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Elucidating molecularly stratified single agent, and combination, therapeutic strategies targeting MCL1 for lethal prostate cancer

Despite improving therapeutic options, the prognosis for patients with metastatic castration-resistance prostate cancer (mCRPC) remains poor. Here, the authors identify MCL1 copy number alterations as a prognostic and predictive biomarker, demonstrating its therapeutic potential as a drug target, either alone or in combination, in patients with mCRPC.

Juan M. Jiménez-Vacas
Daniel Westaby
Adam Sharp
ResearchOpen Access08 Oct 2025
Nature Communications

Volume: 16, P: 1-22
Preeclampsia risk prediction from prenatal cell-free DNA screening

Using 1,854 routinely collected clinical samples from early in pregnancy, with validation in an external cohort, low-coverage cfDNA sequence data identified distinctive features among those who developed preeclampsia.

Mohamed Adil
Teodora R. Kolarova
Raj Shree
ResearchOpen Access12 Feb 2025
Nature Medicine

Volume: 31, P: 1312-1318
Assessment of TROP2, CEACAM5 and DLL3 in metastatic prostate cancer: Expression landscape and molecular correlates

Azra Ajkunic
Erolcan Sayar
Michael C. Haffner
ResearchOpen Access17 May 2024
npj Precision Oncology

Volume: 8, P: 1-9

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