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Neuropsychopharmacology (17)
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Showing 1–50 of 57 results

Advanced filters: Author: Wayne Drevets Clear advanced filters

Neurocircuitry of Mood Disorders

Joseph L Price
Wayne C Drevets
Reviews19 Aug 2009
Neuropsychopharmacology

Volume: 35, P: 192-216
Subgenual prefrontal cortex abnormalities in mood disorders

Wayne C. Drevets
Joseph L. Price
Marcus E. Raichle
Research24 Apr 1997
Nature

Volume: 386, P: 824-827
Publisher Correction: ASPI: a public–private partnership to develop treatments for autism

Seth Ness
Gahan Pandina
Husseini K. Manji
Amendments and Corrections06 May 2020
Nature Reviews Drug Discovery

Volume: 19, P: 427
Blood flow changes in human somatosensory cortex during anticipated stimulation

Wayne C. Drevets
Harold Burton
Marcus E. Raichle
Research19 Jan 1995
Nature

Volume: 373, P: 249-252
Discovering Endophenotypes for Major Depression

Gregor Hasler
Wayne C Drevets
Dennis S Charney
Reviews23 Jun 2004
Neuropsychopharmacology

Volume: 29, P: 1765-1781
The Effect of Acute Tryptophan Depletion on the Neural Correlates of Emotional Processing in Healthy Volunteers

Jonathan P Roiser
Jamey Levy
Wayne C Drevets
Research19 Sept 2007
Neuropsychopharmacology

Volume: 33, P: 1992-2006
Dopamine Type-1 Receptor Binding in Major Depressive Disorder Assessed Using Positron Emission Tomography and [¹¹C]NNC-112

Dara M Cannon
Jacqueline M Klaver
Wayne C Drevets
Research22 Oct 2008
Neuropsychopharmacology

Volume: 34, P: 1277-1287
Effects of a α_2C-Adrenoreceptor Gene Polymorphism on Neural Responses to Facial Expressions in Depression

Alexander Neumeister
Wayne C Drevets
Dennis S Charney
Research11 Jan 2006
Neuropsychopharmacology

Volume: 31, P: 1750-1756
Scopolamine Produces Larger Antidepressant and Antianxiety Effects in Women Than in Men

Maura L Furey
Ashish Khanna
Wayne C Drevets
Research25 Aug 2010
Neuropsychopharmacology

Volume: 35, P: 2479-2488
Postpartum and Depression Status are Associated With Lower [¹¹C]raclopride BP_ND in Reproductive-Age Women

Eydie L Moses-Kolko
Julie C Price
Wayne C Drevets
Research18 Jan 2012
Neuropsychopharmacology

Volume: 37, P: 1422-1432
Putative Neuroprotective and Neurotoxic Kynurenine Pathway Metabolites Are Associated with Hippocampal and Amygdalar Volumes in Subjects with Major Depressive Disorder

Jonathan Savitz
Wayne C Drevets
Robert Dantzer
Research30 Jul 2014
Neuropsychopharmacology

Volume: 40, P: 463-471
Whole-blood expression of inflammasome- and glucocorticoid-related mRNAs correctly separates treatment-resistant depressed patients from drug-free and responsive patients in the BIODEP study

Annamaria Cattaneo
Clarissa Ferrari
Carmine M. Pariante
ResearchOpen Access23 Jul 2020
Translational Psychiatry

Volume: 10, P: 1-14
Neuroplasticity and cellular resilience in mood disorders

H K Manji
G J Moore
G Chen
Research17 Nov 2000
Molecular Psychiatry

Volume: 5, P: 578-593
Immune targets for therapeutic development in depression: towards precision medicine

Accumulating evidence suggests that, for some people, major depressive disorder has immunological roots. Here, Manji and colleagues discuss the progress towards immune-based treatments for depression, including which biomarkers might be most useful, as well as potential challenges to this approach.

Wayne C. Drevets
Gayle M. Wittenberg
Husseini K. Manji
Reviews17 Jan 2022
Nature Reviews Drug Discovery

Volume: 21, P: 224-244
The cellular neurobiology of depression

Husseini K. Manji
Wayne C. Drevets
Dennis S. Charney
Reviews01 May 2001
Nature Medicine

Volume: 7, P: 541-547
ASPI: a public–private partnership to develop treatments for autism

Numerous potential therapeutic targets are being investigated in autism spectrum disorder (ASD). Here, we discuss a platform trial approach for designing proof-of-concept (POC) clinical studies of ASD — via the Autism Spectrum POC Initiative (ASPI) — that can be conducted through a public–private partnership with the aim of finding effective treatments in the most expeditious manner.

