2.

Meng How Tan
Qin Li
Jin Billy Li
Research12 Oct 2017
Nature

Volume: 550, P: 249-254
Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes

Siwei Chen
Laurent C. Francioli
Konrad J. Karczewski
Amendments and Corrections15 Jan 2024
Nature

Volume: 626, P: E1
Bacterial glycosidases for the production of universal red blood cells

Qiyong P Liu
Gerlind Sulzenbacher
Henrik Clausen
Research01 Apr 2007
Nature Biotechnology

Volume: 25, P: 454-464
Mining the O-glycoproteome using zinc-finger nuclease–glycoengineered SimpleCell lines

Owing to a lack of tools and a lack of a consensus sequence for O-glycosylation, studies of the O-glycoproteome have been few and far between, despite the biological importance of O-glycosylation. This method to analyze O-glycan attachment sites to proteins using glycoengineered cell lines with simplified, homogenous O-glycoproteomes should facilitate future O-glycoproteomics studies.

Catharina Steentoft
Sergey Y Vakhrushev
Henrik Clausen
Research09 Oct 2011
Nature Methods

Volume: 8, P: 977-982
The impact of rare variation on gene expression across tissues

The authors show that rare genetic variants contribute to large gene expression changes across diverse human tissues and provide an integrative method for interpretation of rare variants in individual genomes.

Xin Li
Yungil Kim
Stephen B. Montgomery
ResearchOpen Access12 Oct 2017
Nature

Volume: 550, P: 239-243
Publisher Correction: A meta-analysis of genome-wide association studies identifies multiple longevity genes

Joris Deelen
Daniel S. Evans
Joanne M. Murabito
Amendments and CorrectionsOpen Access23 Apr 2021
Nature Communications

Volume: 12, P: 1
The tomato genome sequence provides insights into fleshy fruit evolution

This paper reports the genome sequence of domesticated tomato, a major crop plant, and a draft sequence for its closest wild relative; comparative genomics reveal very little divergence between the two genomes but some important differences with the potato genome, another important food crop in the genus Solanum.

Shusei Sato
Satoshi Tabata
René M. Klein Lankhorst
ResearchOpen Access30 May 2012
Nature

Volume: 485, P: 635-641
The Amazon rain forest plant Uncaria tomentosa (cat’s claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles

Alan D. Snow
Gerardo M. Castillo
Lesley Larsen
ResearchOpen Access06 Feb 2019
Scientific Reports

Volume: 9, P: 1-28
Challenges and recommendations for the translation of biomarkers of aging

Biomarkers of aging have potential to accelerate the clinical translation of interventions that promote healthy aging but are currently limited to research. The authors identify six barriers to be overcome to enable biomarker translation, providing a roadmap to clinical implementation.

Chiara M. S. Herzog
Ludger J. E. Goeminne
Vadim N. Gladyshev
Reviews16 Sept 2024
Nature Aging

Volume: 4, P: 1372-1383
Author Correction: Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals

Nicola Whiffin
Konrad J. Karczewski
James S. Ware
Amendments and CorrectionsOpen Access02 Feb 2021
Nature Communications

Volume: 12, P: 1
Neutrophil extracellular trap gene expression signatures identify prognostic and targetable signaling axes for inhibiting pancreatic tumour metastasis

A Neutrophil Extracellular Trap (NET) associated gene expression signature is identified for Pancreatic Ductal Adenocarcinoma progression. NETS stimulate a CCDC25-ITGB1-ILK mediated signaling pathways that promote tumor invasion and metastasis.

Paul C. McDonald
James T. Topham
Shoukat Dedhar
ResearchOpen Access04 Jul 2025
Communications Biology

Volume: 8, P: 1-19
Validation of biomarkers of aging

Robust validation of biomarkers of aging will be critical to their clinical translation; here, authors review the key challenges and propose recommendations to overcome them.

Mahdi Moqri
Chiara Herzog
Luigi Ferrucci
Reviews14 Feb 2024
Nature Medicine

Volume: 30, P: 360-372
MiRNA-15b and miRNA-125b are associated with regional Aβ-PET and FDG-PET uptake in cognitively normal individuals with subjective memory complaints

Andrea Vergallo
Simone Lista
José L. Zugaza
ResearchOpen Access27 Jan 2021
Translational Psychiatry

Volume: 11, P: 1-11
The TOPAZ study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism

Caroline M. Tanner
Steven R. Cummings
Kenneth W. Lyles
ResearchOpen Access01 Mar 2021
npj Parkinson's Disease

Volume: 7, P: 1-6
Author Correction: A structural variation reference for medical and population genetics

Ryan L. Collins
Harrison Brand
Michael E. Talkowski
Amendments and CorrectionsOpen Access03 Feb 2021
Nature

Volume: 590, P: E55
Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers

Integrated systems analysis on mouse liver proteomic and transcriptomic data of multiple lifespan-extending interventions highlights the overarching biological processes involved in aging and longevity.

