Nature Search

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

Both rare and common variants contribute to the aetiology of complex traits such as type 2 diabetes (T2D). Here, the authors examine the effect of coding variation on glycaemic traits and T2D, and identify low-frequency variation in GLP1Rsignificantly associated with these traits.

Jennifer Wessel
Audrey Y Chu
Mark O Goodarzi
ResearchOpen Access29 Jan 2015
Nature Communications

Volume: 6, P: 1-16
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

Ruth Loos and colleagues use genome-wide association to identify common variants influencing body fat percentage. Unexpectedly, they show that a body-fat–decreasing allele near IRS1 is associated with an impaired metabolic profile, including increased risk of type 2 diabetes and coronary artery disease.

Tuomas O Kilpeläinen
M Carola Zillikens
Ruth J F Loos
Research26 Jun 2011
Nature Genetics

Volume: 43, P: 753-760
Global terrestrial nitrogen fixation and its modification by agriculture

Biological nitrogen fixation may impose stronger constraints on the carbon sink in natural terrestrial biomes and represent a larger source of agricultural nitrogen than is generally considered in analyses of the global nitrogen cycle.

Carla R. Reis Ely
Steven S. Perakis
Nina Wurzburger
Research16 Jul 2025
Nature

Volume: 643, P: 705-711
A birth certificate for CD2

Timothy A. Springer
News & Views24 Oct 1991
Nature

Volume: 353, P: 704-705
Single stretch-activated ion channels in vascular endothelial cells as mechanotransducers?

Jeffry B. Lansman
Trevor J. Hallam
Timothy J. Rink
Research26 Feb 1987
Nature

Volume: 325, P: 811-813
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Erik Ingelsson and colleagues report a large-scale genome-wide meta-analysis for associations to the extremes of anthropometric traits, including body mass index, height, waist-to-hip ratio and clinical obesity. They identify four loci newly associated with height and seven loci newly associated with clinical obesity and find overlap in the genetic structure and distribution of variants identified for these extremes of the trait distributions and for the general population.

Sonja I Berndt
Stefan Gustafsson
Erik Ingelsson
Research07 Apr 2013
Nature Genetics

Volume: 45, P: 501-512
Amygdala activity related to enhanced memory for pleasant and aversive stimuli

Stephan B. Hamann
Timothy D. Ely
Clinton D. Kilts
Research01 Mar 1999
Nature Neuroscience

Volume: 2, P: 289-293
Defining the role of common variation in the genomic and biological architecture of adult human height

Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci significantly associated with adult height and find that these variants cluster in pathways involved in growth and together explain one-fifth of the heritability for this trait.

Andrew R Wood
Tonu Esko
Timothy M Frayling
Research05 Oct 2014
Nature Genetics

Volume: 46, P: 1173-1186
A novel dimer configuration revealed by the crystal structure at 2.4 Å resolution of human interleukin-5

Michael V. Milburn
Anne M. Hassell
Timothy N. C. Wells
Research13 May 1993
Nature

Volume: 363, P: 172-176
Output from VIP cells of the mammalian central clock regulates daily physiological rhythms

VIP-expressing neurons play a central role in circadian timekeeping within the mammalian central clock. Here the authors use opto- and chemogenetic approaches to show that VIP neuronal activity regulates rhythmic activity in downstream hypothalamic target neurons and their physiological functions.

Sarika Paul
Lydia Hanna
Timothy M. Brown
ResearchOpen Access19 Mar 2020
Nature Communications

Volume: 11, P: 1-14
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

Eleftheria Zeggini
Laura J Scott
David Altshuler
Research30 Mar 2008
Nature Genetics

Volume: 40, P: 638-645
Spontaneous astrocytic Ca²⁺ oscillations in situ drive NMDAR-mediated neuronal excitation

H. Rheinallt Parri
Timothy M. Gould
Vincenzo Crunelli
Research01 Aug 2001
Nature Neuroscience

Volume: 4, P: 803-812
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

The MAGIC investigators report results of a large genome-wide association study meta-analysis to identify common variants influencing fasting glucose homeostasis. They further show that several of the newly discovered loci influencing glycemic traits are also associated with risk of type 2 diabetes.

Josée Dupuis
Claudia Langenberg
Inês Barroso
Research17 Jan 2010
Nature Genetics

Volume: 42, P: 105-116
Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

Luca Lotta, Robert Scott, Stephen O’Rahilly, Claudia Langenberg, David Savage, Nicholas Wareham, Inês Barroso and colleagues identify 53 genomic regions associated with insulin resistance phenotypes. Their findings suggest that limited storage capacity of peripheral adipose tissue is an important etiological component in insulin-resistant cardiometabolic disease and highlight genes and mechanisms underpinning this link.

