Nature Search

Passage of the Sperm and the Penetration of the Egg in Mammals

C. R. AUSTIN
A. W. H. BRADEN
Research29 Nov 1952
Nature

Volume: 170, P: 919-921
Compositional Implications of the Spectral Behaviour of the Martian Surface

J. W. SALISBURY
G. R. HUNT
Research12 Apr 1969
Nature

Volume: 222, P: 132-136
3-Oxothiolase Activities and [¹⁴C]-2-Methylbutanoic Acid Incorporation in Cultured Fibroblasts from 13 Cases of Suspected 3-Oxothiolase Deficiency

Pål Iden
Bruce Middleton
Oddmund Søvik
Research01 Nov 1990
Pediatric Research

Volume: 28, P: 518-522
Africa-specific human genetic variation near CHD1L associates with HIV-1 load

Africa-specific genetic variation on chromosome 1 near CHD1L is associated with HIV replication in vivo.

Paul J. McLaren
Immacolata Porreca
Jacques Fellay
Research02 Aug 2023
Nature

Volume: 620, P: 1025-1030
Precipitin Reactions in Forensic Problems: A New Method for Precipitin Reactions on Forensic Blood, Semen and Saliva Stains

BRYAN J. CULLIFORD
Research14 Mar 1964
Nature

Volume: 201, P: 1092-1093
Discovery and biosynthesis of cyclic plant peptides via autocatalytic cyclases

BURP domains within lyciumin precursor peptides serve as autocatalytic peptide cyclases, enabling the discovery of other BURP-domain-derived products and development of a bioinformatic method to mine plants for precursor-peptide-encoding genes.

Desnor N. Chigumba
Lisa S. Mydy
Roland D. Kersten
Research22 Nov 2021
Nature Chemical Biology

Volume: 18, P: 18-28
In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice

In a mouse model of progeria, an adenine base editor delivered with adeno-associated virus corrects the pathogenic mutation in LMNA, rescues vascular pathology and markedly extends the lifespan of the mice.

Luke W. Koblan
Michael R. Erdos
David R. Liu
Research06 Jan 2021
Nature

Volume: 589, P: 608-614
An αvβ3 integrin checkpoint is critical for efficient T_H2 cell cytokine polarization and potentiation of antigen-specific immunity

Gata3 upregulation is required for T_H2 cell polarization. McKenzie and colleagues find that integrin αvβ3 is upregulated by Gata3 and that this is crucial in inducing FAK–mTOR signaling required for T_H2 cell differentiation.

Aydan C. H. Szeto
Ana C. F. Ferreira
Andrew N. J. McKenzie
Research22 Dec 2022
Nature Immunology

Volume: 24, P: 123-135
Structure and Function of the Sarcolemma of Skeletal Muscle

R. REED
T. W. HOUSTON
P. M. TODD
Research30 Jul 1966
Nature

Volume: 211, P: 534-536
Tertiary Mammalian Faunas and Sediments in Karamoja and Kavirondo, East Africa

W. W. BISHOP
F. WHYTE
Research29 Dec 1962
Nature

Volume: 196, P: 1283-1287
Climatic changes, Norsemen and modern man

W. Dansgaard
S. J. Johnsen
C. U. Hammer
Research01 May 1975
Nature

Volume: 255, P: 24-28
Carbon Fibres of High Strength and High Breaking Strain

R. MORETON
W. WATT
W. JOHNSON
Research18 Feb 1967
Nature

Volume: 213, P: 690-691
Nitrogenase activity in rhizobia in absence of plant host

W. G. W. KURZ
T. A. LARUE
Research31 Jul 1975
Nature

Volume: 256, P: 407-409
A Computer Programme for the Analysis of Human Chromosomes

C. W. GILBERT
Research24 Dec 1966
Nature

Volume: 212, P: 1437-1440
Oxidations and Transhydrogenations Involving Pyridine-Dinucleotides Catalysed by Bovine Milk Xanthine Oxidase

D. A. GILBERT
Research16 Mar 1963
Nature

Volume: 197, P: 1066-1068
The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells

The authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55α hyperactivation. They identify B55α and Greatwall levels as biomarkers of responses to Greatwall-targeted therapy.