Seth Ness
Gahan Pandina
Husseini K. Manji
Comments & Opinion22 Jan 2020
Nature Reviews Drug Discovery

Volume: 19, P: 219-220
Cerebrospinal Fluid Metabolome in Mood Disorders-Remission State has a Unique Metabolic Profile

Rima Kaddurah-Daouk
Peixiong Yuan
Wayne Drevets
ResearchOpen Access19 Sept 2012
Scientific Reports

Volume: 2, P: 1-10
Treatment of bipolar depression with minocycline and/or aspirin: an adaptive, 2×2 double-blind, randomized, placebo-controlled, phase IIA clinical trial

Jonathan B. Savitz
T. Kent Teague
Sheldon H. Preskorn
ResearchOpen Access24 Jan 2018
Translational Psychiatry

Volume: 8, P: 1-11
Novel genetic loci associated with hippocampal volume

The hippocampus in mammalian brain varies in size across individuals. Here, Hibar and colleagues perform a genome-wide association meta-analysis to find six genetic loci with significant association to hippocampus volume.

Derrek P. Hibar
Hieab H. H. Adams
M. Arfan Ikram
ResearchOpen Access18 Jan 2017
Nature Communications

Volume: 8, P: 1-12
Anterior Cingulate Desynchronization and Functional Connectivity with the Amygdala During a Working Memory Task Predict Rapid Antidepressant Response to Ketamine

Giacomo Salvadore
Brian R Cornwell
Carlos A Zarate Jr
Research10 Mar 2010
Neuropsychopharmacology

Volume: 35, P: 1415-1422
Novel genetic loci underlying human intracranial volume identified through genome-wide association

In a GWAS study of 32,438 adults, the authors discovered five novel loci for intracranial volume and confirmed two known signals. Variants for intracranial volume were also related to childhood and adult cognitive function and to Parkinson's disease, and enriched near genes involved in growth pathways, including PI3K-AKT signaling.

Hieab H H Adams
Derrek P Hibar
Paul M Thompson
Research03 Oct 2016
Nature Neuroscience

Volume: 19, P: 1569-1582
Effects of arterial cannulation stress on regional cerebral blood flow in major depressive disorder

Jonathan Savitz
Allison C. Nugent
Wayne C. Drevets
ResearchOpen Access08 Mar 2012
Scientific Reports

Volume: 2, P: 1-15
Efficacy and safety of aticaprant, a kappa receptor antagonist, adjunctive to oral SSRI/SNRI antidepressant in major depressive disorder: results of a phase 2 randomized, double-blind, placebo-controlled study

Mark E. Schmidt
Iva Kezic
Wayne C. Drevets
ResearchOpen Access22 Apr 2024
Neuropsychopharmacology

Volume: 49, P: 1437-1447
Impairments of Probabilistic Response Reversal and Passive Avoidance Following Catecholamine Depletion

Gregor Hasler
Krystal Mondillo
James R Blair
Research12 Aug 2009
Neuropsychopharmacology

Volume: 34, P: 2691-2698
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

Barbara Franke
Jason L Stein
Patrick F Sullivan
Research01 Feb 2016
Nature Neuroscience

Volume: 19, P: 420-431
Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans

Giacomo Salvadore
Pascal Bonaventure
Wayne C. Drevets
ResearchOpen Access07 Sept 2020
Translational Psychiatry

Volume: 10, P: 1-10
Striatal dopamine deficits predict reductions in striatal functional connectivity in major depression: a concurrent ¹¹C-raclopride positron emission tomography and functional magnetic resonance imaging investigation

J. Paul Hamilton
Matthew D. Sacchet
Ian H. Gotlib
ResearchOpen Access30 Nov 2018
Translational Psychiatry

Volume: 8, P: 1-10
Effects of immunomodulatory drugs on depressive symptoms: A mega-analysis of randomized, placebo-controlled clinical trials in inflammatory disorders

Gayle M. Wittenberg
Annie Stylianou
Wayne C. Drevets
ResearchOpen Access19 Aug 2019
Molecular Psychiatry

Volume: 25, P: 1275-1285
Altered cerebral benzodiazepine receptor binding in post-traumatic stress disorder

Inbal Reuveni
Allison C. Nugent
Omer Bonne
ResearchOpen Access04 Oct 2018
Translational Psychiatry

Volume: 8, P: 1-9
Common genetic variants influence human subcortical brain structures

Genome-wide association studies are used to identify common genetic variants that affect the structure of selected subcortical regions of the human brain; their identification provides insight into the causes of variability in brain development and may help to determine mechanisms of neuropsychiatric dysfunction.

Derrek P. Hibar
Jason L. Stein
Sarah E. Medland
Research21 Jan 2015
Nature

Volume: 520, P: 224-229
Identification of common variants associated with human hippocampal and intracranial volumes

Paul Thompson and colleagues report a genome-wide association study for hippocampal, intracranial and total brain volume. They identify a locus at 12q24 associated with hippocampal volume and a locus at 12q14 associated with intracranial volume.

