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Microporous materials such as zeolites are widely used in separation and catalytic applications. A thermally stable family of zeolites with chiral and achiral structures built from the same layer is now reported.

Galenza et al. show that basal stem cell progeny seamlessly integrate into a physiologically active barrier epithelium by gestating their future apical surface in a sheltering niche created by a transient occluding junction.

The authors identify two coexisting incommensurate charge density waves whose interplay leads to joint commensuration and a long-period moiré structure.

Thermal lepton pairs are ideal probes for the temperature of quark-gluon plasma. Here, the STAR Collaboration uses thermal electron-positron pair production to measure quark-gluon plasma average temperature at different stages of the evolution.

Anti-cancer drugs could independently promote TB progression. Here, the authors show using mouse models, that anti-cancer drug treatments could induce delayed Mtb-specific T cell responses, followed by G-CSF dependent neutrophil manifestation in the lungs, leading to TB exacerbation.

The stability of polymer electrolyte membrane fuel cells is limited by the degradation of the cathode catalyst during repetitive start-up/shut-down events — a parasitic oxygen reduction reaction on the anode causes an instantaneous potential jump at the cathode. The issue is now addressed by selectively suppressing the oxygen reduction reaction on the anode by exploiting the metal–insulator transition behaviour of Pt/H_xWO₃ catalysts.

The neural circuits that transmit cool signals remain not fully understood. Here, authors identify a spinal circuit in mice that transmits cool sensations from the skin to the brain, revealing a dedicated neural pathway for detecting innocuous cool temperatures.

Opposing forces generated by exopolysaccharide trail binding versus type IV pilus retraction generate a high cyclic diGMP–high cyclic AMP state in Pseudomonas aeruginosa that promotes social motility.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

CAR T cell manufacturing faces significant challenges that impact cell quality and in vivo efficacy. This necessitates reliable cellular characterization methods. Here the authors present a real-time, label-free, microfluidic method that profiles cellular biophysical properties and correlates them to activation state and CAR T potency, facilitating the rapid phenotypic cell assessment during production.

The insertion of thin layers of cobalt can stabilize β-tungsten under back-end-of-line thermal constraints, allowing a 64-kb spin–orbit torque magnetic random-access memory to be fabricated that offers a spin–orbit torque switching of 1 ns, data retention of more than 10 years and a tunnelling magnetoresistance of 146%.

Here the authors demonstrate functionality for on-chip optical communications via reconfigurable exciton-plasmon interconversion in 200 nm-diameter silver nanowires overlapping onto two-dimensional transition metal dichalcogenide transistors.

A geological, petrographic and geochemical survey of distinctive mudstone and conglomerate outcrops of the Bright Angel formation on Mars reveals textures, chemical and mineral characteristics, and organic signatures that warrant consideration as potential biosignatures.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Drop impact on a liquid surface leads to the formation of vortex rings, but this process is still poorly understood due to the lack of effective experimental characterization. Here, Leeet al. visualize the process using ultrafast X-ray phase-contrast imaging and follow the dynamics of vortex rings.

Glycogenin initiates glycogen synthesis, but its two human isoforms may do more than expected. Here, Weng et al. reveal that GYG2, despite low enzyme activity, drives glycogen particle assembly, uncovering a new layer of metabolic control.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

Although synthesis of high-quality MoS₂ has been demonstrated, growth of monolayer MoS₂at controlled locations is highly desirable for applications. Here, the authors introduce a method where patterned seeds of molybdenum source material are used to grow isolated flakes at predetermined locations.

During spontaneous thought, ideas including memories and imagined futures flow from one to another. This study shows that the brain’s default and control networks respond to these transitions and shape the variability and stability of thoughts.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

A bubble at an air–liquid interface can form a liquid jet upon bursting, spraying aerosol droplets into the air. Leeet al. show that jetting is analogous to pinching-off in liquid coalescence, which may be useful in applications that prevent jet formation and in the improved incorporation of aerosols in climate models.

Light trapped in the active polymeric layer limits the total efficiency of polymer light-emitting diodes. Here, Lee et al.get round this bottleneck by enhancing light extraction in waveguide optical modes via ripple-shaped nanostructures that spontaneously form on ZnO electrode surfaces.

Interactions between alveolar epithelial cells and macrophages shape lung development and function. Here Kang et al. develop alveolar assembloids by co-culturing alveolar organoids with macrophages providing a platform to model lung diseases.

While the organelle genome is commonly considered to be a single circular DNA molecule, extensive variation exists. Here, the authors report multipartite minicircular genomes in red algae and indicate an origin driven by recombination due to loss of DNA replication, recombination, and repair genes.

Exome sequencing of 851 trios from more than 2,500 individuals finds 187 genes with de novo mutations that contribute to meningomyelocele (spina bifida) and highlights critical pathways required for neural tube closure.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

Oxide ceramic electrolytes for Li-metal batteries often require high-temperature processing, which can compromise material reliability. Here, the authors present a sintering-free approach to synthesize disorder-driven garnet-type solid electrolytes, achieving performance comparable to traditional sintered materials.

Photolithography is an established microfabrication technique but commonly uses costly shortwavelength light sources to achieve high resolution. Here the authors use metal patterns embedded in a flexible elastomer photomask with mechanical robustness for generation of subdiffraction patterns as a cost effective near-field optical printing approach.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

Dietary n-6 PUFAs enhance adipose tissue expandability through the PPARγ–LPCAT3 membrane remodelling axis.

Determining whether somatosensory neurons are involved in internal or external sensing remains a challenge. Here, the authors show that analyzing connectivity is a powerful approach to identify putative neural functions of somatosensory neurons in the fly.

Acquiring subcellular-level three-dimensional (3D) tissue structures efficiently without damaging the tissue remains challenging in histopathology. Here, the authors integrate holotomography with deep learning to generate 3D virtual H&E staining images from label-free thick cancer tissues, and apply this approach to colon and gastric cancer samples.

Mapping enhancer-target gene pairs with single-cell multimodal data is challenged by the data’s unique characteristics and computational demands. Here, the authors propose scMultiMap, a statistical method with high statistical power and computational efficiency for inferring their associations.

Immunotherapy has yet to demonstrate efficacy for patients with glioblastoma. Here, the authors employ human single-cell RNA-seq, spatial transcriptomics, and a preclinical mouse model to show that glioblastoma cell-derived synaptogenic factor Thrombospondin-1 promotes neuronal circuit remodeling and regional immunosuppression, highlighting a potential therapeutic target.

The mechanical testing of thin films is non-trivial, due to their very fine dimensions. Kim et al. use the inherent surface tension of water as a platform for the frictionless tensile testing of gold films, with a thickness as fine as 55 nm.

Fabrication of complex two-dimensional patterns is now possible using ‘rails’ as a guiding mechanism for the self-assembly of microstructures within fluidic channels. The method is efficient, and heterogeneous systems, for example patterns of different living cells for tissue engineering, can be made with high precision.

Traditional non-volatile memories suffer from poor scalability in the vertical direction due to the use of a bulky oxide layer. Here, the authors develop a tunnelling random access memory using a vertical heterostructure composed of atomically thin molybdenum disulfide, boron nitride and graphene.