Nature Search

Revealing the genetic architectures underlying organ-specific aging based on proteomic data

This study leverages plasma proteomics from over 50,000 individuals to build organ-specific aging models and uncover underlying genetic mechanisms. It also investigates causal links between organ aging, diseases, and lifestyle, providing insights for promoting healthy longevity.

Ren-Jie Zhu
Yan Guo
Tie-Lin Yang
ResearchOpen Access11 Dec 2025
Nature Communications

Volume: 17, P: 1-14
Deoxygenative radical cross-coupling of C(sp³)−O/C(sp³)−H bonds promoted by hydrogen-bond interaction

Conventional methods for forming C(sp3)−C(sp3) bonds via radical-radical coupling pathways often suffer from poor selectivity, limiting their practicality in synthetic applications. Herein, the authors report a single electron transfer strategy that enables the cleavage of amine α-C − H bonds and heterobenzylic C − O bonds to form C(sp3)−C(sp3) bonds.

Yue Wang
Suping Zhang
Guoqin Xia
ResearchOpen Access08 Aug 2024
Nature Communications

Volume: 15, P: 1-8
Electric bias-induced reversible configuration of single and heteronuclear dual-atom catalysts on 1Tʹ-MoS₂

A dynamic Cu–Pt dual-atom catalyst supported on 1Tʹ-MoS₂ can be electrically switched between single- and dual-atom configurations, enabling on-demand control for alkyne semi-hydrogenation.

Jianhua Wu
Zhongxin Chen
Kian Ping Loh
Research19 May 2025
Nature Nanotechnology

Volume: 20, P: 1043-1051
Simplified radar architecture based on information metasurface

The authors present a simplified-architecture radar that uses information metasurfaces for direct generation and dechirp compression of radar signals in the RF domain, enabling full-chain reconfigurability without using extensive RF hardware and high-speed digitization.

Si Ran Wang
Zhan Ye Chen
Tie Jun Cui
ResearchOpen Access15 Jul 2025
Nature Communications

Volume: 16, P: 1-11
Structure and mechanism of vitamin-K-dependent γ-glutamyl carboxylase

Structural and cellular assays and molecular dynamics simulations reveal the mechanism of action of γ-glutamyl carboxylase, which involves cholesterol and vitamin K.

Rong Wang
Baozhi Chen
Xiaofeng Qi
Research29 Jan 2025
Nature

Volume: 639, P: 808-815
Mendelian randomization analyses support causal relationships between brain imaging-derived phenotypes and risk of psychiatric disorders

Guo et al. use two-sample Mendelian randomization analyses to reveal causal relationships between neuroimaging phenotypes and psychiatric disorders. This insight may be helpful in predicting psychiatric disorder risk at the neuroimaging level.

Jing Guo
Ke Yu
Tie-Lin Yang
Research10 Oct 2022
Nature Neuroscience

Volume: 25, P: 1519-1527
A filtering reconfigurable intelligent surface for interference-free wireless communications

A filtering reconfigurable intelligent surface is presented with sharp frequency-selecting and 2-bit phase-shifting properties, offering to advance the development of wireless communications with anti-interference and signal-manipulation abilities.

Jing Cheng Liang
Lei Zhang
Tie Jun Cui
ResearchOpen Access07 May 2024
Nature Communications

Volume: 15, P: 1-12
A transcription factor ZmGLK36 confers broad resistance to maize rough dwarf disease in cereal crops

A novel resistance gene against maize rough dwarf disease was identified, which confers broad resistance to the virus pathogen infecting multiple cereal crops by regulating jasmonic acid (JA) biosynthesis and JA-mediated defence response.

Zhennan Xu
Zhiqiang Zhou
Xinhai Li
Research14 Sept 2023
Nature Plants

Volume: 9, P: 1720-1733
Genomic insights into the formation of human populations in East Asia

Genome-wide data from 166 East Asian individuals dating to between 6000 bc and ad 1000 and from 46 present-day groups provide insights into the histories of mixture and migration of human populations in East Asia.

