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Advanced filters: Author: Wataru Akahata Clear advanced filters

  • Chikungunya virus (CHIKV) is an emerging infectious agent that can cause severe disease in humans and against which there is presently no vaccine. Akahata et al. now describe their development of a virus-like particle (VLP) vaccine that elicits neutralizing antibodies against CHIKV and can protect nonhuman primates from infection. Their VLP-based approach may facilitate development of a CHIKV vaccine for human use.

    • Wataru Akahata
    • Zhi-Yong Yang
    • Gary J Nabel
    Research
    Nature Medicine
    Volume: 16, P: 334-338

  • Vaccines with broad and long-lasting protection against variants of concern are still limited. Here, the authors report a self-amplifying RNA (saRNA) vaccine expressing a membrane-anchored SARS-CoV-2 Spike RBD and show that it elicits broad, durable and protective immunity in small animal models and NHPs.

    • Mai Komori
    • Takuto Nogimori
    • Wataru Akahata
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14