Nature Search

Regulation of telomerase activity by the p53 family member p73

M Beitzinger
C Oswald
T Stiewe
Research03 Oct 2005
Oncogene

Volume: 25, P: 813-826
Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations

A large-scale CRISPR-mediated deep mutational scanning approach is used to interrogate the function of mutations in the endogenous locus of TP53 mapping to the DNA-binding domain.

Julianne S. Funk
Maria Klimovich
Thorsten Stiewe
ResearchOpen Access07 Jan 2025
Nature Genetics

Volume: 57, P: 140-153
The p53 family in differentiation and tumorigenesis

Are members of the p53 family of transcription factors able to influence tumour development by regulating cellular differentiation?

Thorsten Stiewe
Reviews01 Feb 2007
Nature Reviews Cancer

Volume: 7, P: 165-167
KRAS and TP53 co-mutation predicts benefit of immune checkpoint blockade in lung adenocarcinoma

Jan Budczies
Eva Romanovsky
Albrecht Stenzinger
ResearchOpen Access12 Jun 2024
British Journal of Cancer

Volume: 131, P: 524-533
mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability

mTORC1 is a key mediator of drug resistance and also regulates autophagy. In this study, the authors demonstrate that cancer cells with acquired drug resistance exibit metabolic vulnerabilities mediated by high levels of mTORC1 and the consequent inhibition of autophagy.

Niklas Gremke
Pierfrancesco Polo
Thorsten Stiewe
ResearchOpen Access17 Sept 2020
Nature Communications

Volume: 11, P: 1-15
Detection of minimal residual disease in circulating cell-free DNA in acute myeloid leukemia

Charlotte Sommer
Hildegard I. D. Mack
Elisabeth K. M. Mack
ResearchOpen Access23 Sept 2025
Scientific Reports

Volume: 15, P: 1-12
A searchable atlas of pathogen-sensitive lncRNA networks in human macrophages

Long non-coding RNAs (lncRNA) are known immune regulators, yet a systemic understanding of their regulatory crosstalk is still elusive. Here the authors establish a platform integrating RNA-binding proteome analyses and protein interactomes to map the lncRNA target network in human primary macrophages to build a searchable atlas of lncRNA.

Nils Schmerer
Harshavardhan Janga
Leon N. Schulte
ResearchOpen Access21 May 2025
Nature Communications

Volume: 16, P: 1-17
CRISPR-Cas9–based target validation for p53-reactivating model compounds

CRISPR-Cas9 based target validation revealed that the sensitivity of the p53-reactivating compound RITA is independent of functional p53 and is reliant on the regulation of the DNA damage-activated Fanconi anemia pathway.

Michael Wanzel
Jonas B Vischedyk
Thorsten Stiewe
Research23 Nov 2015
Nature Chemical Biology

Volume: 12, P: 22-28
Monitoring the dynamics of clonal tumour evolution in vivo using secreted luciferases

Non-invasive monitoring of solid tumour growth in mice is difficult. In this study, the authors develop a system for monitoring the secretion of luciferase either from Gaussia princeps or Cypridina noctiluca in the blood of mice harbouring luciferase-labelled tumour cells, thus providing a system to monitor two different cell populations in vivo.

Joël P. Charles
Jeannette Fuchs
Thorsten Stiewe
ResearchOpen Access03 Jun 2014
Nature Communications

Volume: 5, P: 1-11
DARPin-induced reactivation of p53 in HPV-positive cells

The binding of a DARPin to p53 displaces the human papillomavirus (HPV) E6 protein and stabilizes p53 in HPV-infected cells. This interaction reactivates a p53-dependent transcriptional program, suggesting a potential new therapeutic strategy for treating HPV-induced cancers.

Philipp Münick
Alexander Strubel
Volker Dötsch
Research09 Jan 2025
Nature Structural & Molecular Biology

Volume: 32, P: 790-801
Role of the p53-homologue p73 in E2F1-induced apoptosis

Thorsten Stiewe
Brigitte M. Pützer
Research01 Dec 2000
Nature Genetics

Volume: 26, P: 464-469
LITESEC-T3SS - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution

The type III secretion system (T3SS) of bacteria can be used to inject cargo into eukaryotic cells but its lack of target specificity is a disadvantage. Here the authors place the T3SS under the regulation of light by engineering optogenetic switches into the dynamic cytosolic T3SS component SctQ.

Florian Lindner
Bailey Milne-Davies
Andreas Diepold
ResearchOpen Access13 May 2020
Nature Communications

Volume: 11, P: 1-13
The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes

Short-chain fatty acids (SCFAs) have immunomodulatory effects, but the underlying mechanisms are still unclear. Here the authors show that a SCFA, pentanoate, suppresses autoimmune inflammation in mouse models of colitis and multiple sclerosis via epigenetic modulation of immune cell metabolic and functional pathways.

Maik Luu
Sabine Pautz
Alexander Visekruna
ResearchOpen Access15 Feb 2019
Nature Communications

Volume: 10, P: 1-12
The H2A.Z and NuRD associated protein HMG20A controls early head and heart developmental transcription programs

How the histone variant H2A.Z controls cell fate remains unclear. Here, the authors reveal that the H2A.Z interacting partner HMG20A plays a key role in regulating transcription during early head and heart development.

Andreas Herchenröther
Stefanie Gossen
Sandra B. Hake
ResearchOpen Access28 Jan 2023
Nature Communications

Volume: 14, P: 1-20
SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells

Tight regulation of retrotransposons such as endogenous retroviruses (ERVs) is essential for genome and transcriptome integrity. Here, the authors show that the ATPase function of the chromatin remodeler SMARCAD1 facilitates the binding of KAP1 to ERVs and is required for their repression in embryonic stem cells.

