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Showing 1–10 of 10 results
Advanced filters: Author: Virgil Percec Clear advanced filters

  • Chemists usually kick-start reactions with heat, light or electricity, but a far less common option is to use mechanical stress. It now seems that stress not only triggers reactions, but can also direct their course.

    • Brad M. Rosen
    • Virgil Percec
    News & Views
    Nature
    Volume: 446, P: 381-382

  • Targeted delivery to the lower regions of the lung is necessary for the treatment of parenchymal lung injury and disease but is challenging. Here, the authors develop an mRNA delivery platform to treat acute lung injury in mice and demonstrate that it can reach the lower regions of the lung.

    • Jaclynn A. Meshanni
    • Emily R. Stevenson
    • Elena N. Atochina-Vasserman
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • High-throughput methods of synthesis and analysis are streamlining the search for new catalysts, reducing the timescale from years to days. A new class of polymerization catalysts is the latest discovery.

    • Virgil Percec
    News & Views
    Nature
    Volume: 424, P: 135-136

  • The structural order of supramolecular assemblies typically depends on the enantiomeric purity of their building blocks. Now, a perylene bisimide (PBI) derivative has been described that assembles into a single-handed supramolecular helix, which in turn packs into domains with an identical crystalline order irrespective of the PBI's chirality. A cogwheel mechanism is proposed.

    • Cécile Roche
    • Hao-Jan Sun
    • Virgil Percec
    Research
    Nature Chemistry
    Volume: 8, P: 80-89

  • Glycosaminoglycans (GAGs) are one of the most important polysaccharide in the living systems. However, preparation of GAGs is difficult owing to the complex structure and high molecular weight. In order to obtain the GAGs’ materials with a practical way, we investigated a new approach to mimic GAGs using polymer chemistry. We reviewed the syntheses of GAGs of the previous reports and the glycopolymers having GAGs moieties, including our GAGs' mimic polymers.

    • Yoshiko Miura
    • Tomohiro Fukuda
    • Yu Hoshino
    Reviews
    Polymer Journal
    Volume: 48, P: 229-237

  • Glycopolymers with pendant saccharides are biofunctional polymers that interact with saccharide recognition proteins. The glycopolymers show the strong molecular recognition ability owing to the multivalency. These polymers were prepared by the polymerization with sugar derivatives or by the saccharide addition to the polymer backbone. The glycopolymers can be applied for cell cultivation, drug delivery, and biosensing. The living radical polymerization provided the precise structure of glycopolymer, which was useful for analysis of the protein–saccharide interactions. The living radical polymerization also provided the hybrid biomaterials that can be used for biosensing and biomaterials.

    • Yoshiko Miura
    Reviews
    Polymer Journal
    Volume: 44, P: 679-689

  • Polyolefins (polypropylene (PP), polyethylene and so on) and polyolefin rubbers (ethylene propylene diene monomer, ethylene propylene elastomer and so on) are the most widely used polymers. Therefore, a development of a polyolefin and polyolefin rubber–clay nanocomposite has been desired for a long time. As these polyolefin polymers do not include any polar groups in its backbone, it was thought that the homogeneous dispersion of the silicate layers would not be realized. But we have successfully developed these polymer–clay nanocomposites by using various methods.

    • Makoto Kato
    • Arimitsu Usuki
    • Masaya Kawasumi
    Reviews
    Polymer Journal
    Volume: 43, P: 583-593

  • The interaction between synthetic particles and proteins has been studied to identify factors that govern the interaction in vitro. The composition and properties of the protein corona that forms on the surface of NPs have been studied in vivo. Recently, synthetic NPs that recognize target molecules are designed and prepared by optimizing the combination of functional groups on the particles, molecular imprinting, in combination with the affinity purification. Some particles are capable of recognizing target molecules and neutralizing their function, in the bloodstream of living animals, as ‘plastic antibodies.’

    • Yu Hoshino
    • Haejoo Lee
    • Yoshiko Miura
    Reviews
    Polymer Journal
    Volume: 46, P: 537-545