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Showing 1–2 of 2 results
Advanced filters: Author: Vicky Amo-Addae Clear advanced filters

  • Patients with different small round cell sarcoma (SRCS) often receive the same treatment regimen but for some SRCS subtypes, response to chemotherapy is poor and targeted treatment options are limited. Here, the authors establish a biobank of paediatric patient-derived SRCS tumoroids and perform drug screening, identifying MCL inhibition as a potential therapeutic strategy in CIC::DUX4 sarcomas.

    • Femke C. A. S. Ringnalda
    • Gijs J. F. van Son
    • Hans Clevers
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • WNT-activating mutations in CTNNB1 are common in hepatoblastoma, but downstream molecular phenotypes are heterogenous. Using multiomic approaches, the authors identify distinct subgroups of hepatoblastoma cells based on WNT-signaling patterns and create a biobank of patient-derived hepatoblastoma organoids representing these subtypes.

    • Thomas A. Kluiver
    • Yuyan Lu
    • Weng Chuan Peng
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17