Vinca alkaloids, tubulin-binding agents that impair microtubule growth, are widely used in cancer treatment. Here, the authors show that resistance to these drugs is due to Hepatoma up-regulated protein (HURP) competitively binding to the same site on tubulin, countering the drug’s effects.
- Athira Saju
- Po-Pang Chen
- Kuo-Chiang Hsia