Róbert Zach
Michael Annis
Helfrid Hochegger
ResearchOpen Access27 Aug 2025
Nature Communications

Volume: 16, P: 1-20
Motion cues provide the bee's visual world with a third dimension

M. Lehrer
M. V. Srinivasan
G. A. Horridge
Research24 Mar 1988
Nature

Volume: 332, P: 356-357
Adenine base editing in an adult mouse model of tyrosinaemia

Intravenous delivery of an adenine base editor and a single-guide RNA for the Fah gene can correct an A>G splice-site mutation in an adult mouse model of tyrosinaemia.

Chun-Qing Song
Tingting Jiang
Wen Xue
Research25 Feb 2019
Nature Biomedical Engineering

Volume: 4, P: 125-130
TDP-43 skein-like inclusions are formed by BAG3- and HSP70-guided co-aggregation with actin-binding proteins

Lu et al. show that, under proteotoxic stress, TDP-43 inclusions of skein-like morphology are guided by the chaperone HSP70 and its nucleotide exchange factor BAG3 to induce TDP-43 co-aggregation with F-actin-bound actin-binding proteins.

Shan Lu
Sitao Zhang
Don W. Cleveland
Research31 Oct 2025
Nature Cell Biology

Volume: 27, P: 1925-1937
Large transient assemblies of Apaf1 constitute the apoptosome in cells

The apoptosome is known as a protein complex that initiates cell death. Here Borgeaud et al. reveal that in living cells, the apoptosome protein components assemble into dynamic meshwork-like structures that dissociate in cells surviving apoptosis.

Alicia C. Borgeaud
Iva Ganeva
Wanda Kukulski
ResearchOpen Access24 Oct 2025
Nature Communications

Volume: 16, P: 1-12
Clinically relevant antibiotic resistance genes are linked to a limited set of taxa within gut microbiome worldwide

Antimicrobial resistance genes (ARGs) in commensal gut bacteria may act as a reservoir for acquisition by pathogens. Here, the authors assess the distribution and transfer potential of ARGs in gut microbiomes and find that clinically important ARGs are taxonomically restricted despite being associated with mobile plasmids

Peter J. Diebold
Matthew W. Rhee
Ilana L. Brito
ResearchOpen Access14 Nov 2023
Nature Communications

Volume: 14, P: 1-12
Study of Anticholinesterase Action in Insects by a Labelled Pool Technique

F. P. W. WINTERINGHAM
A. HARRISON
Research14 Jul 1956
Nature

Volume: 178, P: 81-83
Precise kilobase-scale genomic insertions in mammalian cells using PASTE

Programmable addition via site-specific targeting elements (PASTE) combines the specificity, efficiency and cargo size benefits of site-specific integrases with the programmability of prime editing for precise and efficient integration of large DNA sequences into mammalian genomes.

Christopher W. Fell
Cian Schmitt-Ulms
Omar O. Abudayyeh
Protocols15 Dec 2024
Nature Protocols

Volume: 20, P: 1546-1583
Host–microbe interactions rewire metabolism in a C. elegans model of leucine breakdown deficiency

In a C. elegans model of defective leucine catabolism, Lee et al. analyse how the complex interplay between host and bacteria rewires metabolism to enable host survival.

Yong-Uk Lee
Bennett W. Fox
Albertha J. M. Walhout
Research08 Aug 2024
Nature Metabolism

Volume: 6, P: 1584-1600
Stabilized Interference Fringes on the Retina

R. W. DITCHBURN
R. M. PRITCHARD
Research03 Mar 1956
Nature

Volume: 177, P: 434
Enzymatic combinatorial synthesis of E-64 and related cysteine protease inhibitors

Liu et al. discover amide-forming enzymes in the biosynthesis of E-64, a classic cysteine protease inhibitor. Enzymatic combinatorial biocatalysis creates a large compound library and leads to the identification of useful cathepsin inhibitors.

Mengting Liu
Xin Zang
Yi Tang
ResearchOpen Access09 May 2025
Nature Chemical Biology

Volume: 21, P: 1783-1793
Cyclodipeptide oxidase is an enzyme filament

Many cyclic dipeptide natural products can be modified by cyclodipeptide oxidase enzymes. Here, the authors report the structural characterization of the cyclodipeptide oxidase AlbAB and show that it assembles into heterooligomeric enzyme filaments.

