Numerous studies have identified associations between gene polymorphisms and altered drug pharmacokinetics, particularly of immunosuppressive drugs used in solid organ transplantation. In this Review, Teun van Gelder and colleagues examine data supporting the ability of pharmacogenetic information to predict the pharmacokinetics or pharmacodynamics of immunosuppressive drugs, and discuss the potential impact of these data on clinical practice, with a focus on studies performed in renal transplant patients.
- Teun van Gelder
- Ron H. van Schaik
- Dennis A. Hesselink
