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Showing 1–50 of 746 results

Advanced filters: Author: Takashi Nakamura Clear advanced filters

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Whole exome sequencing in Japanese spinocerebellar ataxia identifies novel variants

Tomoaki Watanabe
Kodai Kume
Hideshi Kawakami
ResearchOpen Access12 Sept 2025
Journal of Human Genetics

P: 1-5
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
Jets in supernova 1987A?

Tsvi PIRAN
TAKASHI NAKAMURA
Research05 Nov 1987
Nature

Volume: 330, P: 28
Dilute-Solution Properties of Polystyrene Polymacromonomer Having Side Chains of over 100 Monomeric Units

Manabu Sugiyama
Yo Nakamura
Takashi Norisuye
Research11 Dec 2007
Polymer Journal

Volume: 40, P: 109-115
Predictors of poor outcomes after posterior decompression surgery in patients with degenerative cervical myelopathy

Satoshi Suzuki
Narihito Nagoshi
Junichi Yamane
Research04 Sept 2025
Spinal Cord

Volume: 63, P: 538-543
A novel superior factor widely controlling the rice grain quality

Kao-Chih She
Hiroaki Kusano
Hiroaki Shimada
ResearchOpen Access26 May 2009
Nature Precedings

P: 1
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

Takashi Nagasawa
Seiichi Hirota
Tadamitsu Kishimoto
Research15 Aug 1996
Nature

Volume: 382, P: 635-638
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Essential roles of the Fas ligand in the development of hepatitis

Toru Kondo
Takashi Suda
Shigekazu Nagata
Research01 Apr 1997
Nature Medicine

Volume: 3, P: 409-413
Intestinal CD4⁻CD8αβ⁻TCRαβ⁺ T cells function as tolerogenic antigen presenting cells in mice

The intestinal mucosa presents a complex immune environment requiring a fine balance of immune activity against pathogenic, benign or self antigens. Here the authors show that gut CD4⁻CD8αβ⁻TCRαβ⁺ T (double-negative T/DNT) cells express MHC-II, serve as antigen-presenting cells, and tolerize gut CD4 T cells to help maintain gut immune homeostasis.

Yasuhiro Nemoto
Ryo Morikawa
Ulrich H. von Andrian
ResearchOpen Access01 Aug 2025
Nature Communications

Volume: 16, P: 1-20
High proportion of missense mutations of the BRCA1 and BRCA2 genes in Japanese breast cancer families

Toyomasa Katagiri
Fujio Kasumi
Y. Miki
Research01 Feb 1998
Journal of Human Genetics

Volume: 43, P: 42-48
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
The uvrD gene of E. coli encodes a DNA-dependent ATPase

Kenji Oeda
Takashi Horiuchi
Mutsuo Sekiguchi
Research01 Jul 1982
Nature

Volume: 298, P: 98-100
Detailed deletion mapping suggests the involvement of a tumor suppressor gene at 17p13.3, distal to p53, in the pathogenesis of lung cancers

Hiroyuki Konishi
Takao Takahashi
Takashi Takahashi
Research21 Oct 1998
Oncogene

Volume: 17, P: 2095-2100
Author Correction: Immune evasion through mitochondrial transfer in the tumour microenvironment

Hideki Ikeda
Katsushige Kawase
Yosuke Togashi
Amendments and CorrectionsOpen Access25 Jul 2025
Nature

Volume: 644, P: E33
Backbone Stiffness of Comb-Branched Polymers

Yo Nakamura
Takashi Norisuye
Research01 Nov 2001
Polymer Journal

Volume: 33, P: 874-878
Second and Third Virial Coefficients for Polyisobutylene in Heptane, an Intermediate Solvent

Kazutomo Akasaka
Yo Nakamura
Akio Teramoto
Research01 Dec 1994
Polymer Journal

Volume: 26, P: 1387-1395
Small-Angle X-Ray Scattering from Polystyrene Polymacromonomers in Cyclohexane

Keiji Amitani
Ken Terao
Takashi Norisuye
Research19 Apr 2005
Polymer Journal

Volume: 37, P: 324-331
Immune evasion through mitochondrial transfer in the tumour microenvironment

Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

Hideki Ikeda
Katsushige Kawase
Yosuke Togashi
ResearchOpen Access22 Jan 2025
Nature

Volume: 638, P: 225-236
Benidipine Attenuates Glomerular Hypertension and Reduces Albuminuria in Patients with Metabolic Syndrome

Takashi Uzu
Masataka Nishimura
Genjiro Kimura
Research01 Feb 2007
Hypertension Research

Volume: 30, P: 161-165
Molecular recognition by multiple metal coordination inside wavy-stacked macrocycles

Synergistic use of coordination bonds that are strong and reversible realizes unique molecular recognition in artificial systems. Here, the authors show that a zinc-based metallomacrocyle can bind dicarboxylic acids of suitable length at specific metal sites by shape deformation and dimerization.

