Nature Search

Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice

Thomas H Bugge
Leif R Lund
Jay L Degen
Research17 Jun 1998
Oncogene

Volume: 16, P: 3097-3104
A Correlation Between the Rates of Unimolecular Pyrolysis of Alkyl Halides in the Gaseous Phase and S _NI Rates in Solution

ALLAN MACCOLL
P. J. THOMAS
Research27 Aug 1955
Nature

Volume: 176, P: 392-393
Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V

Jisong Cui
K. Sue O'Shea
David Ginsburg
Research07 Nov 1996
Nature

Volume: 384, P: 66-68
Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome

Thomas Bugge and colleagues report that the matriptase protease initiates an epidermal kallikrein proteolytic cascade in mice lacking Spink5, which encodes the serine protease inhibitor LEKTI. Loss of matriptase rescued some features of excessive proteolytic degradation of corneodesmosomes and inflammatory activation in LEKTI-deficient mice, which are a model of human Netherton syndrome.

Katiuchia Uzzun Sales
Andrius Masedunskas
Thomas H Bugge
Research25 Jul 2010
Nature Genetics

Volume: 42, P: 676-683
Plasminogen promotes sarcoma growth and suppresses the accumulation of tumor-infiltrating macrophages

Alejandro Curino
David J Mitola
Thomas H Bugge
Research16 Dec 2002
Oncogene

Volume: 21, P: 8830-8842
Plasminogen and wound healing

John Rømer
Thomas H. Bugge
Keld Danø
Correspondence01 Jul 1996
Nature Medicine

Volume: 2, P: 725
Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle

Helen E. Thomas
Hendrik G. Stunnenberg
A. Francis Stewart
Research01 Apr 1993
Nature

Volume: 362, P: 471-475
Impaired wound healing in mice with a disrupted plasminogen gene

John Rømer
Thomas H. Bugge
Keld Danø
Research01 Mar 1996
Nature Medicine

Volume: 2, P: 287-292
Metastasis of transgenic breast cancer in plasminogen activator inhibitor-1 gene-deficient mice

Kasper Almholt
Boye S Nielsen
Morten Johnsen
Research10 Jul 2003
Oncogene

Volume: 22, P: 4389-4397
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Structural determinants of nuclear receptor assembly on DNA direct repeats

Fraydoon Rastinejad
Thomas Perlmann
Paul B. Sigler
Research18 May 1995
Nature

Volume: 375, P: 203-211
The Urokinase Plasminogen Activator Receptor–Associated Protein/Endo180 Is Coexpressed with Its Interaction Partners Urokinase Plasminogen Activator Receptor and Matrix Metalloprotease-13 during Osteogenesis

Lars Henning Engelholm
Boye Schnack Nielsen
Thomas Henrik Bugge
Research01 Oct 2001
Laboratory Investigation

Volume: 81, P: 1403-1414
A reinvestigation of non-disjunction resulting in 47, XXY males of paternal origin

N Simon Thomas
Andrew R Collins
Patricia A Jacobs
Research03 Oct 2000
European Journal of Human Genetics

Volume: 8, P: 805-808
Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid

Xiao-kun Zhang
Jürgen Lehmann
Magnus Pfahl
Research13 Aug 1992
Nature

Volume: 358, P: 587-591
Imaging specific cell-surface proteolytic activity in single living cells

John P Hobson
Shihui Liu
Thomas H Bugge
Research22 Mar 2006
Nature Methods

Volume: 3, P: 259-261
Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin

Shihui Liu
Vivien Redeye
Stephen H Leppla
Research15 May 2005
Nature Biotechnology

Volume: 23, P: 725-730
Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development

R Szabo
A Molinolo
T H Bugge
Research18 Sept 2006
Oncogene

Volume: 26, P: 1546-1556
Test of the universality of τ and μ lepton couplings in W-boson decays with the ATLAS detector

The ATLAS Collaboration reports a measurement of the ratio of the decay rates of W bosons to τ leptons and muons, in agreement with universal lepton couplings as postulated in the standard model of particle physics.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access05 Jul 2021
Nature Physics

Volume: 17, P: 813-818
c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase

R Szabo
A L Rasmussen
T H Bugge
Research10 Jan 2011
Oncogene

Volume: 30, P: 2003-2016
Observation of electroweak production of two jets and a Z-boson pair

The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access09 Feb 2023
Nature Physics

Volume: 19, P: 237-253
Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

Bin Zhou
Kate E. Sheffer
Majid Ezzati
ResearchOpen Access09 Nov 2023
Nature Medicine

Volume: 29, P: 2885-2901
Repositioning of the global epicentre of non-optimal cholesterol

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

Cristina Taddei
Bin Zhou
Majid Ezzati
ResearchOpen Access03 Jun 2020
Nature

Volume: 582, P: 73-77
A detailed map of Higgs boson interactions by the ATLAS experiment ten years after the discovery

Ten years after the discovery of the Higgs boson, the ATLAS experiment at CERN probes its kinematic properties with a significantly larger dataset from 2015–2018 and provides further insights on its interaction with other known particles.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access04 Jul 2022
Nature

Volume: 607, P: 52-59
Abnormal development of NG2⁺PDGFR-α⁺ neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse model

Hydrocephalus is a neurological disorder characterized by expansion of the ventricles. In a mouse model, the authors identified a role for neural progenitors and for platelet-derived growth factor signaling in the pathogenesis of neonatal hydrocephalus. Targeting this pathway reduced ventricular volume, pointing to a new therapeutic target for this condition.

