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Viruses such as EBV use various mechanisms to avoid antiviral responses. Here the authors propose that the EBV protein BRRF2 is secreted via extracellular vesicles from NPC cells, disrupts the cGAS-STING pathway, reduces cGAS-DNA phase separation and the subsequent antiviral response.

Spiral spin liquids emerge from cooperative fluctuations among degenerate spiral states. Here, Zhao et al uncover itinerant and topological low-energy spin excitations intrinsic to the spiral spin-liquid candidate material GdZnPO.

Two-qubit operations exceeding 99% fidelity have been demonstrated by silicon devices made with standard semiconductor tooling in a 300-mm foundry environment.

Myasthenia gravis (MG) is an autoimmune condition leading to extreme muscle weakness due to autoantibodies targeting the neuromuscular junctions. Here authors assign a critical role for platelets in amplifying the pro-inflammatory response in AChR+ immunotherapy-naïve MG (nMG) patients and thus contributing to disease pathology.

The function and regulatory mechanism of mRNA acetylation modification in cancer progression remains largely unknown. Here the authors identify that targeting tumor N4-acetylcytidine (ac4C) RNA acetyltransferase NAT10 improves anti-tumor response via MYC/CDK2/DNMT1/dsRNA/type I IFN pathway, and show the synergic anti-tumor effect of NAT10 inhibition with aPD-1.

The gut microbiota bacterium Ruminococcus gnavus is implicated in the development of cirrhotic liver encephalopathy through the production of neurotoxins.

An electrostatic-repulsion-enabled advanced transfer technique based on ammonia solution is introduced for separating van der Waals thin-film materials from their substrates, demonstrating suitability for its use in the complementary metal–oxide–semiconductor (CMOS) industry.

In a small trial of patients with severe systemic lupus erythematosus and nephritis, treatment with allogeneic T cells with a CD19 chimeric antigen receptor inserted into the T cell receptor locus and deletion of the PD-1 (PDCD1) gene were safe and associated with reduced disease activity.

The nature of the dominant pairing mechanism in some two-dimensional transition metal dichalcogenides is still debated. Here, the authors predict that the Kohn-Luttinger mechanism induces chiral p-wave superconductivity in monolayer NbSe₂.

Liver proteome dysregulation contributes to the development of alcohol-associated liver disease (ALD), a major global health challenge. Here, the authors develop an approach to specifically identify the liver nascent proteome under various physiological and pathological conditions, revealing key regulators involved in hepatic steatosis.

Metal-tip-based electron sources are constrained by a trade-off between energy spread and pulse width. Here the authors report a carbon-nanotube-based electron source with a 0.3-eV energy spread and an electron pulse width of about 13 fs.

A new type of Fe/N–C catalyst composed of numerous nanoprotrusions dispersed on two-dimensional carbon layers with inner-embedded single Fe-atom sites has been developed that delivers a high-performance platinum group metal-free proton-exchange membrane fuel cell.

Hair cell loss is a major cause of deafness. Here the authors reveal that enhancing Jagged1-Notch signaling in supporting cells boosts their ability to form hair cells in pre-hearing mice, identifying Jagged1 as a target for future restoration therapies.

Most superconductors that exhibit exotic pairing symmetries are derived from host materials that are Mott insulators. Xiangang Wan and Sergey Savrasov show that it may be possible to realize an exotic p-wave superconductor in doped Bi₂Se₃, which is a topological band insulator.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

Alkaline hydrogen production needs stable catalysts, but the electrical double layer is overlooked. Here, the authors report a dense epitaxial hydroxide layer that strengthens the double layer, prevents catalyst leaching, and enhances material stability for 1,400 h in an industrial electrolyzer.

Rapid diagnosis of bloodstream infections is vital for timely effective treatment. Here, Mao and Wan et al developed a method using a dual stem-loop DNA signal amplifier, to achieve ultrasensitive, rapid, amplification-free detection of pathogens from human serum.

This work presents MAPIT-seq, an antibody-guided RNA editing method that enables co-profiling of RBP-RNA interactions and gene expression at single-cell resolution and in tissue contexts.

Yuan et al. report a nearly vertical subthreshold swing field-effect transistor consists of a graphene/silicon heterojunction drain and a silicon channel. The device enables nearly hysteresis-free transistors with subthreshold swing of 16 µV dec⁻¹, and a complementary logic inverter with gain of 311.

Temporal variability of structural-functional coupling (SFC) remains poorly understood. Here, authors show such variability is underpinned by specific transcriptomic and chemoarchitectural signatures, thereby supporting neurocognitive specialization.

