DNA cytosine methylation has essential roles in a number of cellular processes. Here, the first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome — from both human embryonic stem cells and fetal fibroblasts — are presented, along with analyses of the transcriptome, histone modifications, and sites of DNA–protein interaction for several regulatory factors. The results reveal key differences in methylation patterns between the two genomes.
- Ryan Lister
- Mattia Pelizzola
- Joseph R. Ecker
