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Showing 1–3 of 3 results
Advanced filters: Author: Utsarga Adhikary Clear advanced filters

  • Resistance mutations in BCL-2 reduce the clinical efficacy of venetoclax. DeAngelo et al. show stapled BAD BH3 peptides can retain and even enhance binding to these mutants, offering a structurally informed strategy to overcome this mechanism of cancer drug resistance.

    • Thomas M. DeAngelo
    • Utsarga Adhikary
    • Loren D. Walensky
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • A disulfide tethering screen identified a molecule that covalently interacts with pro-apoptotic BAX at C126, inhibiting its activation.

    • Matthew W. McHenry
    • Peiwen Shi
    • Loren D. Walensky
    Research
    Nature Chemical Biology
    Volume: 20, P: 1022-1032