Schematic illustration showing our overall approach, studies performed, and envisioned application. Our strategy combines biomechanical and biochemical cues from a mechanically graded biomaterial and GF biopatterning, respectively, to spatially control bone- and tendon-like differentiation. Here, experiments (i) characterized our biomaterial, (ii) investigated the interplay between biomechanical and biochemical cues in vitro, and (iii) assessed the ability of our GF-biopatterned and biphasic biomaterial to spatially control bone- and tendon-like tissue formation in vivo. The envisioned goal of this study is to develop a biomaterial for treating large-to-massive tendon injuries.
- Dan Wang
- Dai Fei Elmer Ker
- Yunzhi Peter Yang
