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Showing 1–50 of 58 results

Advanced filters: Author: Steven Talbot Clear advanced filters

Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to altered dysbindin-1 gene expression

Junxia Tang
Robert LeGros
Konrad Talbot
ResearchOpen Access13 Jan 2009
Nature Precedings

P: 1
Editorial Expression of Concern: Altered neuregulin 1–erbB4 signaling contributes to NMDA> receptor hypofunction in schizophrenia

Chang-Gyu Hahn
Hoau-Yan Wang
Steven E Arnold
Amendments and Corrections19 Dec 2023
Nature Medicine

Volume: 30, P: 911
Dysregulation of Specialized Delay/Interference-Dependent Working Memory Following Loss of Dysbindin-1A in Schizophrenia-Related Phenotypes

Emilie I Petit
Zuzanna Michalak
John L Waddington
Research16 Dec 2016
Neuropsychopharmacology

Volume: 42, P: 1349-1360
Improving pain management for murine orthotopic xenograft models of acute lymphoblastic leukemia

By assessing different clinical, behavioral and welfare parameters, the authors demonstrate that the oral administration of tramadol is more suitable than metamizole as on-demand analgesia in mouse models of acute lymphoblastic leukemia.

Tim Schreiber
Sandra Lange
Simone Kumstel
ResearchOpen Access08 Oct 2025
Lab Animal

P: 1-8
Spatial and temporal analysis of West Nile virus infection in mosquito and human populations based on arboviral detection testing data

Benoit Talbot
Antoinette Ludwig
Manisha A. Kulkarni
ResearchOpen Access28 Dec 2024
Scientific Reports

Volume: 14, P: 1-15
Data Correction of Intensity Modulated Small Angle Scattering

Fankang Li
Steven R. Parnell
Roger Pynn
ResearchOpen Access12 Jun 2019
Scientific Reports

Volume: 9, P: 1-8
Directionality of developing skeletal muscles is set by mechanical forces

The mechanisms that drive myocyte orientation and fusion to control muscle directionality are not well understood. Here authors show that the developing skeleton produces mechanical tension that instructs the directional outgrowth of skeletal muscles.

Kazunori Sunadome
Alek G. Erickson
Igor Adameyko
ResearchOpen Access27 May 2023
Nature Communications

Volume: 14, P: 1-24
EUV-induced hydrogen desorption as a step towards large-scale silicon quantum device patterning

Scanning tunnelling microscopy-based H desorption lithography is used for atomic-scale patterning of quantum devices in Si, but its time-consuming nature hinders scalability. Here the authors report H desorption from Si(001):H surface using extreme-UV light and explore implications for patterning.

Procopios Constantinou
Taylor J. Z. Stock
Steven R. Schofield
ResearchOpen Access24 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Correction: Corrigendum: Mutations in FRMD7, a newly identified member of the FERM family, cause X-linked idiopathic congenital nystagmus

Patrick Tarpey
Shery Thomas
Irene Gottlob
Amendments and Corrections28 Jun 2011
Nature Genetics

Volume: 43, P: 720
The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment

The ATR inhibitor ceralasertib has shown clinical activity in combination with immune-checkpoint inhibitors in several cancer types. Here the authors report the anti-tumor activity and the immunomodulatory changes, dependent on up-regulation of type I interferon pathway, following intermittent ATR inhibition in preclinical cancer models.

Elizabeth L. Hardaker
Emilio Sanseviero
Simon T. Barry
ResearchOpen Access24 Feb 2024
Nature Communications

Volume: 15, P: 1-20
Altered neuregulin 1–erbB4 signaling contributes to NMDA> receptor hypofunction in schizophrenia

Chang-Gyu Hahn
Hoau-Yan Wang
Steven E Arnold
Research11 Jun 2006
Nature Medicine

Volume: 12, P: 824-828
Exploring dose–response variability and relative severity assessment in STZ-induced diabetes male NSG mice

Steven R. Talbot
Miriam Heider
Ortwin Naujok
ResearchOpen Access17 Jul 2024
Scientific Reports

Volume: 14, P: 1-11
Correction: Investigating dopaminergic abnormalities in schizophrenia and first-episode psychosis with normative modelling and multisite molecular neuroimaging

Alessio Giacomel
Daniel Martins
Luke Vano
Amendments and CorrectionsOpen Access31 Mar 2025
Molecular Psychiatry

Volume: 30, P: 3856
Single-Shot Multi-Frame Imaging of Cylindrical Shock Waves in a Multi-Layered Assembly

Leora Dresselhaus-Cooper
Joshua E. Gorfain
Keith A. Nelson
ResearchOpen Access06 Mar 2019
Scientific Reports

Volume: 9, P: 1-12
A database of chlorophyll a in Australian waters

Claire H. Davies
Penelope Ajani
Anthony J. Richardson
ResearchOpen Access20 Feb 2018
Scientific Data

Volume: 5, P: 1-8
In vivo adenine base editing reverts C282Y and improves iron metabolism in hemochromatosis mice

Hemochromatosis is a metabolic disorder caused by mutations in the HFE gene. Here, the authors show that a single administration of AAV8 vectors expressing an Adenine Base Editor facilitates efficient in vivo gene correction in hepatocytes and leads to improvement of iron-specific parameters in the liver and the blood in mouse models of the disease.