Michael P. Andreas
Tobias W. Giessen
ResearchOpen Access27 Apr 2024
Nature Communications

Volume: 15, P: 1-14
Glutamate indicators with improved activation kinetics and localization for imaging synaptic transmission

iGluSnFR variants with improved signal-to-noise ratios and targeting to postsynaptic sites have been developed, enabling the analysis of glutamatergic neurotransmission in vivo as illustrated in the mouse visual and somatosensory cortex.

Abhi Aggarwal
Rui Liu
Kaspar Podgorski
ResearchOpen Access04 May 2023
Nature Methods

Volume: 20, P: 925-934
Thymol Basic Ethers and Related Compounds: Central Nervous System Depressant Action

A. ASHFORD
C. J. SHARPE
F. F. STEPHENS
Research09 Mar 1963
Nature

Volume: 197, P: 969-971
Identification of medication–microbiome interactions that affect gut infection

An analysis of prescription medications shows that several non-antibiotic drugs, such as the heart medication digoxin, can reduce the immune response to pathogens and increase the risk of gastrointestinal infections by altering the composition of the microbiome.

Aman Kumar
Ruizheng Sun
Andrew L. Goodman
Research16 Jul 2025
Nature

Volume: 644, P: 506-515
Thysanoessa inermis and T. longicaudata (Euphausiidae) as First Intermediate Hosts of Anisakis sp. (Nematoda: Ascaridata) in the Northern North Sea, to the North of Scotland and at Faroe

JOHN W. SMITH
Research24 Dec 1971
Nature

Volume: 234, P: 478
A multiprotein supercomplex controlling oncogenic signalling in lymphoma

A pro-survival multiprotein signalling supercomplex consisting of the B cell receptor, MYD88, TLR9 and mTOR is discovered that coordinates NF-κB activation in diffuse large B cell lymphoma, and provides mechanistic insight into the efficacy of drug combinations.

James D. Phelan
Ryan M. Young
Louis M. Staudt
Research20 Jun 2018
Nature

Volume: 560, P: 387-391
Cyclophosphamide: Induction of Superovulation in Rats

W. R. RUSSELL
A. L. WALPOLE
A. P. LABHSETWAR
Research12 Jan 1973
Nature

Volume: 241, P: 129-130
Tumor Necrosis Factor-Induced Neonatal Pulmonary Hypertension: Effects of Dazmegrel Pretreatment

W E Truog
R L Gibson Jr.
G J Redding
Research01 May 1990
Pediatric Research

Volume: 27, P: 466-471
¹³C Nuclear Magnetic Resonance Spectrum of Gramicidin S-A, a Decapeptide Antibiotic

W. A. GIBBONS
J. A. SOGN
L. F. JOHNSON
Research22 Aug 1970
Nature

Volume: 227, P: 840-842
Growth of complete ammonia oxidizers on guanidine

Nitrospira inopinata and probably most other comammox microorganisms can grow on the non-conventional substrate guanidine as the sole source of energy, reductant and nitrogen.

Marton Palatinszky
Craig W. Herbold
Michael Wagner
ResearchOpen Access14 Aug 2024
Nature

Volume: 633, P: 646-653
CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

Alterations in the tumour suppressor genes STK11 and/or KEAP1 can identify patients with advanced non-small-cell lung cancer who are likely to benefit from combinations of PD-(L)1 and CTLA4 immune checkpoint inhibitors added to chemotherapy.

Ferdinandos Skoulidis
Haniel A. Araujo
John V. Heymach
ResearchOpen Access09 Oct 2024
Nature

Volume: 635, P: 462-471
Isogenic Group B Streptococci Devoid of Capsular Polysaccharide or β-Hemolysin: Pulmonary Hemodynamic and Gas Exchange Effects during Bacteremia in Piglets

R L Gibson
G J Redding
C E Rubens
Research01 Sept 1989
Pediatric Research

Volume: 26, P: 241-245
Central control of dynamic gene circuits governs T cell rest and activation

Resting and activated T cell states are established by context-specific regulators and dynamic gene circuits.