Chuan-Chao Wang
Hui-Yuan Yeh
David Reich
Research22 Feb 2021
Nature

Volume: 591, P: 413-419
Histidine kinase MHZ1/OsHK1 interacts with ethylene receptors to regulate root growth in rice

Ethylene regulates adaptive root growth during waterlogging in rice. Here, the authors identify MHZ1 (aka OsHK1), a histidine kinase that positively regulates the root ethylene response by interacting with the ethylene receptor ERS2 and promoting phosphorylation of the response regulator, OsRR21.

He Zhao
Kai-Xuan Duan
Jin-Song Zhang
ResearchOpen Access24 Jan 2020
Nature Communications

Volume: 11, P: 1-13
Manipulations of multi-frequency waves and signals via multi-partition asynchronous space-time-coding digital metasurface

The authors present a multi-partition asynchronous space-time-coding digital metasurface (ASTCM) to control multifrequency waves; they demonstrate its capabilities by sending eight pictures over distinct frequencies using this wireless transmitter. The proposed work shows potential in enhancing microwave systems with improved power efficiency and cost-effectiveness.

Si Ran Wang
Jun Yan Dai
Tie Jun Cui
ResearchOpen Access04 Sept 2023
Nature Communications

Volume: 14, P: 1-12
Rectifying disorder of extracellular matrix to suppress urethral stricture by protein nanofilm-controlled drug delivery from urinary catheter

Various anti-fibrotic drugs have been applied to urethral stricture by irrigation or submucosal injection, but their clinical feasibility and effectiveness are limited. Here, the authors design a protein-based nanofilm-controlled drug delivery system with anti-biofilm properties that can be assembled on a catheter.

Juanhua Tian
Delai Fu
Peng Yang
ResearchOpen Access17 May 2023
Nature Communications

Volume: 14, P: 1-17
A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase

The authors develop a Vitamin K-dependent apoptotic reporter cell line for large-scale screening of enzymes associated with Vitamin K-dependent carboxylation and identify ferroptosis suppressor protein 1 (FSP1) as responsible for warfarin-resistant vitamin K reduction.

Da-Yun Jin
Xuejie Chen
Jian-Ke Tie
ResearchOpen Access14 Feb 2023
Nature Communications

Volume: 14, P: 1-14
Role of PDGFRA⁺ cells and a CD55⁺ PDGFRA^Lo fraction in the gastric mesenchymal niche

Digestive epithelia self-renew or differentiate in response to mesenchymal cues. Manieri et al. characterize gastric corpus and antral mesenchyme separately and identify PDGFRA^Lo CD55⁺ cells as those selectively supporting epithelial growth in vitro.

Elisa Manieri
Guodong Tie
Ramesh A. Shivdasani
ResearchOpen Access02 Dec 2023
Nature Communications

Volume: 14, P: 1-18
Independent control of harmonic amplitudes and phases via a time-domain digital coding metasurface

Jun Yan Dai
Jie Zhao
Tie Jun Cui
ResearchOpen Access21 Nov 2018
Light: Science & Applications

Volume: 7, P: 1-10
The effects of inhibiting IRE1α on the viability of ovarian granulosa cells

Chao Li
Yong-Peng Tan
Xiao-Can Lei
ResearchOpen Access04 Jun 2025
Scientific Reports

Volume: 15, P: 1-10
Epidemiology, evolution and transmission of human metapneumovirus in Guangzhou China, 2013–2017

Lina Yi
Lirong Zou
Jie Wu
ResearchOpen Access01 Oct 2019
Scientific Reports

Volume: 9, P: 1-9
Broadband and Broad-Angle Low-Scattering Metasurface Based on Hybrid Optimization Algorithm

Ke Wang
Jie Zhao
Tie Jun Cui
ResearchOpen Access04 Aug 2014
Scientific Reports

Volume: 4, P: 1-6
Genomic Variants in NEURL, GJA1 and CUX2 Significantly Increase Genetic Susceptibility to Atrial Fibrillation

Pengxia Wang
Weixi Qin
Qing K. Wang
ResearchOpen Access19 Feb 2018
Scientific Reports

