Nature Search

Purified dihydropyridine-binding site from skeletal muscle t-tubules is a functional calcium channel

Veit Flockerzi
Hans-Jochem Oeken
Wolfgang Trautwein
Research04 Sept 1986
Nature

Volume: 323, P: 66-68
Primary structure and functional expression from complementary DNA of a brain calcium channel

Yasuo Mori
Thomas Friedrich
Shosaku Numa
Research04 Apr 1991
Nature

Volume: 350, P: 398-402
Primary structure of the receptor for calcium channel blockers from skeletal muscle

Tsutomu Tanabe
Hiroshi Takeshima
Shosaku Numa
Research23 Jul 1987
Nature

Volume: 328, P: 313-318
Normalization of current kinetics by interaction between the α₁and β subunits of the skeletal muscle dihydropyridine-sensitive Ca²⁺ channel

Antonio E. Lacerda
Haeyoung S. Kim
Arthur M. Brown
Research08 Aug 1991
Nature

Volume: 352, P: 527-530
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels

Thomas Voets
Guy Droogmans
Bernd Nilius
Research12 Aug 2004
Nature

Volume: 430, P: 748-754
Author Correction: Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels

Wang Zheng
Xiaoyong Yang
Xing-Zhen Chen
Amendments and CorrectionsOpen Access26 Mar 2019
Nature Communications

Volume: 10, P: 1
Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice

The signalling cascade involved in lung ischaemia–reperfusion-induced oedema is poorly understood. Using knockout mice, Weissmannet al. propose a model in which reactive oxygen species production by endothelial NOX2 leads to phospholipase C-γ activation, DAG kinase inhibition and subsequent TRPC6 activation.

Norbert Weissmann
Akylbek Sydykov
Alexander Dietrich
ResearchOpen Access31 Jan 2012
Nature Communications

Volume: 3, P: 1-10
Lack of an endothelial store-operated Ca²⁺ current impairs agonist-dependent vasorelaxation in TRP4^−/− mice

Marc Freichel
Suk Hyo Suh
Bernd Nilius
Research10 Jan 2001
Nature Cell Biology

Volume: 3, P: 121-127
Tracheal tuft cells release ATP and link innate to adaptive immunity in pneumonia

Tracheal tuft cells have been shown to facilitate the recruitment of immune cells during infection of the airways. Here the authors show that P. aeruginosa lung infection in mice activates tuft cells to release ATP which subsequently activates DC and promotes IL-17A secreting T cells.

Noran Abdel Wadood
Monika I. Hollenhorst
Gabriela Krasteva-Christ
ResearchOpen Access10 Jan 2025
Nature Communications

Volume: 16, P: 1-17
Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels

Mutations in the cation channel PKD2 cause human autosomal dominant polycystic kidney disease but its channel function and gating mechanism are poorly understood. Here authors study PKD2 using electrophysiology and cryo-EM, which identifies hydrophobic gates and proposes a gating mechanism for PKD2.

Wang Zheng
Xiaoyong Yang
Xing-Zhen Chen
ResearchOpen Access13 Jun 2018
Nature Communications

Volume: 9, P: 1-14
De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury

After injury to the spinal cord, hemorrhages occur both near and far from the initial lesion. J. Marc Simard and his colleagues demonstrate that spinal cord injury induces expression of the channel Trpm4 on endothelial cells in the spinal cord, which leads to their fragmentation and the spread of the hemorrhage.

Volodymyr Gerzanich
S Kyoon Woo
J Marc Simard
Research25 Jan 2009
Nature Medicine

Volume: 15, P: 185-191
ORAI2 modulates store-operated calcium entry and T cell-mediated immunity

Ca²⁺ release-activated Ca²⁺(CRAC) channels are essential for protective immunity, but the immunological functions of the three ORAI homologues that form CRAC channels are unclear. Here the authors show that ORAI1 and ORAI2 form heteromeric CRAC channels, which fine-tune T cell activation and immune responses.

