Nature Search

Hospital load and increased COVID-19 related mortality in Israel

COVID-19 has caused many healthcare systems to become overwhelmed, potentially impacting patient care. Here, the authors show that COVID-19-related in-hospital mortality rates in Israel increased in periods of moderate or high hospital load, independent of patient characteristics.

Hagai Rossman
Tomer Meir
Malka Gorfine
ResearchOpen Access26 Mar 2021
Nature Communications

Volume: 12, P: 1-7
Correlates of protection for booster doses of the SARS-CoV-2 vaccine BNT162b2

Vaccination with multiple doses has been proven effective against severe COVID-19, but protection levels widely vary among individuals. This study examines the serological and immunological profiles in recipients of multiple doses of Pfizer BNT162b2 vaccine for immune markers that correlate with protection against and susceptibility for SARS-CoV-2 infection.

Tomer Hertz
Shlomia Levy
Orly Weinstein
ResearchOpen Access29 Jul 2023
Nature Communications

Volume: 14, P: 1-16
p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells

Majewska et al. show that p16-expressing senescent cells enhance the stability of the immune checkpoint PD-L1 by downregulating its proteasome-mediated ubiquitin-dependent degradation, leading to their accumulation in ageing and chronic inflammation.

Julia Majewska
Amit Agrawal
Valery Krizhanovsky
ResearchOpen Access05 Aug 2024
Nature Cell Biology

Volume: 26, P: 1336-1345
Author Correction: Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis

Yael Aylon
Noa Furth
Moshe Oren
Amendments and CorrectionsOpen Access10 Jan 2023
Nature Communications

Volume: 14, P: 1
Targeting CD38 immunometabolic checkpoint improves metabolic fitness and cognition in a mouse model of Alzheimer’s disease

Maladaptive immunity negatively impacts Alzheimer’s disease (AD). Here, the authors show dysfunctional CD38-expressing CD4⁺ T cells in individuals with familial AD before symptom onset. Targeting CD38 in an AD mouse model restored metabolic fitness, improved cognition, and modified meningeal immunity.

Javier María Peralta Ramos
Giulia Castellani
Michal Schwartz
ResearchOpen Access20 Apr 2025
Nature Communications

Volume: 16, P: 1-17
High-dimensional imaging using combinatorial channel multiplexing and deep learning

Protein imaging is multiplexed using combinatorial staining and deep learning decompression.

Raz Ben-Uri
Lior Ben Shabat
Leeat Keren
Research25 Mar 2025
Nature Biotechnology

P: 1-14
Identification of senescent, TREM2-expressing microglia in aging and Alzheimer’s disease model mouse brain

Neuroinflammation and microglia significantly contribute to Alzheimer’s disease pathology, depending on their activation state. We found that TREM2-expressing microglia are a heterogenous population spanning activated to senescent cells.

Noa Rachmian
Sedi Medina
Michal Schwartz
Research18 Apr 2024
Nature Neuroscience

Volume: 27, P: 1116-1124
COVID-19 dynamics after a national immunization program in Israel

A retrospective analysis of data from the Israeli Ministry of Health collected between 28 August 2020 and 24 February 2021 documents the real-life effect of a national vaccination campaign on the pandemic dynamics.

Hagai Rossman
Smadar Shilo
Eran Segal
Research19 Apr 2021
Nature Medicine

Volume: 27, P: 1055-1061
Dissecting cellular crosstalk by sequencing physically interacting cells

PIC-seq characterizes cellular crosstalk by sorting and sequencing physically interacting cells.

Amir Giladi
Merav Cohen
Ido Amit
Research09 Mar 2020
Nature Biotechnology

Volume: 38, P: 629-637
Decorating bacteria with self-assembled synthetic receptors

Cell surface proteins mediate the interactions between cells and their extracellular environment. Here the authors design synthetic biomemetic receptor-like sensors that facilitate programmable interactions between bacteria and their target.

Naama Lahav-Mankovski
Pragati Kishore Prasad
David Margulies
ResearchOpen Access10 Mar 2020
Nature Communications

Volume: 11, P: 1-12
Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis

LATS1 is reported to regulate the transition of luminal-basal-like cell plasticity in breast cancer. Here the authors report that LATS1 limits the progression of luminal breast cancer by associating with NCOR1 nuclear corepressor to repress ERα-downregulated genes in luminal cells.

Yael Aylon
Noa Furth
Moshe Oren
ResearchOpen Access28 Nov 2022
Nature Communications

Volume: 13, P: 1-20
Acute liver failure is regulated by MYC- and microbiome-dependent programs

A single-cell map of transcriptomic changes during acute liver failure unveils new insights into pathogenesis and potential therapeutic targets.

