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Showing 1–50 of 71 results

Advanced filters: Author: Takuya Nishimura Clear advanced filters

Eosinophils as a predictive marker of treatment-related adverse events in mRCC patients treated with first-line immune-checkpoint inhibitor combination therapy

Tatsushi Kawada
Satoshi Katayama
Motoo Araki
ResearchOpen Access25 Jul 2025
Scientific Reports

Volume: 15, P: 1-8
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
First trimester prenatal diagnosis of haemophilia a using factor VIII gene probe

Akira Yoshioka
Hiroyuki Naka
Hiromu Fukui
Research01 Jun 1989
Japanese journal of human genetics

Volume: 34, P: 135-141
Carrier detection in Japanese haemophilia a families using factor VIII gene probe (F8A) and the gene-linked ST 14-1 probe

Masato Nishino
Takuya Nishimura
Tomoaki Murotsu
Research01 Sept 1987
Japanese journal of human genetics

Volume: 32, P: 237-245
Nonsense mutation in factor VIII gene of a severe haemophiliac patient with anti-factor VIII antibody

Sadaaki Mikai
Takuya Nishimura
Tamotsu Hashimoto-Gotoh
Research01 Dec 1988
Japanese journal of human genetics

Volume: 33, P: 409-415
DNA typing of HLA in the patients with moyamoya disease

Takuya K. Inoue
Kiyonobu Ikezaki
Masashi Fukui
Research01 Dec 1997
Japanese Journal of Human Genetics

Volume: 42, P: 507-515
iTRAQ-based quantitative proteomics reveals reduced expression of KRT19, KRT7, and PSTDG in cutaneous specimens after kidney transplantation

Ichiro Tsuboi
Yosuke Mitsui
Motoo Araki
ResearchOpen Access26 Sept 2025
Scientific Reports

Volume: 15, P: 1-16
Chitosan-Coating of Cellulosic Materials Using an Aqueous Chitosan-CO₂ Solution

Yasuo Sakai
Koichi Hayano
Hisashi Yoshioka
Research01 Mar 2002
Polymer Journal

Volume: 34, P: 144-148
New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals

Shuji Hinuma
Yasushi Shintani
Masahiko Fujino
Research12 Sept 2000
Nature Cell Biology

Volume: 2, P: 703-708
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Evolutionary histories of breast cancer and related clones

By using phylogenetic analyses of multiple microdissected samples from both cancer and non-cancer lesions, unique evolutionary histories of breast cancers harbouring a common driver alteration are shown, providing new insight into how breast cancer evolves.

Tomomi Nishimura
Nobuyuki Kakiuchi
Seishi Ogawa
ResearchOpen Access26 Jul 2023
Nature

Volume: 620, P: 607-614
High-energy storage capacity of cellulose nanofiber supercapacitors using bound water

Mikio Fukuhara
Tomonori Yokotsuka
Toshiyuki Hashida
ResearchOpen Access03 Oct 2023
Scientific Reports

Volume: 13, P: 1-7
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Dynamic movement of the Golgi unit and its glycosylation enzyme zones

The structure of the Golgi and the localization of glycosylation enzymes remain largely elusive. Here, the authors use super-resolution microscopy to show that the Golgi is composed of small dynamic units which have rapidly moving zones of glycosylation enzymes.

Akihiro Harada
Masataka Kunii
Akihiko Nakano
ResearchOpen Access27 May 2024
Nature Communications

Volume: 15, P: 1-19
In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives

Several different genetic strategies have been reported for the modification of polyketide synthases but the highly repetitive modular structure makes this difficult. Here the authors report on an adapted Cas9 reaction and Gibson assembly to edit a target region of the polyketide synthases gene in vitro.

Kei Kudo
Takuya Hashimoto
Kazuo Shin-ya
ResearchOpen Access11 Aug 2020
Nature Communications

Volume: 11, P: 1-12
Prions prevent neuronal cell-line death

Chieko Kuwahara
Alice M. Takeuchi
Takashi Onodera
Research15 Jul 1999
Nature

Volume: 400, P: 225-226
Co-option and neofunctionalization of stomatal executors for defence against herbivores in Brassicales

The authors identified a transcriptional module, FAMA–WASABI MAKER (WSB), for the development of stomata and idioblast myrosin cells. They propose that the conserved and reduced FAMA–WSB module was co-opted before evolving to induce idioblast development.

Makoto Shirakawa
Tomoki Oguro
Toshiro Ito
ResearchOpen Access24 Feb 2025
Nature Plants

Volume: 11, P: 483-504
Non-canonical interplay between glutamatergic NMDA and dopamine receptors shapes synaptogenesis

Although functional interactions between receptors shape brain cell communication, their direct interaction remains elusive. Here, authors monitor the weak and transient interaction between NMDA and dopamine receptors, which tune synaptogenesis.

