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Showing 1–3 of 3 results
Advanced filters: Author: Ulf Yrlid Clear advanced filters

  • Fucosylation of host glycoproteins is revealed to sensitize cells to cholera intoxication while fucosylation of host glycolipids is protective. The glycosyltransferases encoded by B3GALT5 and B3GNT5 are identified as key regulators of this phenomenon.

    • Atossa C. Ghorashi
    • Andrew Boucher
    • Jennifer J. Kohler
    Research
    Nature Chemical Biology
    Volume: 21, P: 555-566

  • Gut lumen antigens must be continuously sampled by the immune system to maintain proper immune homeostasis. Here the authors show that activated CCR6+CCR1+GL7- gut B cells retrieve lumen antigens from specialized M cells and transfer them across the subepithelial dome in the Peyer’s patch to contribute to the maintenance of gut humoral immunity.

    • Rathan Joy Komban
    • Anneli Strömberg
    • Nils Lycke
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Self-reactive B cells producing autoantibodies are associated with autoimmune conditions. Here, the authors show that in mice lacking the surrogate light chain, which normally assembles with antibody heavy chain to form a pre-B-cell receptor, the autoantibody-producing cells derive from germinal centres.

    • Ola Grimsholm
    • Weicheng Ren
    • Inga-Lill Mårtensson
    Research
    Nature Communications
    Volume: 6, P: 1-12