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Two high-redshift post-starburst galaxies are in the process of quenching, although their quasars remain active, indicating the complex co-evolution between black hole activity and star formation.

Amorphous silicon monoxide is known to undergo disproportionation to silicon- and silicon dioxide-like regions, however direct observation of the atomic-scale heterogeneity is still missing. Here, the authors use angstrom-beam electron diffraction to reveal precise structural details of this unusual material.

The effect of aliovalent doping on grain boundary is not yet fully understood at the atomic level. Here, the authors report grain boundary structural transformation in α-Al₂O₃ is induced by co-segregation of multiple dopants using atomic-resolution electron microscopy and theoretical calculations.

Arrays of quantum dots can exhibit a variety of quantum properties, being sensitive to their spacing. Here, the authors fine tune interdot coupling using hexagonal molecular networks in which the dots are separated by single or double haloaromatic compounds, structurally identical but for a single atom.

A linear relationship between spin and momentum relaxation shows that the spin relaxation in an organic semiconductor crystal that has ultra-long spin lifetimes and coherent band-like transport is governed by the Elliott–Yafet mechanism.

Images and spectroscopy obtained by the JWST from two HSC-SSP quasars show massive, compact and disc-like galaxies, indicating that the relation between black holes and their host galaxies was in place less than a billion years after the Big Bang.

Grain boundary atomic structures of crystalline materials have long been believed to be commensurate with the crystal periodicity of the adjacent crystals. Here, the authors discover an incommensurate grain boundary structure based on direct observations and theoretical calculations.

The mobility of organic semiconductors can be tuned by modifying their chemical composition or crystalline properties. Here, the authors show that bending organic single crystals increases their field effect transistor mobility due to restrained molecular vibrations and subsequently reduced dynamic disorder.

Genome-wide analysis shows that H2B S112 O-linked to N-acetylglucosamine is frequently located near transcribed genes, suggesting that histone GlcNAcylation facilitates transcription of the genes.

Though literature reports improvements in organic electronic device performance, understanding the correlation between static and dynamic device responses remains a challenge. Here, the authors correlate static and dynamic parameters in organic transistors by using the radiofrequency circuit model.

A two-dimensional hole gas with high carrier density is confined at the interface between a solution-processed, single-crystalline organic semiconducting film and the electric double layer formed by an ion gel on top of the film.

Diabetes is a major cause of kidney disease. Here Kikuchi et al. show that phenol sulfate, a gut microbiota-derived metabolite, is increased in diabetic kidney disease and contributes to the pathology by promoting kidney injury, suggesting phenyl sulfate could be used a marker and therapeutic target for the treatment of diabetic kidney disease.

Long-term depression of synapses is mediated by the endocytosis of AMPA receptors. Matsuda et al.show that stargazin mediates both AMPA receptor internalization and subsequent endosomal sorting through sequential interactions with two different endocytic adapters.

DNA damage response (DDR) is activated in cardiomyocytes of the failing heart, but the type of DNA damage leading to DDR is unclear. Higoet al. show that in mice heart failure is caused in part by unrepaired DNA single-strand breaks in cardiomyocytes, which activate persistent DDR and trigger an NF-κB-dependent cardiac inflammation.

A consortium reports the tripling of the number of genetic markers in Phase II of the International HapMap Project. This map of human genetic variation will continue to revolutionize discovery of susceptibility loci in common genetic diseases, and study of genes under selection in humans.

Three-dimensional hydrodynamic simulations show that head-on galaxy collisions can suppress black hole fuelling by stripping the torus-shaped gas surrounding the massive black hole. Galaxy collisions could therefore either switch off or turn on nuclear activity, depending on the collision orbit.

Shiro Ikegawa and colleagues report the results of a genome-wide association study for ossification of the posterior longitudinal ligament of the spine in a Japanese cohort. They identify six new loci, three of which showed decreased expression in a mouse model of endochondral ossification.

n-type organic semiconductors exhibiting two-dimensional isotropic charge transport are rarely reported. Here the authors show that using bulky substituents, BQQDI demonstrates near-isotropic charge transport, resilience to dynamic disorder, as well as high electron mobility both in single- and polycrystalline thin-film transistors.

The limitations of conventional chemical doping of polymeric semiconductors can be overcome by adding a second ionic species into the system, leading to enhanced doping, electrical conductivity and stability.

Terminator-assisted solid-phase cDNA amplification and sequencing (TASseq) uses a terminator, terminal transferase and bead-based platform to improve generation of single-cell RNA-seq libraries.

Nakamura et al. used expression studies to identify an enrichment of Zfhx4 in cartilage and revealed through global gene knock-down that it is required for proper endochondral ossification in mice. They further demonstrated a physical and genetic interaction between Zfhx4 and Osterix, which is of interest to the field of transcriptional regulation of mammalian endochondral ossification.

Sabeti et al. build on their This paper builds on previous work of detecting selection on human genes, using the many more markers available in the Phase II HapMap project. Three examples of apparent population-specific selection based on geographic area are described, and how these may relate to human biology is discussed.

Molecular doping of π-conjugated semiconducting polymers can increase charge carrier density. Here, guest dopants are found to locate in the restricted void space in the lamellae, revealing an intercalated compound composed of layered polymer and guest intercalant.

Organic field-effect transistors are expected to become a key component of future integrated circuits. The authors seek to improve the performance of devices based on these materials by investigating the effect of flicker noise in a solution-processed organic single crystal transistor.

Organic molecules exhibit intrinsic semiconducting properties as well as increased flexibility in comparison to their silicon counterparts and consequently are playing an increasing role in semiconductor technologies. Here, the authors demonstrate that monolayers of organic crystals can undergo deformation at the molecular level when in proximity to a substrate and that this has an effect on their electronic structure.