Volume: 8, P: 1-7
Association of human carboxypeptidase E exon5 gene polymorphisms with angiographical characteristics of coronary atherosclerosis in a Chinese population

Jie Wang
Yun Zhang
En-zhi Jia
Research01 Jun 2008
Acta Pharmacologica Sinica

Volume: 29, P: 736-744
Lineage-specific rearrangement of chromatin loops and epigenomic features during adipocytes and osteoblasts commitment

Ruo-Han Hao
Yan Guo
Tie-Lin Yang
Research29 Jul 2022
Cell Death & Differentiation

Volume: 29, P: 2503-2518
Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population

Qing Wang and colleagues report a genome-wide association study for coronary artery disease (CAD) in a Chinese Han population. They identify a locus on chromosome 6p24.1 newly associated with CAD.

Fan Wang
Cheng-Qi Xu
Qing K Wang
Research06 Mar 2011
Nature Genetics

Volume: 43, P: 345-349
Ca²⁺ homeostasis maintained by TMCO1 underlies corpus callosum development via ERK signaling

Ke-Yan Yang
Song Zhao
Tie-Shan Tang
ResearchOpen Access04 Aug 2022
Cell Death & Disease

Volume: 13, P: 1-13
Association of serum sodium concentration with coronary atherosclerosis in China: follow-up study

En-zhi Jia
Zhen-xia Xu
Xiang Lu
Research23 Mar 2009
Acta Pharmacologica Sinica

Volume: 30, P: 494-500
Serum sodium concentration is significantly associated with the angiographic characteristics of coronary atherosclerosis

En-zhi Jia
Zhi-jian Yang
Wen-zhu Ma
Research01 Aug 2007
Acta Pharmacologica Sinica

Volume: 28, P: 1136-1142
Negative association between free triiodothyronine level and international normalized ratio in euthyroid subjects with acute myocardial infarction

Li Li
Chang-yan Guo
Zhi-jian Yang
Research03 Oct 2011
Acta Pharmacologica Sinica

Volume: 32, P: 1351-1356
Expression patterns and prognostic value of RUNX genes in kidney cancer

Ke Gao
Fang Zhang
Zhi-Ming Dai
ResearchOpen Access22 Jul 2021
Scientific Reports

Volume: 11, P: 1-10
Novel CACNA1S mutation causes autosomal dominant hypokalemic periodic paralysis in a South American family

Tie Ke
Cladelis Rubio Gomez
Qing Kenneth Wang
Research25 Sept 2009
Journal of Human Genetics

Volume: 54, P: 660-664
Blood metabolites, neurocognition and psychiatric disorders: a Mendelian randomization analysis to investigate causal pathways

Jing Guo
Ping Yang
Yan Guo
ResearchOpen Access16 Sept 2024
Translational Psychiatry

Volume: 14, P: 1-13
Frequency-modulated continuous waves controlled by space-time-coding metasurface with nonlinearly periodic phases

A novel theoretical framework and method, which is based on a novel space-time-coding metasurface (STCM) with nonlinearly periodic phases, is proposed to generate frequency-modulated continuous waves (FMCWs) and dynamically control their spatial propagation behaviors simultaneously.

Jun Chen Ke
Jun Yan Dai
Tie Jun Cui
ResearchOpen Access14 Sept 2022
Light: Science & Applications

Volume: 11, P: 1-11
A novel de novo frame-shift mutation of the EDA gene in a Chinese Han family with hypohidrotic ectodermal dysplasia

Changzheng Huang
Qinbo Yang
Mugen Liu
Research01 Dec 2006
Journal of Human Genetics

Volume: 51, P: 1133-1137
A full-width half-maximum method to assess retinal vascular structural changes in patients with ischemic heart disease and microvascular angina

Bo Lun Xu
Wen Li Zhou
Yu Hua Tong
ResearchOpen Access29 Jul 2019
Scientific Reports

Volume: 9, P: 1-9
Vitamin K epoxide reductase and its paralogous enzyme have different structures and functions

