Emily Wong et al. observe that Mycobacterium tuberculosis (Mtb) infection induces recruitment and expansion of a CD8+ TRAV1-2+ T-cell population in the airways of human patients. T cell receptor analysis showed expansion of this cell population, including oligoclonal MAIT cells, in sites where Mtb antigens are present, suggesting they act as sentinels of pulmonary infection.
- Emily B. Wong
- Marielle C. Gold
- David M. Lewinsohn