Kengo Watanabe
Tomasz Wilmanski
Noa Rappaport
ResearchOpen Access22 Jul 2023
Communications Biology

Volume: 6, P: 1-15
Mendelian randomisation study of smoking exposure in relation to breast cancer risk

Hanla A. Park
Sonja Neumeyer
Jenny Chang-Claude
ResearchOpen Access02 Aug 2021
British Journal of Cancer

Volume: 125, P: 1135-1145
Postmenopausal osteoporosis

Osteoporosis is a metabolic bone disorder that is characterized by low bone mass and micro-architectural deterioration of bone tissue. In this Primer, Eastell et al. discuss the epidemiology and pathophysiology of postmenopausal osteoporosis and consider its diagnosis, prevention and treatment and its effect on quality of life.

Richard Eastell
Terence W. O'Neill
Steven R. Cummings
Reviews29 Sept 2016
Nature Reviews Disease Primers

Volume: 2, P: 1-16
CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Nichola Johnson
Sarah Maguire
Olivia Fletcher
ResearchOpen Access26 Jan 2021
British Journal of Cancer

Volume: 124, P: 842-854
Genetic variants in RBFOX3 are associated with sleep latency

Najaf Amin
Karla V Allebrandt
Cornelia M van Duijn
Research04 May 2016
European Journal of Human Genetics

Volume: 24, P: 1488-1495
Deep learning predicts all-cause mortality from longitudinal total-body DXA imaging

Glaser et al. develop a deep learning system to predict all-cause mortality from total-body DXA scans. Their best predictive model integrates longitudinal body composition data with traditional mortality risk factors.

Yannik Glaser
John Shepherd
Steven R. Cummings
ResearchOpen Access16 Aug 2022
Communications Medicine

Volume: 2, P: 1-12
Rapid progression of prostate cancer in men with a BRCA2 mutation

S A Narod
S Neuhausen
P Sun
ResearchOpen Access24 Jun 2008
British Journal of Cancer

Volume: 99, P: 371-374
Mitochondrial DNA m.3243A > G heteroplasmy affects multiple aging phenotypes and risk of mortality

Gregory J. Tranah
Shana M. Katzman
Steven R. Cummings
ResearchOpen Access08 Aug 2018
Scientific Reports

Volume: 8, P: 1-9
Deciphering the genetics of hereditary non-syndromic colorectal cancer

Eli Papaemmanuil
Luis Carvajal-Carmona
Ian Tomlinson
Research16 Jul 2008
European Journal of Human Genetics

Volume: 16, P: 1477-1486
Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis

A genome-wide association study identifies MFGE8 as protective against coronary atherosclerosis in European and East Asian populations.

Sanni E. Ruotsalainen
Ida Surakka
Samuli Ripatti
ResearchOpen Access17 Aug 2022
Communications Biology

Volume: 5, P: 1-16
Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes

Max Tamlander et al. combine polygenic risk scores and clinical assessments to improve prediction of coronary artery disease and type 2 diabetes in European cohorts. Taken together, their results provide a useful method for preliminary cardiometabolic risk assessment in patients.

Max Tamlander
Nina Mars
Samuli Ripatti
ResearchOpen Access23 Feb 2022
Communications Biology

Volume: 5, P: 1-13
Author Correction: Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers

Kengo Watanabe
Tomasz Wilmanski
Noa Rappaport
Amendments and CorrectionsOpen Access27 Nov 2023
Communications Biology

Volume: 6, P: 1
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies

T J Key
P N Appleby
H D Strickler
ResearchOpen Access19 Jul 2011
British Journal of Cancer

Volume: 105, P: 709-722

Search

Molecular damage in aging

miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β

The role of polygenic risk and susceptibility genes in breast cancer over the course of life

Genome sequence of the human malaria parasite Plasmodium falciparum

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

Erratum: A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis

Dynamic landscape and regulation of RNA editing in mammals

Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes

Bacterial glycosidases for the production of universal red blood cells

Mining the O-glycoproteome using zinc-finger nuclease–glycoengineered SimpleCell lines

The impact of rare variation on gene expression across tissues

Publisher Correction: A meta-analysis of genome-wide association studies identifies multiple longevity genes

The tomato genome sequence provides insights into fleshy fruit evolution

The Amazon rain forest plant Uncaria tomentosa (cat’s claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles

Challenges and recommendations for the translation of biomarkers of aging

Author Correction: Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals

Neutrophil extracellular trap gene expression signatures identify prognostic and targetable signaling axes for inhibiting pancreatic tumour metastasis

Validation of biomarkers of aging

MiRNA-15b and miRNA-125b are associated with regional Aβ-PET and FDG-PET uptake in cognitively normal individuals with subjective memory complaints

The TOPAZ study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism

Author Correction: A structural variation reference for medical and population genetics

Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers

Mendelian randomisation study of smoking exposure in relation to breast cancer risk

Postmenopausal osteoporosis

CYP3A71C* allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Genetic variants in RBFOX3 are associated with sleep latency

Deep learning predicts all-cause mortality from longitudinal total-body DXA imaging

Rapid progression of prostate cancer in men with a BRCA2 mutation

Mitochondrial DNA m.3243A > G heteroplasmy affects multiple aging phenotypes and risk of mortality

Deciphering the genetics of hereditary non-syndromic colorectal cancer

Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis

Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes

Author Correction: Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies

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