Identifying molecular regulators of immune aging is necessary to improve the response to infections and vaccine efficacy in aged hosts. Here, by exploring the age-related alterations of immune cells transcriptome comparing old and young mice, the authors identify the GTPase-protein, Rab8a, as regulator of dendritic cells (DC) in the context of immune aging.
- Sudhakar Singh
- Azeez Tehseen
- Sharvan Sehrawat