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Showing 1–5 of 5 results
Advanced filters: Author: Vasileios C. Kyttaris Clear advanced filters

  • CD38 has been reported to be upregulated on T cells in lupus with unclear functional consequences. Here the authors show that CD4+CD38+ T cells from lupus patients have altered calcium homeostasis accompanied by alteration in cell membrane lipid composition and a suppression of IL-2.

    • Eri Katsuyama
    • Morgane Humbel
    • George C. Tsokos
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Systemic lupus erythematosus (SLE) is a complex autoimmune disease with diverse clinical manifestations. This Review discusses advances in understanding its immunopathogenesis, the evolution of targeted therapeutic strategies, and emerging approaches to restore immune tolerance. Challenges and opportunities in achieving durable remission or cure in SLE are also explored.

    • Marc Scherlinger
    • Antonios G. A. Kolios
    • George C. Tsokos
    Reviews
    Nature Reviews Drug Discovery
    P: 1-19

  • ICER is a CREM splice variant that represses CREM/CREB signalling. Here the authors use human cells and mouse models of various autoimmune diseases to show that ICER is central to pathogenic Th17 cell differentiation in autoimmunity.

    • Nobuya Yoshida
    • Denis Comte
    • George C. Tsokos
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Recent advances have shed light on the biochemical and molecular aberrations that lead to the characteristic cytokine production pattern and altered behavior of T cells in systemic lupus erythematosus (SLE). This article reviews how this knowledge helps explain the nature of the SLE T cell, identifies therapeutic targets that deserve further development, and identifies biomarkers of disease activity.

    • José C. Crispín
    • Vasileios C. Kyttaris
    • George C. Tsokos
    Reviews
    Nature Reviews Rheumatology
    Volume: 6, P: 317-325