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Chronic cerebral hypoperfusion induces venous dysfunction via EPAS1 regulation in mice

How changes in brain blood vessels lead to a chronic reduction in blood flow and, consequently, to vascular dementia is poorly understood. Here, the authors show that venous endothelial dysfunction driven by EPAS1 promotes abnormal vascular remodeling and contributes to cognitive decline.

Vanessa Kristina Wazny
Aparna Mahadevan
Christine Cheung
ResearchOpen Access08 Jul 2025
Nature Communications

Volume: 16, P: 1-18
Development of spirulina for the manufacture and oral delivery of protein therapeutics

Spirulina is used to manufacture a therapeutic antibody against campylobacter.

Benjamin W. Jester
Hui Zhao
James Roberts
ResearchOpen Access21 Mar 2022
Nature Biotechnology

Volume: 40, P: 956-964
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Wnt signaling preserves progenitor cell multipotency during adipose tissue development

Single-cell transcriptomic analysis of human multipotent progenitor cells reveals that upon adipogenic stimulation, Wnt signaling regulates the generation of functional multipotent mesenchymal progenitors, named structural Wnt-regulated adipose tissue resident cells, which maintain the progenitor pool.

Zinger Yang Loureiro
Shannon Joyce
Silvia Corvera
ResearchOpen Access19 Jun 2023
Nature Metabolism

Volume: 5, P: 1014-1028
Adipose tissue as a linchpin of organismal ageing

Nguyen and Corvera review distinct changes that occur in adipose tissue during ageing, discuss potential mechanisms by which these changes impact whole-body metabolism, immunity and longevity, and highlight therapeutic opportunities.

Tammy T. Nguyen
Silvia Corvera
Reviews23 May 2024
Nature Metabolism

Volume: 6, P: 793-807
Author Correction: Development of spirulina for the manufacture and oral delivery of protein therapeutics

Benjamin W. Jester
Hui Zhao
James Roberts
Amendments and CorrectionsOpen Access19 Apr 2022
Nature Biotechnology

Volume: 40, P: 974
Exacerbation of Ventilation-Induced Lung Injury and Inflammation in Preterm Lambs by High-Dose Nanoparticles

Ishmael M. Inocencio
Robert J. Bischof
Timothy J. Moss
ResearchOpen Access31 Oct 2017
Scientific Reports

Volume: 7, P: 1-10
Factors affecting visual outcomes in patients with diabetic macular edema treated with ranibizumab

R Channa
R Sophie
Yasir Sepah
Research22 Nov 2013
Eye

Volume: 28, P: 269-278

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