Martin Vaeth
Jun Yang
Stefan Feske
ResearchOpen Access15 Mar 2017
Nature Communications

Volume: 8, P: 1-17
Defective survival of naive CD8⁺ T lymphocytes in the absence of the β3 regulatory subunit of voltage-gated calcium channels

T cell activation triggers large calcium fluxes. Flavell and colleagues show tonic calcium signaling via Ca_v1.4-β3 channels are needed for the survival and homeostasis of naive CD8⁺ T cells.

Mithilesh K Jha
Abdallah Badou
Richard A Flavell
Research18 Oct 2009
Nature Immunology

Volume: 10, P: 1275-1282
Expression of the Ca²⁺-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression

Thomas Fixemer
Ulrich Wissenbach
Helmut Bonkhoff
Research30 Oct 2003
Oncogene

Volume: 22, P: 7858-7861
Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic β cells

In an unanticipated cross-talk between the steroid and insulin endocrine systems, the neuroactive steroid pregnenolone sulphate is found to activate the TRPM3 channel, leading to enhanced insulin secretion from pancreatic islets.

Thomas F.J. Wagner
Sabine Loch
Johannes Oberwinkler
Research02 Nov 2008
Nature Cell Biology

Volume: 10, P: 1421-1430
TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis

Axonal and neuronal damage are commonly seen in patients with multiple sclerosis. Manuel A. Friese and his colleagues now report that the cation channel transient receptor potential melastatin 4 (TRPM4) is upregulated in multiple sclerosis lesions in patients and contributes to disease in vivo. Genetic deletion or pharmacological inhibition of TRPM4 in a mouse model of multiple sclerosis reduces clinical scores and is neuroprotective, suggesting this may represent a novel therapeutic target.

Benjamin Schattling
Karin Steinbach
Manuel A Friese
Research18 Nov 2012
Nature Medicine

Volume: 18, P: 1805-1811
Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4

Rudi Vennekens
Jenny Olausson
Marc Freichel
Research11 Feb 2007
Nature Immunology

Volume: 8, P: 312-320
Antihypertensive medications and the risk of kidney stones in older adults: a retrospective cohort study

R Todd Alexander
Eric McArthur
Robert Ross Quinn
Research23 Mar 2017
Hypertension Research

Volume: 40, P: 837-842
Experimental capture of miRNA targetomes: disease-specific 3′UTR library-based miRNA targetomics for Parkinson’s disease

Martin Hart
Fabian Kern
Eckart Meese
ResearchOpen Access01 Apr 2024
Experimental & Molecular Medicine

Volume: 56, P: 935-945
Protonophore properties of hyperforin are essential for its pharmacological activity

Thomas S. Sell
Thabet Belkacemi
Andreas Beck
ResearchOpen Access16 Dec 2014
Scientific Reports

Volume: 4, P: 1-12

Search

Purified dihydropyridine-binding site from skeletal muscle t-tubules is a functional calcium channel

Primary structure and functional expression from complementary DNA of a brain calcium channel

Primary structure of the receptor for calcium channel blockers from skeletal muscle

Normalization of current kinetics by interaction between the α₁and β subunits of the skeletal muscle dihydropyridine-sensitive Ca²⁺ channel

The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels

Author Correction: Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels

Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice

Lack of an endothelial store-operated Ca²⁺ current impairs agonist-dependent vasorelaxation in TRP4^−/− mice

Tracheal tuft cells release ATP and link innate to adaptive immunity in pneumonia

Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels

De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury

ORAI2 modulates store-operated calcium entry and T cell-mediated immunity

Defective survival of naive CD8⁺ T lymphocytes in the absence of the β3 regulatory subunit of voltage-gated calcium channels

Expression of the Ca²⁺-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression

Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic β cells

TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis

Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4

Antihypertensive medications and the risk of kidney stones in older adults: a retrospective cohort study

Experimental capture of miRNA targetomes: disease-specific 3′UTR library-based miRNA targetomics for Parkinson’s disease

Protonophore properties of hyperforin are essential for its pharmacological activity

Search

Quick links

Search

Filter By:

Search

Quick links