Calvin S Carter
Timothy W Vogel
Val C Sheffield
Research18 Nov 2012
Nature Medicine

Volume: 18, P: 1797-1804
Profiling changes in keratinocyte gene expression during wound reepithelialization by laser capture microdissection combined with cDNA array analysis

Tanja X. Pedersen
Chichadnok Leethanakul
Thomas H. Bugge
Research Highlights01 Apr 2001
Nature Genetics

Volume: 27, P: 78
Search for charged-lepton-flavour violation in Z-boson decays with the ATLAS detector

The ATLAS experiment at the Large Hadron Collider reports a search for charged-lepton-flavour violation in decays of Z bosons into a τ lepton and an electron or muon of opposite charge.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access01 Jul 2021
Nature Physics

Volume: 17, P: 819-825
An anthrax toxin variant with an improved activity in tumor targeting

Alexander N. Wein
Diane E. Peters
Shihui Liu
ResearchOpen Access20 Nov 2015
Scientific Reports

Volume: 5, P: 1-8
Evidence for light-by-light scattering in heavy-ion collisions with the ATLAS detector at the LHC

Quantum electrodynamics predicts a rare process in which light is scattered by light. The ATLAS Collaboration reports signs of this elusive effect in the collisions of ultra-relativistic lead ions.

M. Aaboud
G. Aad
L. Zwalinski
ResearchOpen Access14 Aug 2017
Nature Physics

Volume: 13, P: 852-858
Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis

P Kosa
R Szabo
T H Bugge
Research05 Dec 2011
Oncogene

Volume: 31, P: 3679-3695
Measurement of the inelastic proton–proton cross-section at √s=7 TeV with the ATLAS detector

The measurement of the total cross-section of proton–proton collisions is of fundamental importance for particle physics. Here, the first measurement of the inelastic cross-section is presented for proton–proton collisions at an energy of 7 teraelectronvolts using the ATLAS detector at the Large Hadron Collider.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access06 Sept 2011
Nature Communications

Volume: 2, P: 1-14
Anthrax lethal factor cleaves regulatory subunits of phosphoinositide-3 kinase to contribute to toxin lethality

Cellular targets of anthrax lethal factor are identified to reveal the molecular basis of toxin-induced death.

Megan A. Mendenhall
Shihui Liu
Mahtab Moayeri
Research07 Sept 2020
Nature Microbiology

Volume: 5, P: 1464-1471
Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

Honor Bixby
James Bentham
Majid Ezzati
ResearchOpen Access08 May 2019
Nature

Volume: 569, P: 260-264
Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis

K U Sales
S Friis
T H Bugge
Research27 Jan 2014
Oncogene

Volume: 34, P: 346-356
Anthrax target in macrophages unveiled

Anthrax lethal toxin lyses macrophages derived from certain inbred mice but not others, forming the basis of a bioassay widely used in the development of antibodies and drugs to treat anthrax. A new study identifies two genes essential for this lysis, revealing potential links between toxin-induced proteolysis and cellular killing.

Thomas H Bugge
Stephen H Leppla
News & Views01 Feb 2006
Nature Genetics

Volume: 38, P: 137-138
Identification of the gene that, when mutated, causes the human obesity syndrome BBS4

Kirk Mykytyn
Terry Braun
Val C. Sheffield
Research01 Jun 2001
Nature Genetics

Volume: 28, P: 188-191
Evidence of functional interaction between NuMA-RARα and RXRα in an in vivo model of acute promyelocytic leukemia

M A Sukhai
M Thomas
S Kamel-Reid
Research14 Apr 2008
Oncogene

Volume: 27, P: 4666-4677
Author Correction: A detailed map of Higgs boson interactions by the ATLAS experiment ten years after the discovery

G. Aad
B. Abbott
L. Zwalinski
Amendments and CorrectionsOpen Access18 Oct 2023
Nature

Volume: 623, P: E5
Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis

Signe Z. Ingvarsen
Henrik Gårdsvoll
Niels Behrendt
ResearchOpen Access05 Nov 2020
Scientific Reports

Volume: 10, P: 1-16
Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis

Karin List
Christian C Haudenschild
Thomas H Bugge
Research24 May 2002
Oncogene

Volume: 21, P: 3765-3779
Laser capture microdissection-based in vivo genomic profiling of wound keratinocytes identifies similarities and differences to squamous cell carcinoma

Tanja Xenia Pedersen
Chidchanop Leethanakul
Thomas Henrik Bugge
Research17 Jun 2003
Oncogene

Volume: 22, P: 3964-3976
Matriptase promotes inflammatory cell accumulation and progression of established epidermal tumors

K U Sales
S Friis
T H Bugge
Research08 Dec 2014
Oncogene

Volume: 34, P: 4664-4672

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