Luca A Lotta
Pawan Gulati
Robert A Scott
Research14 Nov 2016
Nature Genetics

Volume: 49, P: 17-26
Defining the r factor for post-trauma resilience and its neural predictors

The authors report data from the emergency department AURORA study to characterize resilience in more detail than the absence of psychopathology after trauma.

Sanne J. H. van Rooij
Justin L. Santos
Jennifer S. Stevens
Research22 Apr 2024
Nature Mental Health

Volume: 2, P: 680-693
Publisher Correction: Delirium

Jo Ellen Wilson
Matthew F. Mart
E. Wesley Ely
Amendments and Corrections01 Dec 2020
Nature Reviews Disease Primers

Volume: 6, P: 1
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

Richard Watanabe and colleagues of the MAGIC consortium report meta-analyses of genome-wide association studies to glucose levels two hours after an oral glucose challenge. They identify variants in GIPR associated with glucose and insulin responses.

Richa Saxena
Marie-France Hivert
Richard M Watanabe
Research17 Jan 2010
Nature Genetics

Volume: 42, P: 142-148
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Paul R Burton
David G Clayton
Matthew A Brown
Research21 Oct 2007
Nature Genetics

Volume: 39, P: 1329-1337
A global dataset of terrestrial biological nitrogen fixation

Carla R. Reis Ely
Steven S. Perakis
Nina Wurzburger
ResearchOpen Access05 Aug 2025
Scientific Data

Volume: 12, P: 1-10
Author Correction: Defining the r factor for post-trauma resilience and its neural predictors

Sanne J. H. van Rooij
Justin L. Santos
Jennifer S. Stevens
Amendments and Corrections26 Apr 2024
Nature Mental Health

Volume: 2, P: 627
Common variants near MC4R are associated with fat mass, weight and risk of obesity

Ruth J F Loos
Cecilia M Lindgren
Inês Barroso
Research04 May 2008
Nature Genetics

Volume: 40, P: 768-775
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Genome-wide association studies (GWAS) have become a key tool to discover genetic markers for complex traits; however, environmental factors that interact with genes are rarely considered. Here, the authors conduct a GWAS of obesity traits, and find that smoking may alter genetic susceptibilities.

Anne E. Justice
Thomas W. Winkler
L Adrienne Cupples
ResearchOpen Access26 Apr 2017
Nature Communications

Volume: 8, P: 1-19
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

This meta-analysis of genome-wide association studies identifies four genetic loci associated with circulating leptin levels independent of adiposity. Examination in mouse adipose tissue explants provides functional support for the leptin-associated loci.

Tuomas O. Kilpeläinen
Jayne F. Martin Carli
Ruth J. F. Loos
ResearchOpen Access01 Feb 2016
Nature Communications

Volume: 7, P: 1-14
Author Correction: SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC)

Amy D. Proal
Michael B. VanElzakker
E. John Wherry
Amendments and Corrections18 Sept 2023
Nature Immunology

Volume: 24, P: 1778
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

An exciting genome-wide association study in the British population for seven common diseases. This analysis confirms previously identified loci and provides strong evidence for many novel disease susceptibility loci.

Paul R. Burton
David G. Clayton
Jane Worthington
Research07 Jun 2007
Nature

Volume: 447, P: 661-678
Common variants in WFS1 confer risk of type 2 diabetes

Manjinder S Sandhu
Michael N Weedon
Inês Barroso
Research01 Jul 2007
Nature Genetics

Volume: 39, P: 951-953
Sequential decreases in basolateral amygdala response to threat predict failure to recover from PTSD

Alyssa R. Roeckner
Esther R.-H. Lin
Jennifer S. Stevens
Research03 May 2025
Neuropsychopharmacology

Volume: 50, P: 1573-1582
SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC)

Proal and colleagues review the evidence for long-term persistence of coronavirus SARS-CoV-2 in tissues of infected individuals and discuss how this viral reservoir may contribute to the pathogenesis of post-acute sequelae of COVID-19 (PASC).

Amy D. Proal
Michael B. VanElzakker
E. John Wherry
Reviews04 Sept 2023
Nature Immunology

Volume: 24, P: 1616-1627
Towards a global DNA barcode reference library for quarantine identifications of lepidopteran stemborers, with an emphasis on sugarcane pests

Timothy R. C. Lee
Stacey J. Anderson
Andrew Mitchell
ResearchOpen Access07 May 2019
Scientific Reports

Volume: 9, P: 1-19
Increases in Renal ε-(γ-Glutamyl)-Lysine Crosslinks Result from Compartment-Specific Changes in Tissue Transglutaminase in Early Experimental Diabetic Nephropathy: Pathologic Implications

N James Skill
Martin Griffin
Timothy S Johnson
Research01 May 2001
Laboratory Investigation

Volume: 81, P: 705-716
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

New methods and larger sample groups are used to precisely determine the alleles in the HLA complex which contribute susceptibility to type 1 diabetes.

