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MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Human antibodies DENV-290 and DENV-115 are ultrapotent against dengue virus 3 strains with differing particle morphologies. CryoEM shows both bind across two protomers at the center of the envelope protein dimer, defining a new class of epitope.

The authors present a microwave imaging system that can operate in continuous transmit-receive mode. Using an array of transmitters, a single receiver and a reconstruction matrix that correlate random time patterns with the captured signal, they demonstrate real-time imaging and tracking through a wall.

Apoptotic cells often release extracellular vesicles that aid in their clearance and provide molecular information to cellular neighbours. Here, the authors show that some adherent apoptotic cells also create vesicles that remain attached at the site of death.

CRISPR-based genome editing therapeutics are entering the clinic, but in vitro and in vivo tools are needed to assess their safety and efficacy. The authors review complementary technologies to monitor the biological effects of genome editing across scales, including the direct measurement of editing outcomes in DNA, human microphysiological systems and non-invasive in vivo imaging.

Experiments with a trapped-ion quantum simulator observe Stark many-body localization, in which the quantum system evades thermalization despite having no disorder.

CRISPR-Cas9 technology holds the potential to treat a wide spectrum of genetic diseases. Here, the authors describe a modular platform for extracellular vesicle-based Cas9 delivery, using MS2-based RNA-binding domains and UV-cleavable linkers, suitable for various Cas9-based moieties.

Two adjacent layers flowing at different velocities in the same fluid are subject to flow instabilities. This phenomenon is now studied in atomic superfluids, revealing that quantized vortices act as both sources and probes of the unstable flow.

Conduction of neural impulses along axons in the brain is sped up by a substance called myelin, which changes during development and learning. This study reveals that myelin remodelling coordinates and optimizes neuronal communication.

Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing epithelial–stromal remodelling and suppression of luminal progenitors.

cellDancer enables RNA velocity estimation with cell-specific kinetics.

Measurements of an intense radio burst from a Galactic magnetar provide evidence that magnetars are the probable source of some fast radio bursts.

High numbers of COVID-19-related deaths have been reported in the United States, but estimation of the true numbers of infections is challenging. Here, the authors estimate that on 1 June 2020, 3.7% of the US population was infected with SARS-CoV-2, and 0.01% was infectious, with wide variation by state.

The Kondo effect from magnetic impurities has been proposed as a probe of fractionalized excitations in a topological quantum spin liquid. Lee et al. experimentally demonstrate the Kondo effect in a Kitaev candidate material α-RuCl3 with dilute Cr impurities.

Semiconductor nanoplatelets emit light in narrow spectral ranges. Here, the authors establish a theoretical model showing this behavior is controlled by the inhomogeneities of the ligand layer on the nanoplatelet surface.

Using multiple datasets from real-world evidence and completed trials, a machine learning model using routine blood and clinical data is shown to be predictive of patient response to immune checkpoint inhibitor therapy, across cancer types and outperforming standard biomarkers.

Disorder has been a prime challenge to study the topological properties in a hybrid system. Here, Zhanget al. report ballistic superconductivity in InSb nanowires interfacing with a NbTiN superconductor, paving the way for disorder-free Majorana devices.

Magic-angle twisted bilayer graphene exhibits a quantum anomalous Hall effect at 3/4 filling; however, its mechanism is debated. Here, the authors show that such a phase can be realized in a lattice model of twisted bilayer graphene in the strong coupling limit, and interpret the results in terms of a topological Mott insulator phase.

The response of the electronic structure to the non-trivial polarization texture in PbTiO₃/SrTiO₃ superlattices has not been explored. Here, the authors reveal how the peaks of the spectra shift and change their local electronic structure depending on the position of the Ti cation.

Here the authors present a method to transform polygenic scores into disorder probabilities using only GWAS summary statistics, genotype data and a prior - no tuning sample is needed. The method enables individualized, well-calibrated predictions.

Using data from 142,238 Mass General Brigham Biobank participants, researchers explored population history and social and genetic risk factors for disease in Greater Boston. The study links genetics and context to guide equitable precision health.

Ribosome loading is predictably controlled through design of 5′ UTR sequences.

A self-consistent model that bridges electrochemistry and solid-state physics is developed to fully describe the ion and electron distribution at solid electrode/electrolyte interfaces and applied to lower interfacial resistance in batteries.

The coherence of a close-to-ideal laser beam can be quadratically better than what was believed to be the quantum limit. This new Heisenberg limit could be attained with circuit quantum electrodynamics.