Takashi Nakamura
Yuya Kaneko
Tatsuya Nabeshima
ResearchOpen Access25 Jul 2017
Nature Communications

Volume: 8, P: 1-7
Roles of elements V and N in tetragonally distorted Fe-Co-V-N films

Takashi Hasegawa
Chihiro Murakami
Haruki Yamane
ResearchOpen Access05 Aug 2025
Scientific Reports

Volume: 15, P: 1-8
Podocyte-specific deletion of mechanochannel Piezo1 exacerbates proteinuria and podocyte injury in mouse hypertensive nephropathy

We created podocyte-specific Piezo1 KO mice, and hypertension was induced by angiotensin II and a high-salt diet. Hypertension-evoked proteinuria and podocyte injury were exaggerated in the KO mice. They were ameliorated by anti-hypertensive drugs and Rho kinase inhibitor, suggesting protective roles of Piezo1 and involvement of RhoA signaling.

Kaori Mikami
Takashi Nagase
Miki Nagase
Research02 Oct 2025
Hypertension Research

P: 1-17
Oligomer-based functions of mitochondrial porin

Cryo-EM structure of yeast Por1 hexamer reveals functions beyond metabolite and ion transport, including regulation of protein import via Tom22, maintaining lipid composition through scramblase activity, and regulating mitochondrial DNA retention and release.

Hironori Takeda
Saori Shinoda
Toshiya Endo
ResearchOpen Access25 Jul 2025
Nature Communications

Volume: 16, P: 1-15
Preparation and Characterization of Fluorine-containing Aromatic Condensation Polymers VIII. Aromatic Polyether and Copolyethers from 2,2-Bis(4-hydroxyphenyl)-1,1,1,3,3,3-hexafluoropropane, 2,2-Bis(4-hydroxyphenyl)propane, or both and Bis(4-fluorophenyl)phenylphosphine Oxide

Yasuo Saegusa
Takashi Koizumi
Research07 May 2005
Polymer Journal

Volume: 37, P: 399-403
Synthesis of Sequential Wholly Aromatic Polyketone Composed of 2,2′-Dimethoxybiphenylene Unit

Noriyuki Yonezawa
Asami Kameda
Katsuya Maeyama
Research16 Apr 2004
Polymer Journal

Volume: 36, P: 345-351
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Time evolution of piglet cerebral blood volume after resuscitation from hypoxic-ischemic insult

Manabu Machida
Tsutomu Mitsuie
Takashi Kusaka
ResearchOpen Access23 Jul 2025
Scientific Reports

Volume: 15, P: 1-8
Author Correction: Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication

Junichi Tanaka
Hidenobu Senpuku
Kenji Mishima
Amendments and Corrections21 Feb 2023
Nature Cell Biology

Volume: 25, P: 508
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Chondrule-like objects and Ca-Al-rich inclusions in Ryugu may potentially be the oldest Solar System materials

Chondrule-like objects and CAIs in the Ryugu samples are early generations of chondrules and possibly oldest solids in the Solar System. They were transported from the inner solar nebula to the formation location of the Ryugu original parent body.

Daisuke Nakashima
Tomoki Nakamura
Yuichi Tsuda
ResearchOpen Access16 Feb 2023
Nature Communications

Volume: 14, P: 1-9
Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25

Sox9 is an important transcription factor in the formation of cartilage chondrogenesis that occurs during skeletal development. Nakamuraet al.show that Sox9 interacts with Wwp2 and Med25 to form a complex and that loss of either protein in zebrafish results in altered palate chondrogenesis.