Maya M. Arce
Jennifer M. Umhoefer
Alexander Marson
ResearchOpen Access11 Dec 2024
Nature

Volume: 637, P: 930-939
Relationship Between Oxidation of Isocitrate and Metabolism of Fatty Acids in Rabbit-Heart Sarcosomes

W. C. HÜLSMANN
Research23 Dec 1961
Nature

Volume: 192, P: 1153-1155
Engineered yeast genomes accurately assembled from pure and mixed samples

The cost and complexity of whole genome sequencing limits its use in identifying and validating sequences used for genetic engineering and synthetic biology. Here the authors present Prymetime, an integrated workflow to sequence engineered strains and identify engineering in metagenomes.

Joseph H. Collins
Kevin W. Keating
Eric M. Young
ResearchOpen Access05 Mar 2021
Nature Communications

Volume: 12, P: 1-15
Structural rearrangements allow nucleic acid discrimination by type I-D Cascade

I-D CRISPR-Cascade can target both single-stranded and double-stranded nucleic acids. Here, Schwartz et. al determine these structures and reveal large-scale rearrangements that allow for target discrimination and destruction.

Evan A. Schwartz
Tess M. McBride
David W. Taylor
ResearchOpen Access20 May 2022
Nature Communications

Volume: 13, P: 1-11
Frequent transitions in self-assembly across the evolution of a central metabolic enzyme

Many enzymes form homo-oligomers, but it is often not clear why. This study follows the evolution self-assembly in citrate synthases across their phylogeny and finds it to be variable and not obviously related to enzyme function.

Franziska L. Sendker
Tabea Schlotthauer
Georg K. A. Hochberg
ResearchOpen Access03 Dec 2024
Nature Communications

Volume: 15, P: 1-13
Bladder cancer variants share aggressive features including a CA125+ cell state and targetable TM4SF1 expression

Single cell analysis of histologic variant bladder tumors detects a shared CA125+ tumor cell state associated with aggressive clinical features and reveals enriched expression of TM4SF1, a membrane protein that can be targeted with CAR T cells.

Heiko Yang
Hanbing Song
Franklin W. Huang
ResearchOpen Access17 Jun 2025
Nature Communications

Volume: 16, P: 1-12
Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension

TRPV4 dominant mutations cause neuropathy. Here, the authors show that TRPV4 binds and interacts with RhoA, modulating the actin cytoskeleton. Neuropathy-causing mutations of TRPV4 disrupt this complex, leading to RhoA activation and impairment of neurite extension in cultured cells and flies.

Brett A. McCray
Erika Diehl
Charlotte J. Sumner
ResearchOpen Access04 Mar 2021
Nature Communications

Volume: 12, P: 1-17
CRAGE enables rapid activation of biosynthetic gene clusters in undomesticated bacteria

Chassis-independent recombinase-assisted genome engineering (CRAGE) enables the integration of plasmids encoding biosynthetic gene clusters into the chromosomes of diverse bacteria to optimize production of natural products in non-native strains.

Gaoyan Wang
Zhiying Zhao
Yasuo Yoshikuni
Research14 Oct 2019
Nature Microbiology

Volume: 4, P: 2498-2510
CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research

During each replication cycle of P. falciparum in the human bloodstream, a small proportion of parasites commits to sexual development and differentiates into transmission-relevant gametocytes. Applying CRISPR-based genome editing, Boltryk et al. engineer P. falciparum lines with sexual commitment rates of 75% to promote future studies on gametocyte biology.

Sylwia D. Boltryk
Armin Passecker
Till S. Voss
ResearchOpen Access10 Aug 2021
Nature Communications

Volume: 12, P: 1-16
An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism

The use of synthetic organisms could provide opportunities for discovery and advanced manufacturing of medical drugs. Here the authors use a semi-synthetic organism with an expanded genetic code to generate site-specific chemical modifications in human IL-2.

Jerod L. Ptacin
Carolina E. Caffaro
Marcos E. Milla
ResearchOpen Access09 Aug 2021
Nature Communications

Volume: 12, P: 1-14
Atmospheric Sodium measured by a Tuned Laser Radar

M. R. BOWMAN
A. J. GIBSON
M. C. W. SANDFORD
Research01 Feb 1969
Nature

Volume: 221, P: 456-457
Studies in Acute Iron Poisoning III. The Hemodynamic Alterations in Acute Experimental Iron Poisoning

C F Whitten
Y C Chen
G W Gibson
Research01 Nov 1968
Pediatric Research

Volume: 2, P: 479-485

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