The origin of Barrett oesophagus has been debated for many years, but no consensus has been reached. In this Perspectives article, Stuart McDonald and colleagues look at the Barrett lesion itself: at its phenotype, its complexity, its clonal architecture and its stem cell organization. They conclude that current evidence most strongly supports an origin from stem cells in the cardia.
- Stuart A. C. McDonald
- Danielle Lavery
- Marnix Jansen
