Cones generate a finely graded voltage signal over a range of light intensities that must be translated into quantal neurotransmitter release at the synapse. Here the authors track synaptic vesicle dynamics in darkness and in light, suggesting that vesicle depletion and resupply mediate the dynamic range of cone synapses.
- Skyler L Jackman
- Sue-Yeon Choi
- Richard H Kramer