Seven single gene mutations are known to cause hypertension, generally by affecting electrolyte transport in the distal nephron, or synthesis or activity of mineralocorticoid hormones. These relatively uncommon disorders should be considered when young patients with a family history of high blood pressure present with severe or refractory hypertension. This article guides clinicians through identification of these defects, their associated laboratory findings, and recommended treatments.
- Vesna D Garovic
- Anthony A Hilliard
- Stephen T Turner
