Nature Search

miR-296 regulation of a cell polarity–cell plasticity module controls tumor progression

V Vaira
A Faversani
S Bosari
Research06 Jun 2011
Oncogene

Volume: 31, P: 27-38
A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities

Drug synergies impact the efficacy of combination therapies but are difficult to identify. Here Narayan et al. describe the drug atlas, a method to predict effective drug combinations from common exclusive drug effects providing a resource for exploring and understanding effective drug combinations.

Ravi S. Narayan
Piet Molenaar
Bart A. Westerman
ResearchOpen Access10 Jun 2020
Nature Communications

Volume: 11, P: 1-14
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Resistance to first line treatment is a major hurdle in cancer treatment, that can be overcome with drug combinations. Here, the authors provide a large drug combination screen across cancer cell lines to benchmark crowdsourced methods and to computationally predict drug synergies.

Michael P. Menden
Dennis Wang
Julio Saez-Rodriguez
ResearchOpen Access17 Jun 2019
Nature Communications

Volume: 10, P: 1-17
Functional multiplex reporter assay using tagged Gaussia luciferase

Sjoerd van Rijn
Jonas Nilsson
Thomas Würdinger
ResearchOpen Access10 Jan 2013
Scientific Reports

Volume: 3, P: 1-5
Has botulinum toxin type A a place in the treatment of spasticity in spinal cord injury patients?

A T Al-Khodairy
C Gobelet
A B Rossier
Research04 Dec 1998
Spinal Cord

Volume: 36, P: 854-858
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

Human glioblastoma cells release microvesicles containing a diverse set of proteins, miRNAs and mRNAs, which can be taken up by normal host cells that translate the mRNA. Glioma-derived microvesicles carrying the specific tumour markers EGFRvIII and miRNA-21 promote cell proliferation and may serve as a diagnostic tool.

Johan Skog
Tom Würdinger
Xandra O. Breakefield
Research16 Nov 2008
Nature Cell Biology

Volume: 10, P: 1470-1476
Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16

M Aghi
T Visted
E A Chiocca
Research17 Mar 2008
Oncogene

Volume: 27, P: 4249-4254
Tumor-educated platelet blood tests for Non-Small Cell Lung Cancer detection and management

Mafalda Antunes-Ferreira
Silvia D’Ambrosi
Thomas Wurdinger
ResearchOpen Access08 Jun 2023
Scientific Reports

Volume: 13, P: 1-12
RNA sequencing and swarm intelligence–enhanced classification algorithm development for blood-based disease diagnostics using spliced blood platelet RNA

The particle-swarm optimization–enhanced thromboSeq pipeline enables RNA sequencing and cancer classification from blood platelet RNA, using self-learning and swarm intelligence–enhanced bioinformatics algorithms.

Myron G. Best
Sjors G. J. G. In ’t Veld
Thomas Wurdinger
Protocols20 Mar 2019
Nature Protocols

Volume: 14, P: 1206-1234
Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis

Lotte Hiddingh
Rajiv S. Raktoe
Thomas Wurdinger
ResearchOpen Access11 Jun 2014
Scientific Reports

Volume: 4, P: 1-10
MicroRNA-296-5p increases proliferation in gastric cancer through repression of Caudal-related homeobox 1

T Li
Y Y Lu
D M Fan
Research28 Jan 2013
Oncogene

Volume: 33, P: 783-793
Transcriptomic landscape of blood platelets in healthy donors

Anna Supernat
Marta Popęda
Anna J. Żaczek
ResearchOpen Access03 Aug 2021
Scientific Reports

Volume: 11, P: 1-10
Non-invasively measured brain activity and radiological progression in diffuse glioma

T. Numan
S. D. Kulik
L. Douw
ResearchOpen Access23 Sept 2021
Scientific Reports

Volume: 11, P: 1-10
Impact of Escherichia coli K12 and O18:K1 on human platelets: Differential effects on platelet activation, RNAs and proteins

A. V. Fejes
M. G. Best
C. Mannhalter
ResearchOpen Access01 Nov 2018
Scientific Reports

Volume: 8, P: 1-13
Targeting non-human coronaviruses to human cancer cells using a bispecific single-chain antibody

T Würdinger
M H Verheije
W R Gerritsen
Research21 Apr 2005
Gene Therapy

Volume: 12, P: 1394-1404
Suicidal gene therapy in an NF-κB-controlled tumor environment as monitored by a secreted blood reporter

C E Badr
J M Niers
B A Tannous
Research09 Dec 2010
Gene Therapy

Volume: 18, P: 445-451
Conditionally replicative adenovirus expressing a targeting adapter molecule exhibits enhanced oncolytic potency on CAR-deficient tumors

V W van Beusechem
D C J Mastenbroek
W R Gerritsen
Research06 Oct 2003
Gene Therapy

Volume: 10, P: 1982-1991
Antibody-mediated targeting of viral vectors to the Fc receptor expressed on acute myeloid leukemia cells

T Würdinger
M H Verheije
P J M Rottier
Correspondence12 Oct 2006
Leukemia

Volume: 20, P: 2182-2184
Molecular therapy in the microRNA era

T Wurdinger
F F Costa
Reviews26 Dec 2006
The Pharmacogenomics Journal

Volume: 7, P: 297-304

Search

miR-296 regulation of a cell polarity–cell plasticity module controls tumor progression

A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Functional multiplex reporter assay using tagged Gaussia luciferase

Has botulinum toxin type A a place in the treatment of spasticity in spinal cord injury patients?

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16

Tumor-educated platelet blood tests for Non-Small Cell Lung Cancer detection and management

RNA sequencing and swarm intelligence–enhanced classification algorithm development for blood-based disease diagnostics using spliced blood platelet RNA

Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis

MicroRNA-296-5p increases proliferation in gastric cancer through repression of Caudal-related homeobox 1

Transcriptomic landscape of blood platelets in healthy donors

Non-invasively measured brain activity and radiological progression in diffuse glioma

Impact of Escherichia coli K12 and O18:K1 on human platelets: Differential effects on platelet activation, RNAs and proteins

Targeting non-human coronaviruses to human cancer cells using a bispecific single-chain antibody

Suicidal gene therapy in an NF-κB-controlled tumor environment as monitored by a secreted blood reporter

Conditionally replicative adenovirus expressing a targeting adapter molecule exhibits enhanced oncolytic potency on CAR-deficient tumors

Antibody-mediated targeting of viral vectors to the Fc receptor expressed on acute myeloid leukemia cells

Molecular therapy in the microRNA era

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