Aleksandra A. Kolodziejczyk
Sara Federici
Eran Elinav
Research26 Oct 2020
Nature Medicine

Volume: 26, P: 1899-1911
Publisher Correction: Building an international consortium for tracking coronavirus health status

Eran Segal
Feng Zhang
Paul Wilmes
Amendments and Corrections26 Jun 2020
Nature Medicine

Volume: 26, P: 1309
Wishbone identifies bifurcating developmental trajectories from single-cell data

Cell differentiation is accurately modeled by an algorithm that orders single cells along branched developmental trajectories.

Manu Setty
Michelle D Tadmor
Dana Pe'er
Research02 May 2016
Nature Biotechnology

Volume: 34, P: 637-645
Food-seeking behavior is triggered by skin ultraviolet exposure in males

Ultraviolet exposure on the skin promotes food intake and body weight gain in males, but not females, by increasing ghrelin expression in skin adipocytes.

Shivang Parikh
Roma Parikh
Carmit Levy
ResearchOpen Access11 Jul 2022
Nature Metabolism

Volume: 4, P: 883-900
Building an international consortium for tracking coronavirus health status

We call upon the research community to standardize efforts to use daily self-reported data about COVID-19 symptoms in the response to the pandemic and to form a collaborative consortium to maximize global gain while protecting participant privacy.

Eran Segal
Feng Zhang
Paul Wilmes
Comments & Opinion02 Jun 2020
Nature Medicine

Volume: 26, P: 1161-1165
Myeloid derived suppressor cells mediate hepatocyte proliferation and immune suppression during liver regeneration following resection

Ido Nachmany
Shir Nevo
Niv Pencovich
Research02 Nov 2024
Genes & Immunity

Volume: 25, P: 483-491
Intense laser interaction with micro-bars

Michal Elkind
Itamar Cohen
Ishay Pomerantz
ResearchOpen Access04 Dec 2023
Scientific Reports

Volume: 13, P: 1-8
CSNAP, the smallest CSN subunit, modulates proteostasis through cullin-RING ubiquitin ligases

Maria G. Füzesi-Levi
Irit Fainer
Michal Sharon
Research31 Jul 2019
Cell Death & Differentiation

Volume: 27, P: 984-998
Stress-related emotional and behavioural impact following the first COVID-19 outbreak peak

Asaf Benjamin
Yael Kuperman
Alon Chen
ResearchOpen Access04 Aug 2021
Molecular Psychiatry

Volume: 26, P: 6149-6158
High-resolution tracking of unconfined zebrafish behavior reveals stimulatory and anxiolytic effects of psilocybin

Dotan Braun
Ayelet M. Rosenberg
Takashi Kawashima
ResearchOpen Access17 Jan 2024
Molecular Psychiatry

Volume: 29, P: 1046-1062
A CD40 Kozak sequence polymorphism and susceptibility to antibody-mediated autoimmune conditions: the role of CD40 tissue-specific expression

E M Jacobson
A K Huber
Y Tomer
Research08 Mar 2007
Genes & Immunity

Volume: 8, P: 205-214

Search

Hospital load and increased COVID-19 related mortality in Israel

Correlates of protection for booster doses of the SARS-CoV-2 vaccine BNT162b2

p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells

Author Correction: Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis

Targeting CD38 immunometabolic checkpoint improves metabolic fitness and cognition in a mouse model of Alzheimer’s disease

High-dimensional imaging using combinatorial channel multiplexing and deep learning

Identification of senescent, TREM2-expressing microglia in aging and Alzheimer’s disease model mouse brain

COVID-19 dynamics after a national immunization program in Israel

Dissecting cellular crosstalk by sequencing physically interacting cells

Decorating bacteria with self-assembled synthetic receptors

Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis

Acute liver failure is regulated by MYC- and microbiome-dependent programs

Publisher Correction: Building an international consortium for tracking coronavirus health status

Wishbone identifies bifurcating developmental trajectories from single-cell data

Food-seeking behavior is triggered by skin ultraviolet exposure in males

Building an international consortium for tracking coronavirus health status

Myeloid derived suppressor cells mediate hepatocyte proliferation and immune suppression during liver regeneration following resection

Intense laser interaction with micro-bars

CSNAP, the smallest CSN subunit, modulates proteostasis through cullin-RING ubiquitin ligases

Stress-related emotional and behavioural impact following the first COVID-19 outbreak peak

High-resolution tracking of unconfined zebrafish behavior reveals stimulatory and anxiolytic effects of psilocybin

A CD40 Kozak sequence polymorphism and susceptibility to antibody-mediated autoimmune conditions: the role of CD40 tissue-specific expression

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