Parysatis Sachs
Dong Ding
Jacqueline E. Mermoud
ResearchOpen Access22 Mar 2019
Nature Communications

Volume: 10, P: 1-16
The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic

In two mouse models of intestinal cancer, mutant p53 has an oncogenic effect in the distal gut but a tumour-suppressive effect in the proximal gut, and these opposing properties are determined by the gut microbiome.

Eliran Kadosh
Irit Snir-Alkalay
Yinon Ben-Neriah
Research29 Jul 2020
Nature

Volume: 586, P: 133-138
PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex

PWWP2A is a chromatin-binding transcriptional regulator that mediates mitosis-progression. Here, the authors provide evidence that PWWP2A directly interacts with H2A.Z nucleosomes, DNA and H3K36me3, binds to an MTA1-specific subcomplex of the NuRD complex (M1HR) and promotes changes to histone acetylation.

Stephanie Link
Ramona M. M. Spitzer
Sandra B. Hake
ResearchOpen Access16 Oct 2018
Nature Communications

Volume: 9, P: 1-16
Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes

Jan Dreute
Julia Stengel
M. Lienhard Schmitz
ResearchOpen Access23 Jun 2025
Cell Death & Differentiation

P: 1-18
Targeting PI3K inhibitor resistance in breast cancer with metabolic drugs

Niklas Gremke
Isabelle Besong
Thorsten Stiewe
ResearchOpen Access21 Mar 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-19
Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus

Wilhelm Bertrams
Katja Hönzke
Andreas C. Hocke
ResearchOpen Access29 Nov 2022
Scientific Reports

Volume: 12, P: 1-11
TP53: the unluckiest of genes?

Andreas C. Joerger
Thorsten Stiewe
Thierry Soussi
ReviewsOpen Access23 Oct 2024
Cell Death & Differentiation

Volume: 32, P: 219-224
p53 partial loss-of-function mutations sensitize to chemotherapy

Boris Klimovich
Nastasja Merle
Thorsten Stiewe
ResearchOpen Access14 Dec 2021
Oncogene

Volume: 41, P: 1011-1023
BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells

Bilal Alashkar Alhamwe
Viviane Ponath
Elke Pogge von Strandmann
ResearchOpen Access28 Jun 2024
Cellular & Molecular Immunology

Volume: 21, P: 918-931
miR-147b mediated suppression of DUSP8 promotes lung cancer progression

Kati Turkowski
Frederik Herzberg
Rajkumar Savai
ResearchOpen Access23 Feb 2024
Oncogene

Volume: 43, P: 1178-1189
Pericentromeric satellite lncRNAs are induced in cancer-associated fibroblasts and regulate their functions in lung tumorigenesis

Natella I. Enukashvily
Nikita V. Ponomartsev
Anna I. Brichkina
ResearchOpen Access12 Jan 2023
Cell Death & Disease

Volume: 14, P: 1-15
Homogenous TP53mut-associated tumor biology across mutation and cancer types revealed by transcriptome analysis

Eva Romanovsky
Klaus Kluck
Jan Budczies
ResearchOpen Access14 Apr 2023
Cell Death Discovery

Volume: 9, P: 1-14
IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

Dennis Das Gupta
Christoph Paul
Michael Lohoff
ResearchOpen Access22 Apr 2022
Cell Death & Differentiation

Volume: 29, P: 2163-2176
The p53 family inhibitor ΔNp73 interferes with multiple developmental programs

N Hüttinger-Kirchhof
H Cam
T Stiewe
Correspondence08 Dec 2005
Cell Death & Differentiation

Volume: 13, P: 174-177
Effects of YM155 on survivin levels and viability in neuroblastoma cells with acquired drug resistance

Yvonne Voges
Martin Michaelis
Jindrich Cinatl
ResearchOpen Access13 Oct 2016
Cell Death & Disease

Volume: 7, P: e2410

Search

Regulation of telomerase activity by the p53 family member p73

Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations

The p53 family in differentiation and tumorigenesis

KRAS and TP53 co-mutation predicts benefit of immune checkpoint blockade in lung adenocarcinoma

mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability

Detection of minimal residual disease in circulating cell-free DNA in acute myeloid leukemia

A searchable atlas of pathogen-sensitive lncRNA networks in human macrophages

CRISPR-Cas9–based target validation for p53-reactivating model compounds

Monitoring the dynamics of clonal tumour evolution in vivo using secreted luciferases

DARPin-induced reactivation of p53 in HPV-positive cells

Role of the p53-homologue p73 in E2F1-induced apoptosis

LITESEC-T3SS - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution

The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes

The H2A.Z and NuRD associated protein HMG20A controls early head and heart developmental transcription programs

SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells

The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic

PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex

Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes

Targeting PI3K inhibitor resistance in breast cancer with metabolic drugs

Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus

TP53: the unluckiest of genes?

p53 partial loss-of-function mutations sensitize to chemotherapy

BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells

miR-147b mediated suppression of DUSP8 promotes lung cancer progression

Pericentromeric satellite lncRNAs are induced in cancer-associated fibroblasts and regulate their functions in lung tumorigenesis

Homogenous TP53mut-associated tumor biology across mutation and cancer types revealed by transcriptome analysis

IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

The p53 family inhibitor ΔNp73 interferes with multiple developmental programs

Effects of YM155 on survivin levels and viability in neuroblastoma cells with acquired drug resistance

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