Nathan Bénac
G. Ezequiel Saraceno
Laurent Groc
ResearchOpen Access02 Jan 2024
Nature Communications

Volume: 15, P: 1-19
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor

Tetsuya Ohtaki
Yasushi Shintani
Masahiko Fujino
Research31 May 2001
Nature

Volume: 411, P: 613-617
Coseismic and postseismic slip of the 2011 magnitude-9 Tohoku-Oki earthquake

Shinzaburo Ozawa
Takuya Nishimura
Tetsuro Imakiire
Research15 Jun 2011
Nature

Volume: 475, P: 373-376
Myocardial TRPC6-mediated Zn²⁺ influx induces beneficial positive inotropy through β-adrenoceptors

Baroreflex control of cardiac contractility is essential to maintain cardiocirculatory homeostasis. Here, Oda et al show that α1 adrenoceptor-stimulated Zn2+ entry through TRPC6 channels boosts β adrenoceptor-dependent myocardial positive inotropy.

Sayaka Oda
Kazuhiro Nishiyama
Motohiro Nishida
ResearchOpen Access26 Oct 2022
Nature Communications

Volume: 13, P: 1-16
RFLPs of factor IX gene in Japanese haemophilia B families and gene deletion in two high-responder-inhibitor patients

Sadaaki Mikami
Masato Nishino
Hiromu Fukui
Research08 Jun 2005
Japanese journal of human genetics

Volume: 32, P: 21-31
Allosteric regulation accompanied by oligomeric state changes of Trypanosoma brucei GMP reductase through cystathionine-β-synthase domain

Trypanosoma brucei guanosine 5′-monophosphate reductase (TbGMPR) catalyses the conversion of GMP to inosine 5′-monophosphate and contains a cystathionine-β-synthase (CBS) domain. Here the authors combine X-ray crystallography and kinetic measurements and present the GMP-, GTP-bound and nucleotide-free TbGMPR structures and show that guanine and adenine nucleotides are allosteric regulators of TbGMPR that bind to the CBS domain.

Akira Imamura
Tetsuya Okada
Takashi Inui
ResearchOpen Access15 Apr 2020
Nature Communications

Volume: 11, P: 1-10
A deletion involving intron 13 and exon 14 of factor VIII gene in a haemophiliac with anti-factor VIII antibody

Sadaaki Mikami
Takuya Nishimura
Hiromu Fukui
Research01 Dec 1988
Japanese journal of human genetics

Volume: 33, P: 401-407
Anthracycline-containing regimens or taxane versus S-1 as first-line chemotherapy for metastatic breast cancer

Hirofumi Mukai
Yukari Uemura
Takuya Kawahara
Research03 Sept 2021
British Journal of Cancer

Volume: 125, P: 1217-1225
Macroscopically Anisotropic Structures Produced by Light-induced Solvothermal Assembly of Porphyrin Dimers

Yasuyuki Yamamoto
Yushi Nishimura
Takuya Iida
ResearchOpen Access23 Jul 2018
Scientific Reports

Volume: 8, P: 1-7
Mechanism of subsidence of the Northeast Japan forearc during the late period of a gigantic earthquake cycle

Ryohei Sasajima
Bunichiro Shibazaki
Yoshihiko Nakai
ResearchOpen Access05 Apr 2019
Scientific Reports

Volume: 9, P: 1-13
Comparison of radiation dermatitis between hypofractionated and conventionally fractionated postoperative radiotherapy: objective, longitudinal assessment of skin color

Hideya Yamazaki
Tadashi Takenaka
Kei Yamada
ResearchOpen Access17 Aug 2018
Scientific Reports

Volume: 8, P: 1-8
First demonstration of laser engagement of 1-Hz-injected flying pellets and neutron generation

Osamu Komeda
Yasuhiko Nishimura
Eisuke Miura
ResearchOpen Access06 Sept 2013
Scientific Reports

Volume: 3, P: 1-4
Submillimetre Network Formation by Light-induced Hybridization of Zeptomole-level DNA

Takuya Iida
Yushi Nishimura
Shiho Tokonami
ResearchOpen Access05 Dec 2016
Scientific Reports

Volume: 6, P: 1-9
Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease

Targeting gluten antigens presents a plausible therapy option for celiac disease. Here the authors generate and characterize a broadly neutralizing antibody recognizing more than 25 gluten peptide:HLA-DQ2.5 complexes, with structural analyses implicating its mode of interaction, and with mouse in vivo studies supporting its therapeutic feasibility.

Yuu Okura
Yuri Ikawa-Teranishi
Tomoyuki Igawa
ResearchOpen Access22 Dec 2023
Nature Communications

Volume: 14, P: 1-15
Impact of climate warming on the foraging behavior of northernmost distributed primates

Ema Nagahara
Ayaka Tsuchihashi
Masaki Takenaka
ResearchOpen Access25 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
Analysis of immunoglobulin transcripts and hypermutation following SHIV_AD8 infection and protein-plus-adjuvant immunization

HIV vaccine development will be facilitated by having animal models that are predictive for translation to humans. Here, the authors use two nonhuman primate models to compare the effects of natural infection and different adjuvants on antigen persistence, diversity and humoral immunity.