The formation of 2D perovskites in inorganic perovskite solar cells is hindered by the strong binding affinity of caesium ions. Liu et al. engineer the functional groups of a large organic cation to facilitate its exchange with caesium ions and form a stable 2D perovskite.

EviDTI introduces an evidential deep learning framework for drug-target interaction prediction, providing reliable uncertainty estimates to prioritize high-confidence predictions. It identifies potential tyrosine kinase modulators, thereby improving the efficiency of drug discovery.

Cu₂O is a promising photocatalyst, although its stability is compromised by a disproportionation reaction that leads to the formation of Cu and CuO. Now, a method is reported to stabilize Cu₂O nanocubes, rendering them highly active and stable for the photocatalytic reverse water–gas shift reaction.

This study reveals that α-lipoic acid (ALA) is reduced in aged mouse and human intestine and ALA supplementation reduces aging hallmarks. Paneth cells play a role in the effects of ALA.

Superconductivity has been induced in 2D electron gases, but high-field interplay between it and quantum Hall edge states remains elusive. Here the authors reach this regime by growing transparent superconducting contacts in GaAs, reporting modification of resistance in the quantum Hall regime.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Photonic memristor arrays fabricated from hexagonal boron nitride/silicon heterostructures provide a scalable, silicon-compatible solution for artificial vision systems, featuring broad spectral reconfigurability and promising performance characteristics.

Steam treatment transforms inactive Pd₁/CeO₂ catalyst into a highly reactive one by forming a Ce₂O₃-Pd nanoparticle interface. This domain interface is created by the coordinated migration of Ce and Pd atoms on the atom trapped Pd₁/CeO₂.

Cervical screening is a key method for detecting cervical cancer, but is limited by pathologist detection. Here, the authors use artificial intelligence to predict cytology grades from whole slide images.

Fur farming represents an important hub of cross-species transmission for viral zoonoses.

Methods for deuterium labelling of C–H bonds under mild conditions are sought after. Now an electrocatalytic method for H/D exchange via a radical-mediated pathway is described, using a boron cluster as a radical shuttle during the coupling process of deuterium and carbon radicals.

Partial oxidation of methane to value-added C₁ products remains challenging due to the favorable formation of fully-oxidized CO₂. Here, the authors show supported B₂O₃ catalysts with tri-coordinated BO₃ units as the active site are highly selective in oxidizing methane to HCHO and CO.

RNA modifications like m6A are vital for gene expression but challenging to detect at single-base resolution. Here, the authors introduce pum6a, an advanced computational framework, to enable precise single-base m6A detection and uncovering regulatory mechanisms in hypoxic cancer cells.

Superconductivity mediated by phonons is usually conventional due to isotropic electron-phonon coupling. Here, Wang et al. report highly anisotropic phonons only along [001] direction in Sr_0.1Bi₂Se₃, indicating a singular electron-phonon coupling which favors a p-wave nematic superconductivity scenario.

Magic state distillation is achieved with logical qubits on a neutral-atom quantum computer using a dynamically reconfigurable architecture for parallel quantum operations.

The dissatisfied delivery efficiency of drugs to lungs and other metastatic sites limit the corresponding therapeutic efficacy. Here this group reports an inhalable surfactant-based nanoliposome system to co-deliver Osimertinib and DNA plasmid which is capable of fusing into pulmonary surfactant, penetrating through physiological barriers and targeted accumulating in lung tissues.

Nickelate superconductors attract enormous attention in the field of high-temperature superconductivity. Here the authors report observation of perfect diamagnetism and interfacial effect on the electronic structures in infinite layer Nd_0.8Sr_0.2NiO₂ superconductors.

Polymer dielectrics have potential in capacitive energy storage applications, but achieving the required thermal stability and electrical insultation is challenging. Here, the authors report a method to rearrange short-range structural units within polyimide chains to give improved properties.

Plastic photoreforming offers a promising route for recycling plastic waste but typically depends on unsustainable, corrosive conditions. Here, the authors present a floatable organic–inorganic hybrid TiO₂ material that enables efficient conversion of common plastics such as PE, PP, and PVC under neutral conditions.

C(sp³)-C(sp³) amination represents a promising approach for synthesizing various amines, facilitating applications from late-stage scaffold hopping to the degradation of polymers and biomass. Herein, the authors report an electro-oxidative benzylic C(sp³)-C(sp³) amination reaction of aromatic hydrocarbons using nitriles, amides, and sulfonamides as nucleophiles.

Multi-species acute systemic toxicity assessment is fundamental for chemical classification, labelling and risk management. Here, the authors propose a machine learning paradigm, Adjoint Correlation Learning, yielding significant improvements for data-scarce endpoints and offering a useful computational tool for regulatory applications.