Balaji Chandra Sekhar Sinhadri
Da-Yun Jin
Jian-Ke Tie
ResearchOpen Access15 Dec 2017
Scientific Reports

Volume: 7, P: 1-12
TMCO1 is essential for ovarian follicle development by regulating ER Ca²⁺ store of granulosa cells

Zhongshuai Sun
Hui Zhang
Tie-Shan Tang
ResearchOpen Access21 Feb 2018
Cell Death & Differentiation

Volume: 25, P: 1686-1701
Author Correction: A full-width half-maximum method to assess retinal vascular structural changes in patients with ischemic heart disease and microvascular angina

Bo Lun Xu
Wen Li Zhou
Yu Hua Tong
Amendments and CorrectionsOpen Access06 Dec 2019
Scientific Reports

Volume: 9, P: 1

Search

Revealing the genetic architectures underlying organ-specific aging based on proteomic data

Deoxygenative radical cross-coupling of C(sp³)−O/C(sp³)−H bonds promoted by hydrogen-bond interaction

Electric bias-induced reversible configuration of single and heteronuclear dual-atom catalysts on 1Tʹ-MoS₂

Simplified radar architecture based on information metasurface

Structure and mechanism of vitamin-K-dependent γ-glutamyl carboxylase

Mendelian randomization analyses support causal relationships between brain imaging-derived phenotypes and risk of psychiatric disorders

A filtering reconfigurable intelligent surface for interference-free wireless communications

A transcription factor ZmGLK36 confers broad resistance to maize rough dwarf disease in cereal crops

Genomic insights into the formation of human populations in East Asia

Histidine kinase MHZ1/OsHK1 interacts with ethylene receptors to regulate root growth in rice

Manipulations of multi-frequency waves and signals via multi-partition asynchronous space-time-coding digital metasurface

Rectifying disorder of extracellular matrix to suppress urethral stricture by protein nanofilm-controlled drug delivery from urinary catheter

A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase

Role of PDGFRA⁺ cells and a CD55⁺ PDGFRA^Lo fraction in the gastric mesenchymal niche

Independent control of harmonic amplitudes and phases via a time-domain digital coding metasurface

The effects of inhibiting IRE1α on the viability of ovarian granulosa cells

Epidemiology, evolution and transmission of human metapneumovirus in Guangzhou China, 2013–2017

Broadband and Broad-Angle Low-Scattering Metasurface Based on Hybrid Optimization Algorithm

Genomic Variants in NEURL, GJA1 and CUX2 Significantly Increase Genetic Susceptibility to Atrial Fibrillation

Association of human carboxypeptidase E exon5 gene polymorphisms with angiographical characteristics of coronary atherosclerosis in a Chinese population

Lineage-specific rearrangement of chromatin loops and epigenomic features during adipocytes and osteoblasts commitment

Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population

Ca²⁺ homeostasis maintained by TMCO1 underlies corpus callosum development via ERK signaling

Association of serum sodium concentration with coronary atherosclerosis in China: follow-up study

Serum sodium concentration is significantly associated with the angiographic characteristics of coronary atherosclerosis

Negative association between free triiodothyronine level and international normalized ratio in euthyroid subjects with acute myocardial infarction

Expression patterns and prognostic value of RUNX genes in kidney cancer

Novel CACNA1S mutation causes autosomal dominant hypokalemic periodic paralysis in a South American family

Blood metabolites, neurocognition and psychiatric disorders: a Mendelian randomization analysis to investigate causal pathways

Frequency-modulated continuous waves controlled by space-time-coding metasurface with nonlinearly periodic phases

A novel de novo frame-shift mutation of the EDA gene in a Chinese Han family with hypohidrotic ectodermal dysplasia

A full-width half-maximum method to assess retinal vascular structural changes in patients with ischemic heart disease and microvascular angina

Vitamin K epoxide reductase and its paralogous enzyme have different structures and functions

TMCO1 is essential for ovarian follicle development by regulating ER Ca²⁺ store of granulosa cells

Author Correction: A full-width half-maximum method to assess retinal vascular structural changes in patients with ischemic heart disease and microvascular angina

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