Glycogen has an important role in cardiac development and function. In this Review, Pinós and colleagues discuss the cardiovascular manifestations of glycogen storage diseases caused by rare inherited deficiencies of enzymes involved either in glycogen synthesis or breakdown, or in glycolysis. Interventions, including gene therapies, for these conditions are also summarized.
- Tomàs Pinós
- Richard M. Cubbon
- Alejandro Lucia