Specific gene expression patterns must be tightly regulated for eukaryotic cells to acquire unique structural and functional features. A key step is transcriptional initiation, during which epigenetic activators are thought to facilitate the process by establishing and maintaining transcription-competent chromatin structures. Accumulating evidence shows that an epigenetic regulator can also control the next step — transcriptional elongation.
- Tilman Sanchez-Elsner
- Frank Sauer