Alice Rovai
BoMee Chung
Michael Ott
ResearchOpen Access05 Sept 2022
Nature Communications

Volume: 13, P: 1-10
Comparing distress of mouse models for liver damage

Guanglin Tang
Nico Seume
Dietmar Zechner
ResearchOpen Access13 Nov 2020
Scientific Reports

Volume: 10, P: 1-12
Mutations in FRMD7, a newly identified member of the FERM family, cause X-linked idiopathic congenital nystagmus

Patrick Tarpey
Shery Thomas
Irene Gottlob
Research01 Oct 2006
Nature Genetics

Volume: 38, P: 1242-1244
Author Correction: Exploring dose–response variability and relative severity assessment in STZ-induced diabetes male NSG mice

Steven R. Talbot
Miriam Heider
Ortwin Naujok
Amendments and CorrectionsOpen Access22 Apr 2025
Scientific Reports

Volume: 15, P: 1
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage

Michael C. Zody
Manuel Garber
Chad Nusbaum
Research01 Apr 2006
Nature

Volume: 440, P: 1045-1049
Low prevalence of the APC I1307K sequence in Jewish and non-Jewish patients with inflammatory bowel disease

Jing Yin
Noam Harpaz
Stephen J Meltzer
Research14 Jul 1999
Oncogene

Volume: 18, P: 3902-3904
Widespread deoxygenation of temperate lakes

Analysis of temperate lakes finds a widespread decline in dissolved oxygen concentrations in surface and deep waters, which is associated with reduced solubility at warmer surface water temperatures and increased stratification at depth.

Stephen F. Jane
Gretchen J. A. Hansen
Kevin C. Rose
Research02 Jun 2021
Nature

Volume: 594, P: 66-70
Investigating dopaminergic abnormalities in schizophrenia and first-episode psychosis with normative modelling and multisite molecular neuroimaging

Alessio Giacomel
Daniel Martins
Luke Vano
ResearchOpen Access28 Feb 2025
Molecular Psychiatry

Volume: 30, P: 3533-3550
Perception of a divergent family of phytocytokines by the Arabidopsis receptor kinase MIK2

Secreted peptides and cell-surface localized receptor kinases allow plants to modify growth and development according to external cues. Here, Rhodes et al. show that the MIK2 receptor perceives the SERINE RICH ENDOGENOUS PEPTIDE (SCOOP) family of phytocytokines and is capable of recognising Fusarium-derived SCOOP-like peptides.

Jack Rhodes
Huanjie Yang
Cyril Zipfel
ResearchOpen Access29 Jan 2021
Nature Communications

Volume: 12, P: 1-10
Quantitative phase imaging endoscopy with a metalens

Metalens with typical chromatic aberrations, when attached to the distal tip of a conventional endoscope, simultaneously encodes different depths into the RGB channels of a camera at the proximal end.

Aamod Shanker
Johannes E. Fröch
Arka Majumdar
ResearchOpen Access08 Nov 2024
Light: Science & Applications

Volume: 13, P: 1-14
Digitalization impacts the COVID-19 pandemic and the stringency of government measures

Helen Heinrichs
Florian Mueller
Fabian Kiessling
ResearchOpen Access14 Dec 2022
Scientific Reports

Volume: 12, P: 1-13
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Primary biliary cirrhosis is an autoimmune liver disease with poor therapeutic options. Here Cordell et al. a perform meta-analysis of European genome-wide association studies identifying six novel risk loci and a number of potential therapeutic pathways.

Heather J. Cordell
Younghun Han
Katherine A. Siminovitch
ResearchOpen Access22 Sept 2015
Nature Communications

Volume: 6, P: 1-11
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

Philippe Bégin
Jeannie Callum
Donald M. Arnold
ResearchOpen Access09 Sept 2021
Nature Medicine

Volume: 27, P: 2012-2024
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

Malcolm G Dunlop
Sara E Dobbins
Richard S Houlston
Research27 May 2012
Nature Genetics

Volume: 44, P: 770-776
Past penguin colony responses to explosive volcanism on the Antarctic Peninsula

Changes in penguin populations on the Antarctic Peninsula in recent decades have been linked to environmental factors such as sea ice. Here, the authors show that penguin colony change on Ardley Island, NW Antarctic Peninsula during the last 8,500 years was primarily driven by volcanic activity.

Stephen J. Roberts
Patrick Monien
Dominic A. Hodgson
ResearchOpen Access11 Apr 2017
Nature Communications

Volume: 8, P: 1-16
The DNA sequence of the human X chromosome

Mark T. Ross
Darren V. Grafham
David R. Bentley
Research17 Mar 2005
Nature

Volume: 434, P: 325-337
The DNA sequence, annotation and analysis of human chromosome 3

Donna M. Muzny
Steven E. Scherer
Richard A. Gibbs
Research27 Apr 2006
Nature

Volume: 440, P: 1194-1198
Analysis of the DNA sequence and duplication history of human chromosome 15

An analysis of human chromosome 15 — which is altered in Prader-Willi and Angelman syndromes — reveals that it resembles a hall of mirrors, as it contains a number of sequence duplications throughout its length. The evolutionary events that may have led to the high number of duplications was also reconstructed.

