To maintain efficient force generation, myosins must couple the ATPase cycle with actin binding and lever movement, but the mechanism for this coupling and actin activation of myosin has remained elusive. Now, a conserved actin-binding loop is found to be responsible for activating the ATPase by acceleration of the lever swing, increasing the ratio of mechanically productive to futile actomyosin cycles.
- Boglárka H Várkuti
- Zhenhui Yang
- András Málnási-Csizmadia