The authors study a liquid crystal microcavity with polarization-dependent absorption, a source of non-Hermiticity. The transition in the Hermitian topology of the spin-orbit coupling makes possible the annihilation of exceptional points.

Phenotypic variation and diseases are influenced by factors such as genetic variants and gene expression. Here, Barbeira et al. develop S-PrediXcan to compute PrediXcan results using summary data, and investigate the effects of gene expression variation on human phenotypes in 44 GTEx tissues and >100 phenotypes.

A macroscopic analogue of a spin system is shown to emerge in an ensemble of droplets bouncing on the surface of a vibrating bath, revealing symmetry-breaking phenomena such as ‘magnetic’ ordering.

Ice cores are unique climate archives, but their dating can be challenging. Here, the authors have realized a method for counting ⁸¹Kr atoms in 1-kg polar ice-core samples, enabling access to climate information of the past million years in deep ice.

Applying economic complexity methods, this study maps global progress toward the SDGs, uncovering distinct development paths and disparities among 166 countries. It highlights overlooked areas in sustainable development, offering insights into how nations can better achieve the SDGs.

Quantum entanglement contains important information about quantum systems, but its calculation is challenging. Here the authors develop a quantum Monte Carlo technique for full tomography on microscopic subregions of a system, enabling extraction of multipartite quantum entanglement in large scale models.

By integrating a ribo-seq dataset of 195 individuals with RNA-seq and proteomics data from the same cohort, researchers found prevalent post-transcriptional attenuation of eQTL effects and identified omic-specific QTLs associated with schizophrenia.

Despite the progression of Actinium-225 (225Ac) radiopharmaceuticals, there is still a limited understanding of Ac coordination chemistry due to its radioactivity, poor availability, and lack of stable isotopes. Here, the authors demonstrate a platform to characterize the solution and solid-state behavior of the longest-lived Ac isotope, 227Ac.

The understanding of charge density wave (CDW) correlations in cuprate superconductors remains hampered due to the lack of scattering phase information. Here, Chen et al. discover a reproducible CDW domain memory effect upon repeated cycling to temperatures well above the CDW ordering temperature.

Quantum spin-ice phases are predicted to have emergent gauge fields and fractionalization. Neutron scattering and thermodynamic measurements of the quantum spin-ice candidate Ce₂Zr₂O₇ show features consistent with these predictions.

TbMn6Sn6 exhibits a spin-reorientation transition above 310K, which could allow for switching of topological magnetic properties. Here, Riberolles et al use inelastic neutron scattering techniques to study this spin reorientation transition showing that it is driven by the orbital dynamics of the Tb ions, which can be described by a quantum two-state orbital model. On short timescales, the material behaves as a classical magnetic binary alloy, while on longer timescales, this averages out to a homogenous system with some average anisotropy.

In this work, authors tracked a pneumococcal serotype 3 strain persisting for a year in a healthy adult, revealing limited genetic change but stable multidrug resistance and features linked to vaccine escape.

The SARS-CoV-2 virus has altered people’s lives around the world, not only through the disease it causes, but also through unprecedented restrictions. Here the authors document population-wide shifts in dietary interests in 18 countries in 2020, as revealed through time series of Google search volumes.

Changes in protein subcellular localization can be determined using mass spectrometry. Here, the authors present a statistical approach to determine relocalising proteins from spatial proteomics experiments.

Here, the authors investigate chromatin-based gene regulation in the closest relative of animal, choanoflagellates. They uncover a putative dual role for the histone modification H3K27me3 in regulating of protein-coding genes during differentiation and transposable elements.

A distribution in fin widths, due to variability in the fabrication process, can be used to study a latching condition in gallium nitride transistors in which drain current sharply transits from an off-state value to a high on-state value with a slope of less than 60 mV per decade.

Microhomology-mediated end joining (MMEJ) and mitotic DNA synthesis (MiDAS) are critical DNA repair pathways in mitosis. Here the authors show that CIP2A–TOPBP1 coordinate mitotic DNA repair through the regulation of factors required for MiDAS and MMEJ.

Production of bulk bicontinuous materials is limited by the ability to make uniform microarchitectures across large volumes. Here elastic microphase separation is used to fabricate bicontinuous materials with a homogeneous microstructure, with feature sizes tuned by the matrix stiffness.

The bacterial genotoxin colibactin induces DNA interstrand cross-links which pose a barrier to DNA replication. Here, the authors use Xenopus egg extracts to show that the Fanconi anemia pathway is responsible for repairing these cross-links.