Yukio Nakamura
Koji Yamamoto
Haruhiko Akiyama
Research22 Mar 2011
Nature Communications

Volume: 2, P: 1-10
Tetralogy of Fallot, Pulmonary Valve Stenosis, Ventricular Septal Defect, and Hypertrophic Cardiomyopathy in WKY/NCrj Rats

Toshiro Kuribayashj
Kazutoshi Shimoo
Akinobu Nagaoka
Research01 May 1990
Pediatric Research

Volume: 27, P: 483-487
Hereditary Transmission of Tetralogy of Fallot, Cardiac Hypertrophy, and Anomalies of Great Vessels in WKY/NCrj Rats

Toshiro Kuribayashi
Masafumi Taniwaki
Yasuhiko Ibata
Research01 Sept 1991
Pediatric Research

Volume: 30, P: 227-230
Structural basis of transfer RNA processing by bacterial minimal RNase P

Transfer RNA maturation requires removal of extra sequences for proper function. Here, authors reveal how HARP, a protein-based enzyme, forms dodecamers that recognize specific tRNA features and process both 5′-leader and 3′-trailer sequences, demonstrating functional evolution.

Takamasa Teramoto
Takeshi Koyasu
Yoshimitsu Kakuta
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-15
Staphylococcus aureus ST764-SCCmecII high-risk clone in bloodstream infections revealed through national genomic surveillance integrating clinical data

Authors present results from a national surveillance in Japan that found MRSA strains causing bloodstream infections are predominantly from three clonal lineages. They also identified the emergence of highest 30-day-mortality MRSA clone ST764-SCCmecII and traced its evolutionary path.

Junzo Hisatsune
Shoko Kutsuno
Motoyuki Sugai
ResearchOpen Access19 Mar 2025
Nature Communications

Volume: 16, P: 1-14
Co-existence of cationic and chloride components in odorant-induced current of vertebrate olfactory receptor cells

Takashi Kurahashi
King-Wai Yau
Research06 May 1993
Nature

Volume: 363, P: 71-74
Fas ligand in human serum

Masato Tanaka
Takashi Suda
Shigekazu Nagata
Research01 Mar 1996
Nature Medicine

Volume: 2, P: 317-322
The Proportion of Individuals with Alcohol-Induced Hypertension among Total Hypertensives in a General Japanese Population: NIPPON DATA90

Koshi Nakamura
Tomonori Okamura
Hirotsugu Ueshima
Research01 Aug 2007
Hypertension Research

Volume: 30, P: 663-668
Solution Properties of Polymacromonomers Consisting of Polystyrene V. Effect of Side Chain Length on Chain Stiffness

Toshio Hokajo
Ken Terao
Takashi Norisuye
Research01 Jun 2001
Polymer Journal

Volume: 33, P: 481-485
A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis

Hiroyuki Nishimori
Takayuki Shiratsuchi
Takashi Tokino
Research30 Oct 1997
Oncogene

Volume: 15, P: 2145-2150
Synchrotron Small-Angle X-ray Scattering from Polystyrene Polymacromonomers in Toluene

Yo Nakamura
Manabu Sugiyama
Takashi Norisuye
Reviews28 Aug 2007
Polymer Journal

Volume: 39, P: 1098-1104
Excluded-Volume Effects in Star Polymer Solutions. Six-Arm Star Polystyrene in Benzene

Mitsuhiro Okumoto
Yoshimi Iwamoto
Takashi Norisuye
Research01 May 2000
Polymer Journal

Volume: 32, P: 422-427
Relationship between Metabolic Syndrome and Trp64Arg Polymorphism of the β3-Adrenergic Receptor Gene in a General Sample: The Shigaraki Study

Shinji Tamaki
Yasuyuki Nakamura
Hirotsugu Ueshima
Research01 Nov 2006
Hypertension Research

Volume: 29, P: 891-896
Induced-fit expansion and contraction of a self-assembled nanocube finely responding to neutral and anionic guests

Induced-fit binding, common in biological systems, is still relatively rare in artificial hosts. Here, the authors assemble a molecular cube from six gear-shaped faces, whose interdigitated design allows the cube to expand and contract in response to the size, shape, and charge of a guest molecule.

Yi-Yang Zhan
Tatsuo Kojima
Shuichi Hiraoka
ResearchOpen Access31 Oct 2018
Nature Communications

Volume: 9, P: 1-6
Worked human bones and the rise of urban society in the neolithic Liangzhu culture, East Asia

Junmei Sawada
Kazuhiro Uzawa
Shin’ichi Nakamura
ResearchOpen Access26 Aug 2025
Scientific Reports

Volume: 15, P: 1-14
Regulatory B cells drive immune evasion in the tumor microenvironment and are involved peritoneal metastasis in gastric cancer

Yuta Fujiwara
Jun Kinoshita
Noriyuki Inaki
ResearchOpen Access28 Jul 2025
Scientific Reports

Volume: 15, P: 1-13

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