Joseph R. Francica
Zizhang Sheng
Robert A. Seder
ResearchOpen Access10 Apr 2015
Nature Communications

Volume: 6, P: 1-14
Longitudinal assessment of health-related quality of life in Japanese patients with advanced urothelial carcinoma receiving immune check point inhibitors

Makito Miyake
Nobutaka Nishimura
Kiyohide Fujimoto
ResearchOpen Access04 Oct 2024
Scientific Reports

Volume: 14, P: 1-11
Recapitulating the human segmentation clock with pluripotent stem cells

A system involving in vitro induction of presomitic mesoderm recapitulates oscillatory expression of core segmentation clock genes and travelling-wave-like gene expression, suggesting that this system can be used to study the human segmentation clock and provide insights into diseases associated with human axial skeletogenesis.

Mitsuhiro Matsuda
Yoshihiro Yamanaka
Cantas Alev
Research01 Apr 2020
Nature

Volume: 580, P: 124-129
In-vitro derived germinal centre B cells differentially generate memory B or plasma cells in vivo

In response to antigens, B cells proliferate and form germinal centres before differentiating into memory B cells or long-lived plasma cells. Here, a culture method is used to expand B cells in vitro, with the ability to shift the fate of the cells between memory B cells and long-lived plasma cells.

Takuya Nojima
Kei Haniuda
Daisuke Kitamura
Research06 Sept 2011
Nature Communications

Volume: 2, P: 1-11
Association of HLA-DRB1*04:05 allele with drug-induced interstitial lung disease in Japanese population

Takuya Imatoh
Atsuhito Ushiki
Masayuki Hanaoka
Research28 May 2020
The Pharmacogenomics Journal

Volume: 20, P: 823-830
Mechanistic insights into lethal hyper progressive disease induced by PD-L1 inhibitor in metastatic urothelial carcinoma

Kazuki Nishimura
Kiyoshi Takahara
Haruhito Azuma
ResearchOpen Access17 Sept 2024
npj Precision Oncology

Volume: 8, P: 1-8
Episodic transient deformation revealed by the analysis of multiple GNSS networks in the Noto Peninsula, central Japan

Takuya Nishimura
Yoshihiro Hiramatsu
Yusaku Ohta
ResearchOpen Access12 Jun 2023
Scientific Reports

Volume: 13, P: 1-11
Comparative analysis of necrotizing enterocolitis in preterm infants born in Japan and born to mothers of Japanese ethnicity in California

Satoshi Kusuda
Mihoko V. Bennett
Asao Yara
ResearchOpen Access22 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
Two distinct phenotypes in Snijders Blok-Campeau syndrome and characterization of the behavioral phenotype in a zebrafish model

Yumi Enomoto
Takashi Shiromizu
Kenji Kurosawa
Research23 Feb 2025
European Journal of Human Genetics

Volume: 33, P: 747-757
Association between serum lactate level during cardiopulmonary resuscitation and survival in adult out-of-hospital cardiac arrest: a multicenter cohort study

Norihiro Nishioka
Daisuke Kobayashi
Taku Iwami
ResearchOpen Access15 Jan 2021
Scientific Reports

Volume: 11, P: 1-9
Geriatric nutritional risk index and newly developed scoring system as prognosis prediction for unresectable hepatocellular carcinoma patients treated with lenvatinib

Hideko Ohama
Atsushi Hiraoka
Takashi Kumada
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-11
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Gradual reduction in rRNA transcription triggers p53 acetylation and apoptosis via MYBBP1A

Takuya Kumazawa
Kazuho Nishimura
Keiji Kimura
ResearchOpen Access05 Jun 2015
Scientific Reports

Volume: 5, P: 1-13
Pravastatin prevents colitis-associated carcinogenesis by reducing CX3CR1^high M2-like fibrocyte counts in the inflamed colon

Kensuke Hachiya
Masahiro Masuya
Naoyuki Katayama
ResearchOpen Access03 Oct 2024
Scientific Reports

Volume: 14, P: 1-15
Superelasticity of a photo-actuating chiral salicylideneamine crystal

Stimuli-responsive molecular organic crystals are of interest as actuating materials, but their mechanical responses are often poorly understood. Here, the authors study the photo-triggered phase transition of a chiral salicylideneamine crystal and uncover superelastic behaviour induced by light irradiation.

Takuya Taniguchi
Kazuki Ishizaki
Toru Asahi
ResearchOpen Access10 Jan 2022
Communications Chemistry

Volume: 5, P: 1-10

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