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Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway

The water channel AQP2 mediates the concentration of urine in the kidney. Here Ando et al. show that Wnt5 promotes collecting duct permeability by regulating AQP2 expression and localization through activation of the calmodulin/calcineurin signalling pathway.

Fumiaki Ando
Eisei Sohara
Shinichi Uchida
ResearchOpen Access28 Nov 2016
Nature Communications

Volume: 7, P: 1-12
AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus

Patients suffering from congenital nephrogenic diabetes insipidus (NDI) fail to concentrate urine due to mutations in vasopressin type 2 receptor (V2R). Here Ando et al. show that agents disrupting the interaction between PKA and AKAPs restore aquaporin-2 activity downstream of V2R, offering a therapeutic approach for the treatment of NDI.

Fumiaki Ando
Shuichi Mori
Shinichi Uchida
ResearchOpen Access12 Apr 2018
Nature Communications

Volume: 9, P: 1-11
Gestational Length Affects a Change in the Transepithelial Voltage and the rNKCC2 Expression Pattern in the Ascending Thin Limb of Henle's Loop

Minako Nishino
Tetsuji Morimoto
Yoshiaki Kondo
Research01 Feb 2007
Pediatric Research

Volume: 61, P: 171-175
Novel mutations in five Japanese patients with 3-methylcrotonyl-CoA carboxylase deficiency

Mitsugu Uematsu
Osamu Sakamoto
Toshihiro Ohura
Research30 Oct 2007
Journal of Human Genetics

Volume: 52, P: 1040-1043
Hydrostatic pressure can induce apoptosis of the skin

Tien Minh Le
Naoki Morimoto
Kenji Kusumoto
ResearchOpen Access19 Oct 2020
Scientific Reports

Volume: 10, P: 1-16
Serum FABP5 concentration is a potential biomarker for residual risk of atherosclerosis in relation to cholesterol efflux from macrophages

Masato Furuhashi
Masatsune Ogura
Tetsuji Miura
ResearchOpen Access16 Mar 2017
Scientific Reports

Volume: 7, P: 1-10

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Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway

AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus

Gestational Length Affects a Change in the Transepithelial Voltage and the rNKCC2 Expression Pattern in the Ascending Thin Limb of Henle's Loop

Novel mutations in five Japanese patients with 3-methylcrotonyl-CoA carboxylase deficiency

Hydrostatic pressure can induce apoptosis of the skin

Serum FABP5 concentration is a potential biomarker for residual risk of atherosclerosis in relation to cholesterol efflux from macrophages

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