Michael C. Zody
Manuel Garber
Chad Nusbaum
Research30 Mar 2006
Nature

Volume: 440, P: 671-675
The evolutionary history of lethal metastatic prostate cancer

The subclonal composition of human prostate tumours and their metastases has been mapped by whole-genome sequencing, thus establishing the evolutionary trees behind the development and spread of these cancers; an important observation was that metastases could be re-seeded multiple times, and spread from one tumour to another was frequently seen.

Gunes Gundem
Peter Van Loo
G. Steven Bova
Research01 Apr 2015
Nature

Volume: 520, P: 353-357
Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

Alzheimer disease (AD) and related dementias share numerous mechanistic and epidemiological similarities with type 2 diabetes mellitus (T2DM). However, whether these associations result from synergistic interactions between the disorders is unclear. This Review summarizes our current knowledge regarding insulin signalling and resistance in the brain and discusses current evidence concerning neurological impairment in T2DM and insulin resistance in AD.

Steven E. Arnold
Zoe Arvanitakis
David M. Nathan
Reviews29 Jan 2018
Nature Reviews Neurology

Volume: 14, P: 168-181
Continuous monitoring of physiological data using the patient vital status fusion score in septic critical care patients

Philipp L. S. Ohland
Thomas Jack
Steven R. Talbot
ResearchOpen Access26 Mar 2024
Scientific Reports

Volume: 14, P: 1-11
The multidisciplinary management of rectal cancer

Rectal cancer treatment has evolved towards a multidisciplinary approach to disease management. This Review examines the essential components of rectal cancer management through a multidisciplinary team, with a focus on the effect of this approach and the elements used for staging and developing the treatment plan.

Deborah S. Keller
Mariana Berho
Manish Chand
Reviews12 Mar 2020
Nature Reviews Gastroenterology & Hepatology

Volume: 17, P: 414-429
The finished DNA sequence of human chromosome 12

An analysis of the finished sequence of human chromosome 12 representing 4.5% of the human genome determines that chromosome 12 hosts a number of genes mutated in specific cancers, as well as movement disorders and potentially Alzheimer's disease.

Steven E. Scherer
Donna M. Muzny
Richard A. Gibbs
Research16 Mar 2006
Nature

Volume: 440, P: 346-351
Robustness of a multivariate composite score when evaluating distress of animal models for gastrointestinal diseases

Steven R. Talbot
Simone Kumstel
Dietmar Zechner
ResearchOpen Access14 Feb 2023
Scientific Reports

Volume: 13, P: 1-14
A model-specific simplification of the Mouse Grimace Scale based on the pain response of intraperitoneal CCl₄ injections

Lisa Ernst
Stefan Bruch
Steven R. Talbot
ResearchOpen Access28 Jun 2022
Scientific Reports

Volume: 12, P: 1-10
Body weight algorithm predicts humane endpoint in an intracranial rat glioma model

Simeon O. A. Helgers
Steven R. Talbot
Kerstin Schwabe
ResearchOpen Access02 Jun 2020
Scientific Reports

Volume: 10, P: 1-10
Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Research10 Jan 2022
Nature Medicine

Volume: 28, P: 53-58
Refining pain management in mice by comparing multimodal analgesia and NSAID monotherapy for neurosurgical procedures

Anna Munk
Vanessa Philippi
Heidrun Potschka
ResearchOpen Access12 Aug 2024
Scientific Reports

Volume: 14, P: 1-17
AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Abraham Heifets
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-16
Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Amendments and CorrectionsOpen Access12 Jan 2022
Nature Medicine

Volume: 28, P: 212
Experimenter familiarization is a crucial prerequisite for assessing behavioral outcomes and reduces stress in mice not only under chronic pain conditions

Daniel Segelcke
Steven R. Talbot
Anke Tappe-Theodor
ResearchOpen Access09 Feb 2023
Scientific Reports

Volume: 13, P: 1-14
A pro B cell population forms the apex of the leukemic hierarchy in Hoxa9/Meis1-dependent AML

Anna Lieske
Eric Agyeman-Duah
Tobias Maetzig
ResearchOpen Access14 Dec 2022
Leukemia

Volume: 37, P: 79-90
Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays

Olivier A. Pierrat
Manjuan Liu
Rob L. M. van Montfort
ResearchOpen Access03 Nov 2022
Scientific Reports

Volume: 12, P: 1-15
Whole body physiology model to simulate respiratory depression of fentanyl and associated naloxone reversal

Baird et al model opioid overdose and naloxone administration in a whole-body physiology model. The derived total naloxone rescue doses obtained are much higher than the current suggested guidelines.

Austin Baird
Steven A. White
Erika K. Bisgaard
ResearchOpen Access12 Jun 2024
Communications Medicine

Volume: 4, P: 1-14

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