Jason L Stein
Sarah E Medland
Paul M Thompson
Research15 Apr 2012
Nature Genetics

Volume: 44, P: 552-561
Individual Variations in Nucleus Accumbens Responses Associated with Major Depressive Disorder Symptoms

Masaya Misaki
Hideo Suzuki
Jerzy Bodurka
ResearchOpen Access16 Feb 2016
Scientific Reports

Volume: 6, P: 1-12
Treatment effect and safety of seltorexant as monotherapy for patients with major depressive disorder: a randomized, placebo-controlled clinical trial

Sofie Mesens
Iva Kezic
Wayne C. Drevets
ResearchOpen Access11 Dec 2024
Molecular Psychiatry

Volume: 30, P: 2427-2435
Efficacy and safety of JNJ-42165279, a fatty acid amide hydrolase inhibitor, in adolescents and adults with autism spectrum disorder: a randomized, phase 2, placebo-controlled study

Matthew E. Klein
Abigail Bangerter
Gahan Pandina
Research16 Oct 2024
Neuropsychopharmacology

Volume: 50, P: 480-487
No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageing

John J. Cole
Alison McColl
Jonathan Cavanagh
ResearchOpen Access22 Jul 2021
Translational Psychiatry

Volume: 11, P: 1-11
Genome-wide association study and polygenic risk score analysis of esketamine treatment response

Qingqin S. Li
Ewa Wajs
Wayne C. Drevets
ResearchOpen Access28 Jul 2020
Scientific Reports

Volume: 10, P: 1-9
Correction to: The selective orexin-2 antagonist seltorexant (JNJ-42847922/MIN-202) shows antidepressant and sleep-promoting effects in patients with major depressive disorder

Kasper Recourt
Peter de Boer
Wayne Drevets
Amendments and CorrectionsOpen Access02 Oct 2019
Translational Psychiatry

Volume: 9, P: 1
Correction: Exploratory genome-wide association analysis of response to ketamine and a polygenic analysis of response to scopolamine in depression

Wei Guo
Rodrigo Machado-Vieira
Yin Yao Shugart
Amendments and CorrectionsOpen Access05 Mar 2019
Translational Psychiatry

Volume: 9, P: 1
Personalized relapse prediction in patients with major depressive disorder using digital biomarkers

Srinivasan Vairavan
Homa Rashidisabet
Vaibhav A. Narayan
ResearchOpen Access30 Oct 2023
Scientific Reports

Volume: 13, P: 1-14
Higher immune-related gene expression in major depression is independent of CRP levels: results from the BIODEP study

Luca Sforzini
Annamaria Cattaneo
Carmine M. Pariante
ResearchOpen Access01 Jun 2023
Translational Psychiatry

Volume: 13, P: 1-13
Long-term safety and maintenance of response with esketamine nasal spray in participants with treatment-resistant depression: interim results of the SUSTAIN-3 study

Naim Zaki
Li (Nancy) Chen
Dong-Jing Fu
ResearchOpen Access12 May 2023
Neuropsychopharmacology

Volume: 48, P: 1225-1233
Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder

Kasper Recourt
Peter de Boer
Gabriel E. Jacobs
ResearchOpen Access24 Jul 2023
Translational Psychiatry

Volume: 13, P: 1-11
Meta-analysis of epigenome-wide association studies of major depressive disorder

Qingqin S. Li
Randall L. Morrison
Wayne C. Drevets
ResearchOpen Access01 Nov 2022
Scientific Reports

Volume: 12, P: 1-11
Genome-wide association study meta-analysis of suicide death and suicidal behavior

Qingqin S. Li
Andrey A. Shabalin
Hilary Coon
ResearchOpen Access17 Oct 2022
Molecular Psychiatry

Volume: 28, P: 891-900
The effects of inhibition of fatty acid amide hydrolase (FAAH) by JNJ-42165279 in social anxiety disorder: a double-blind, randomized, placebo-controlled proof-of-concept study

Mark E. Schmidt
Michael R. Liebowitz
Wayne C. Drevets
ResearchOpen Access18 Oct 2020
Neuropsychopharmacology

Volume: 46, P: 1004-1010
The selective orexin-2 antagonist seltorexant (JNJ-42847922/MIN-202) shows antidepressant and sleep-promoting effects in patients with major depressive disorder

Kasper Recourt
Peter de Boer
Wayne Drevets
ResearchOpen Access03 Sept 2019
Translational Psychiatry

Volume: 9, P: 1-10
Exploratory genome-wide association analysis of response to ketamine and a polygenic analysis of response to scopolamine in depression

Wei Guo
Rodrigo Machado-Vieira
Yin Yao Shugart
ResearchOpen Access14 Dec 2018
Translational Psychiatry

Volume: 8, P: 1-8
Identification and replication of RNA-Seq gene network modules associated with depression severity

Trang T. Le
Jonathan Savitz
Jerzy Bodurka
ResearchOpen Access05 Sept 2018
Translational Psychiatry

Volume: 8, P: 1-12
Appetite changes reveal depression subgroups with distinct endocrine, metabolic, and immune states

W. Kyle Simmons
Kaiping Burrows
Wayne C. Drevets
Research13 Jun 2018
Molecular Psychiatry

Volume: 25, P: 1457-1468
Repeated exposure to systemic inflammation and risk of new depressive symptoms among older adults

J A Bell
M Kivimäki
L A Carvalho
ResearchOpen Access15 Aug 2017
Translational Psychiatry

Volume: 7, P: e1208

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