Sergey Nejentsev
Joanna M. M. Howson
Jane Worthington
Research14 Nov 2007
Nature

Volume: 450, P: 887-892
Delirium

Delirium is a severe neuropsychiatric syndrome characterized by an acute change in attention, awareness and cognition and is caused by various medical conditions. This Primer reviews the epidemiology, pathophysiology, diagnosis and classification of delirium as well as its management approaches and discusses future directions in delirium research and treatment.

Jo Ellen Wilson
Matthew F. Mart
E. Wesley Ely
Reviews12 Nov 2020
Nature Reviews Disease Primers

Volume: 6, P: 1-26
Structural inequities contribute to racial/ethnic differences in neurophysiological tone, but not threat reactivity, after trauma exposure

Nathaniel G. Harnett
Negar Fani
Kerry J. Ressler
ResearchOpen Access01 Feb 2023
Molecular Psychiatry

Volume: 28, P: 2975-2984
Chronic Lithium Treatment Decreases Neuronal Activity in the Nucleus Accumbens and Cingulate Cortex of the Rat

Philip D Lambert
Kathleen M McGirr
Michael J Kuhar
Research01 Aug 1999
Neuropsychopharmacology

Volume: 21, P: 229-237
Diagnosis and management of migraine in ten steps

In this Consensus Statement, which is endorsed by the European Headache Federation and the European Academy of Neurology, an expert panel provides recommendations for the diagnosis and management of migraine to support clinical decision-making by general practitioners, neurologists and headache specialists.

Anna K. Eigenbrodt
Håkan Ashina
Messoud Ashina
ReviewsOpen Access18 Jun 2021
Nature Reviews Neurology

Volume: 17, P: 501-514
Internal capsule microstructure mediates the relationship between childhood maltreatment and PTSD following adulthood trauma exposure

Samantha A. Wong
Lauren A. M. Lebois
Nathaniel G. Harnett
ResearchOpen Access17 Mar 2023
Molecular Psychiatry

Volume: 28, P: 5140-5149
Structural covariance of the ventral visual stream predicts posttraumatic intrusion and nightmare symptoms: a multivariate data fusion analysis

Nathaniel G. Harnett
Katherine E. Finegold
Jennifer S. Stevens
ResearchOpen Access08 Aug 2022
Translational Psychiatry

Volume: 12, P: 1-13
Erratum: The Neural Correlates of Social Anxiety Disorder and Response to Pharmacotherapy

Clinton D Kilts
Jeffrey E Kelsey
Charles B Nemeroff
Amendments and Corrections18 Sept 2006
Neuropsychopharmacology

Volume: 31, P: 2254
Prognostic neuroimaging biomarkers of trauma-related psychopathology: resting-state fMRI shortly after trauma predicts future PTSD and depression symptoms in the AURORA study

Nathaniel G. Harnett
Sanne J. H. van Rooij
Jennifer S. Stevens
Research21 Jan 2021
Neuropsychopharmacology

Volume: 46, P: 1263-1271
The United States COVID-19 Forecast Hub dataset

Estee Y. Cramer
Yuxin Huang
Nicholas G. Reich
ResearchOpen Access01 Aug 2022
Scientific Data

Volume: 9, P: 1-15
Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

Zuzana Kos
Elvire Roblin
Zsuzsanna Bago-Horvath
ResearchOpen Access12 May 2020
npj Breast Cancer

Volume: 6, P: 1-16
The Neural Correlates of Social Anxiety Disorder and Response to Pharmacotherapy

Clinton D Kilts
Jeffrey E Kelsey
Charles B Nemeroff
Research08 Mar 2006
Neuropsychopharmacology

Volume: 31, P: 2243-2253
White Matter Integrity in Highly Traumatized Adults With and Without Post-Traumatic Stress Disorder

Negar Fani
Tricia Z King
Kerry J Ressler
Research08 Aug 2012
Neuropsychopharmacology

Volume: 37, P: 2740-2746
The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

Khalid El Bairi
Harry R. Haynes
Paul J. Van Diest
ReviewsOpen Access01 Dec 2021
npj Breast Cancer

Volume: 7, P: 1-17
Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

Jan Hudeček
Leonie Voorwerk
Zsuzsanna Bago-Horvath
ReviewsOpen Access12 May 2020
npj Breast Cancer

Volume: 6, P: 1-8
Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group

Mohamed Amgad
Elisabeth Specht Stovgaard
Zaheed Husain
ReviewsOpen Access12 May 2020
npj Breast Cancer

Volume: 6, P: 1-13

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